---
title: "Genetic and Environmental Risk Factors for Alzheimer’s Disease Among African Americans (GenerAAtions)"
id: "1012"
type: "cohort"
slug: "genetic-and-environmental-risk-factors-for-alzheimers-disease-among-african-americans-generaations"
published_at: "2020-02-19T15:07:53+00:00"
modified_at: "2024-09-18T16:36:22+00:00"
url: "https://dss.niagads.org/cohorts/genetic-and-environmental-risk-factors-for-alzheimers-disease-among-african-americans-generaations/"
markdown_url: "https://dss.niagads.org/cohorts/genetic-and-environmental-risk-factors-for-alzheimers-disease-among-african-americans-generaations.md"
excerpt: "Participants of the GenerAAtions Study were identified through the electronic claims database of the Henry Ford Health System. Community-dwelling African Americans aged 65 and older who had at least one encounter with the Henry Ford Health System in the three..."
taxonomy_cohort_categories:
  - "ADSP"
taxonomy_cohort_countries:
  - "United States of America"
---

## Description

Participants of the GenerAAtions Study were identified through the electronic claims database of the Henry Ford Health System. Community-dwelling African Americans aged 65 and older who had at least one encounter with the Henry Ford Health System in the three years prior to their recruitment and who had an available proxy informant were eligible for this study. Cases met NINCDS-ADRDA criteria for possible or probable AD, determined in a consensus conference which included a behavioral neurologist, psychiatrist, neuropsychologist, and a behavioral neurology nurse practitioner. Phenotypic data were available for 242 AD cases and 204 cognitively normal controls.

## Related Datasets

- [NG00067 – ADSP Umbrella](https://dss.niagads.org/datasets/ng00067/) This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common… [Learn more](https://dss.niagads.org/datasets/ng00067/)

## Related Studies

- [sa000003 - Alzheimer’s Disease Genetics Consortium (ADGC)](https://dss.niagads.org/studies/sa000003/) The ADGC is a large U.S. based consortium formed to collaboratively use the collective resources of the AD research community to resolve Alzheimer’s disease (AD) genetics. Working with the National… [Learn more](https://dss.niagads.org/studies/sa000003/)

## Related Sample Sets

- [snd10003 - ADGC AA WES](https://dss.niagads.org/sample-sets/snd10003/) ADGC African American samples were sequenced at University of Miami on the HiSeq3000 machine. 3226 samples were sequenced using the Agilent WES v6 target capture kit. BAM files from hg37… [Learn more](https://dss.niagads.org/sample-sets/snd10003/)

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