---
title: "Corticobasal Degeneration (CBD)"
id: "1766"
type: "cohort"
slug: "corticobasal-degeneration-cbd"
published_at: "2020-02-19T19:18:37+00:00"
modified_at: "2024-09-18T16:31:44+00:00"
url: "https://dss.niagads.org/cohorts/corticobasal-degeneration-cbd/"
markdown_url: "https://dss.niagads.org/cohorts/corticobasal-degeneration-cbd.md"
excerpt: "Patients with a clinical Parkinsonism in life and neuropathological confirmation of Corticobasal Degeneration (CBD) were identified from brain banks, research hospitals and neuropathologists. The top three contributing sites were the Mayo Clinic, University College London, and the University of Pennsylvania..."
taxonomy_cohort_categories:
  - "ADSP"
taxonomy_cohort_countries:
  - "Australia"
  - "Germany"
  - "Spain"
  - "United Kingdom"
  - "United States of America"
---

## Description

Patients with a clinical Parkinsonism in life and neuropathological confirmation of Corticobasal Degeneration (CBD) were identified from brain banks, research hospitals and neuropathologists. The top three contributing sites were the Mayo Clinic, University College London, and the University of Pennsylvania and additional small numbers of cases were obtained from various other institutions across the US and some international collaborators. The neuropathological diagnosis was made according to NINDS neuropathologic diagnostic criteria. DNA was extracted from brain tissue from patients who had consented for brain donation. DNA samples and/or tissue were sent to the University of Pennsylvania for preparation for genotyping.

## Related Datasets

- [NG00067 – ADSP Umbrella](https://dss.niagads.org/datasets/ng00067/) This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common… [Learn more](https://dss.niagads.org/datasets/ng00067/)
- [NG00176-CNVs from ADSP WES data using CANOES software](https://dss.niagads.org/datasets/ng00176/) This dataset contains Copy Number Variation (CNV) calling from the Whole Exome Sequencing (WES) from multiple distinct Alzheimer Disease (AD) sequencing projects: both discovery and replication ADSP family dataset, ADSP… [Learn more](https://dss.niagads.org/datasets/ng00176/)

## Related Studies

- [sa000009 - Corticobasal degeneration Study (CBD)](https://dss.niagads.org/studies/sa000009/) Corticobasal degeneration (CBD) is a rare neurodegenerative disorder of unknown etiology. The genetics of CBD are largely unknown. To identify genes and rare variants that cause or increase risk for… [Learn more](https://dss.niagads.org/studies/sa000009/)
- [sa000081 - Extremely Rare CNVs and Alzheimer’s Disease Risk: Analysis of ADSP WES Data](https://dss.niagads.org/studies/sa000081/) The purpose of this study is to find new Alzheimer related variants and genes, by combining exome data from healthy controls and Alzheimer patients from different studies. CNV calling was… [Learn more](https://dss.niagads.org/studies/sa000081/)
- [sa000010 - Progressive Supranuclear Palsy Study (PSP)](https://dss.niagads.org/studies/sa000010/) Progressive supranuclear palsy (PSP) is a brain disease with tau aggregates in neurons, oligodendrocytes, and astrocytes. Previous work identified two genetic variants that elevate PSP risk. This study used whole… [Learn more](https://dss.niagads.org/studies/sa000010/)

## Related Sample Sets

- [snd10009 - CBD WES](https://dss.niagads.org/sample-sets/snd10009/) Corticobasal degeneration samples were sequenced at Children's Hospital of Philadelphia (CHOP) on the HiSeq2500 machine. 361 samples were sequenced using the Agilent WES v5 capture region target capture kit. FASTQ… [Learn more](https://dss.niagads.org/sample-sets/snd10009/)
- [snd10010 - PSP WES](https://dss.niagads.org/sample-sets/snd10010/) Progressive supranuclear palsy samples were sequenced at FGC, IDOM and PGFI at University of Pennsylvania on the HiSeq2000/2500 machine. 705 samples were sequenced using Roche Nimblegen's VCRome v2.1, target capture… [Learn more](https://dss.niagads.org/sample-sets/snd10010/)
- [snd10139 - CNV Calling from ADSP Whole-Exome Sequencing (WES) Data](https://dss.niagads.org/sample-sets/snd10139/) This dataset comprises CNV calls from Whole Exome Sequencing (WES) across multiple distinct Alzheimer’s Disease (AD) sequencing projects, including the discovery and replication ADSP family datasets, the ADSP case-control dataset,… [Learn more](https://dss.niagads.org/sample-sets/snd10139/)

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