---
title: "Alzheimer’s Disease Neuroimaging Initiative (ADNI)"
id: "942"
type: "cohort"
slug: "alzheimers-disease-neuroimaging-initiative-adni"
published_at: "2019-06-17T20:16:47+00:00"
modified_at: "2024-09-13T19:50:21+00:00"
url: "https://dss.niagads.org/cohorts/alzheimers-disease-neuroimaging-initiative-adni/"
markdown_url: "https://dss.niagads.org/cohorts/alzheimers-disease-neuroimaging-initiative-adni.md"
excerpt: "ADNI is a global research study that actively supports the investigation and development of treatments that slow or stop the progression of AD. In this multisite longitudinal study, researchers at 63 sites in the US and Canada track the progression..."
taxonomy_cohort_categories:
  - "ADSP"
taxonomy_cohort_countries:
  - "Canada"
  - "United States of America"
---

Website:

[https://adni.loni.usc.edu/](https://adni.loni.usc.edu/)

## Description

ADNI is a global research study that actively supports the investigation and development of treatments that slow or stop the progression of AD. In this multisite longitudinal study, researchers at 63 sites in the US and Canada track the progression of AD in the human brain with clinical, imaging, genetic and biospecimen biomarkers through the process of normal aging, early mild cognitive impairment (EMCI), and late mild cognitive impairment (LMCI) to dementia or AD. Participants undergo a series of initial tests that are repeated at intervals over subsequent years, including a clinical evaluation, neuropsychological tests, genetic testing, lumbar puncture, and MRI and PET scans. The overall goal of ADNI is to validate biomarkers for use in Alzheimer’ s disease clinical treatment trials. 1338 cases and 483 controls are included in this study across 4 phases.

## Related Datasets

- [NG00067 – ADSP Umbrella](https://dss.niagads.org/datasets/ng00067/) This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common… [Learn more](https://dss.niagads.org/datasets/ng00067/)

## Related Studies

- [sa000002 - Alzheimer’s Disease Neuroimaging Initiative (ADNI)](https://dss.niagads.org/studies/sa000002/) The Alzheimer’s Disease Neuroimaging Initiative (ADNI) is a longitudinal multicenter study designed to develop clinical, imaging, genetic, and biochemical biomarkers for the early detection and tracking of Alzheimer’s disease (AD).… [Learn more](https://dss.niagads.org/studies/sa000002/)
- [sa000001 - Alzheimer’s Disease Sequencing Project (ADSP)](https://dss.niagads.org/studies/sa000001/) Background An initiative in response to the National Alzheimer’s Project Act (NAPA) has been working towards new biological insights and cures for Alzheimer’s Disease (AD) since its introduction by NIH… [Learn more](https://dss.niagads.org/studies/sa000001/)

## Related Sample Sets

- [snd10002 - ADNI-WGS-1](https://dss.niagads.org/sample-sets/snd10002/) Whole Genome Sequencing Data In July 2012, the Brin-Wojcicki Foundation and the Alzheimer’s Association donated funds to support whole genome sequencing (WGS) of 818 ADNI participants (at the time: 128… [Learn more](https://dss.niagads.org/sample-sets/snd10002/)
- [snd10020 - ADSP FUS1 WGS](https://dss.niagads.org/sample-sets/snd10020/) The ADSP-FUS is a National Institute on Aging (NIA) initiative focused on identifying genetic risk and protective variants for late-onset Alzheimer Disease (LOAD). A concern in AD genetic studies is… [Learn more](https://dss.niagads.org/sample-sets/snd10020/)
- [snd10094 - ADSP-FUS3 WGS](https://dss.niagads.org/sample-sets/snd10094/) The ADSP-FUS is a National Institute on Aging (NIA) initiative focused on identifying genetic risk and protective variants for late-onset Alzheimer Disease (LOAD). A concern in AD genetic studies is… [Learn more](https://dss.niagads.org/sample-sets/snd10094/)

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