---
title: "Cache County Study (CCS)"
id: "2382"
type: "cohort"
slug: "cache-county-study-ccs"
published_at: "2021-02-24T00:32:00+00:00"
modified_at: "2024-09-13T20:00:03+00:00"
url: "https://dss.niagads.org/cohorts/cache-county-study-ccs/"
markdown_url: "https://dss.niagads.org/cohorts/cache-county-study-ccs.md"
excerpt: "The Cache County Study on Memory Health and Aging (CCS) was initiated in 1994 to investigate the association of APOE genotype and environmental exposures on cognitive function and dementia. This cohort of 5092 Cache County, Utah, residents (90% of those..."
taxonomy_cohort_categories:
  - "ADSP"
taxonomy_cohort_countries:
  - "United States of America"
---

## Description

The Cache County Study on Memory Health and Aging (CCS) was initiated in 1994 to investigate the association of APOE genotype and environmental exposures on cognitive function and dementia. This cohort of 5092 Cache County, Utah, residents (90% of those aged 65 years or older in 1994), has been followed continuously for over 15 years, with four triennial waves of data collection and additional clinical assessments for those at high-risk for dementia. DNA samples were obtained from 97.6% of participants. The Cache County population is exceptionally long-lived and ranked number one in life expectancy among all counties in the 1990 US Census. All but one of the members of the CCS have been linked to the UPDB and their extended genealogies are known. This population was the source of most of the Centre d’Etude du Polymorphisme Humain (CEPH) families that have been used to represent Caucasians in many genetic studies worldwide, including the HapMap project. Recent analyses confirm that these data are representative of the general European-American population. For this study, we needed both AD cases and resilient individuals identified in the same pedigrees.” (Ridge, P.G., Karch, C.M., Hsu, S. et al. Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience. Genome Med 9, 100 (2017). https://doi.org/10.1186/s13073-017-0486-1)

## Related Datasets

- [NG00067 – ADSP Umbrella](https://dss.niagads.org/datasets/ng00067/) This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common… [Learn more](https://dss.niagads.org/datasets/ng00067/)

## Related Studies

- [sa000014 - Cache County Study](https://dss.niagads.org/studies/sa000014/) Investigators for this study report the development and use of an innovative, powerful approach to identify functional variants that provide AD resilience to high-risk individuals. In this study, pedigrees were… [Learn more](https://dss.niagads.org/studies/sa000014/)

## Related Sample Sets

- [snd10014 - Cache County WGS](https://dss.niagads.org/sample-sets/snd10014/) Cache County samples were whole-genome sequenced at Illumina on the HiSeq2000 machine. BAM from hg37 build were sent to GCAD for processing on the VCPA1.1 pipeline. 207 samples passed sequencing… [Learn more](https://dss.niagads.org/sample-sets/snd10014/)

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