---
title: "ADSP releases quality-controlled whole-genome data on nearly 17,000 samples"
id: "3209"
type: "post"
slug: "adsp-releases-quality-controlled-whole-genome-data-on-nearly-17000-samples"
published_at: "2021-10-29T16:52:35+00:00"
modified_at: "2022-12-21T20:20:51+00:00"
url: "https://dss.niagads.org/adsp-releases-quality-controlled-whole-genome-data-on-nearly-17000-samples/"
markdown_url: "https://dss.niagads.org/adsp-releases-quality-controlled-whole-genome-data-on-nearly-17000-samples.md"
excerpt: "NIAGADS is pleased to announce the release of the Release 3 (R3) WGS ADSP quality-controlled joint genotype called pVCF containing 16,905 samples. Additionally, this release includes a quality-controlled X-chromosome pseudoautosomal region (PAR) pVCF containing 20,503 whole exomes from Release 2..."
taxonomy_category:
  - "ADSP"
  - "GCAD"
---

NIAGADS is pleased to announce the release of the Release 3 (R3) WGS ADSP quality-controlled joint genotype called pVCF containing 16,905 samples. Additionally, this release includes a quality-controlled X-chromosome pseudoautosomal region (PAR) pVCF containing 20,503 whole exomes from Release 2 (R2) as well as R3 individual-level VCF structural variant (SV) calls from 3 callers. These data are available for request through the [NIAGADS Data Sharing Service (DSS)](https://dss.niagads.org/)

The Release 3 (R3) pVCF includes whole-genome data from 1,020 ADSP Family Discovery and Discovery Extension samples, 2,959 ADSP Case Control Extension samples, 809 ADNI-WGS-1 samples, 886 CurePSP and Tau Consortium PSP samples, 408 PSP UCLA samples, 617 NINDS, CurePSP and Tau Consortium PSP samples, 209 University of Pittsburgh- Kamboh samples, 207 Cache County samples, 77 Knight ADRC samples, 91 FASe_families samples, 137 NACC-Genentech samples, 730 AMP-AD ROSMAP samples, 344 AMP-AD MSSM samples, 252 AMP-AD MAYO samples, and 8,160 ADSP Follow-Up Study 1 samples (FUS1 contains 885 ADSP FUS1 APOE Extremes samples, 2,771 ADSP FUS1 ADC Autopsy samples, 1,517 ADSP FUS1 PR1066 samples, 1,923 ADSP FUS1 ADGCAA samples, 757 ADSP FUS1 ADNI-WGS-2 samples, 92 ADSP FUS1 Miami HIHG Brain Bank samples, and 214 ADSP FUS1 StEP-AD samples).

These data were called by the Genome Center for Alzheimer’s Disease (GCAD) using VCPA 1.1, a functionally equivalent CCDG/TOPMed pipeline and subsequently run through the ADSP Quality Control pipeline. More information about the dataset can be found on the dataset page [NG00067](https://dss.niagads.org/datasets/ng00067/)
. Information about what is needed for a Data Access Request can be found on the [Application Instructions](https://dss.niagads.org/documentation/applying-for-data/application-instructions/)
 page.

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