---
title: "A4 Study (A4)"
id: "4248"
type: "cohort"
slug: "a4-study-a4"
published_at: "2022-12-13T18:08:49+00:00"
modified_at: "2025-05-21T13:35:39+00:00"
url: "https://dss.niagads.org/cohorts/a4-study-a4/"
markdown_url: "https://dss.niagads.org/cohorts/a4-study-a4.md"
excerpt: "The A4 Study was designed as a three-year, placebo-controlled, randomized clinical trial to test whether anti-amyloid treatment can slow the rate of cognitive decline in older individuals from diverse ethnic-racial backgrounds (non-Hispanic White, African American and Latino/Hispanic) with evidence of..."
taxonomy_cohort_categories:
  - "ADSP"
taxonomy_cohort_countries:
  - "Australia"
  - "Canada"
  - "Japan"
  - "United States of America"
---

Website:

[https://www.a4studydata.org/](https://www.a4studydata.org/)

## Description

The**[A4 Study](https://a4study.org/)** was designed as a three-year, placebo-controlled, randomized clinical trial to test whether anti-amyloid treatment can slow the rate of cognitive decline in older individuals from diverse ethnic-racial backgrounds (non-Hispanic White, African American and Latino/Hispanic) with evidence of amyloid accumulation on screening PET scans.

## Related Datasets

- [NG00067 – ADSP Umbrella](https://dss.niagads.org/datasets/ng00067/) This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common… [Learn more](https://dss.niagads.org/datasets/ng00067/)

## Related Studies

- [sa000001 - Alzheimer’s Disease Sequencing Project (ADSP)](https://dss.niagads.org/studies/sa000001/) Background An initiative in response to the National Alzheimer’s Project Act (NAPA) has been working towards new biological insights and cures for Alzheimer’s Disease (AD) since its introduction by NIH… [Learn more](https://dss.niagads.org/studies/sa000001/)

## Related Sample Sets

- [snd10094 - ADSP-FUS3 WGS](https://dss.niagads.org/sample-sets/snd10094/) The ADSP-FUS is a National Institute on Aging (NIA) initiative focused on identifying genetic risk and protective variants for late-onset Alzheimer Disease (LOAD). A concern in AD genetic studies is… [Learn more](https://dss.niagads.org/sample-sets/snd10094/)

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