---
title: "Indianapolis-Ibadan (IIAA/IIBD)"
id: "952"
type: "cohort"
slug: "indianapolis-ibadan-iiaa"
published_at: "2019-06-17T20:19:01+00:00"
modified_at: "2025-05-19T21:11:41+00:00"
url: "https://dss.niagads.org/cohorts/indianapolis-ibadan-iiaa/"
markdown_url: "https://dss.niagads.org/cohorts/indianapolis-ibadan-iiaa.md"
excerpt: "The Indianapolis-Ibadan Dementia Project, established in 1991, is a longitudinal prospective population-based comparative epidemiological study of the prevalence and incidence rates and risk factors for Alzheimer’s disease and other age associated dementias. Enrollment of community-dwelling elderly (age>65 years) African Americans..."
taxonomy_cohort_categories:
  - "ADSP"
taxonomy_cohort_countries:
  - "Nigeria"
  - "United States of America"
---

Website:

[https://iidpportal.medicine.iu.edu/](https://iidpportal.medicine.iu.edu/)

## Description

The Indianapolis-Ibadan Dementia Project, established in 1991, is a longitudinal prospective population-based comparative epidemiological study of the prevalence and incidence rates and risk factors for Alzheimer’s disease and other age associated dementias. Enrollment of community-dwelling elderly (age>65 years) African Americans living in Indianapolis and Yoruba living in Ibadan, Nigeria employed the same research design, methods, and investigators (see study description at [https://iidpportal.medicine.iu.edu/](https://iidpportal.medicine.iu.edu/)
). The first enrollment wave began in 1992 and participants were followed every 2 to 3 years.

Participants were ascertained and evaluated through community centers, clinical and hospital settings as well in community centers and at home. All participants greater than 65 years of age who agreed to participate were screened using measures. Those who failed the screen underwent a more comprehensive clinical evaluation. Medical and family history interview, neuropsychological testing, behavioral and emotional assessments, and functional measures, including collateral informant report, were available for all most participants. Venous blood samples (were collected on all participants. All assessments were conducted in the preferred language of the participant or knowledgeable informant. Finally, all participants were adjudicated by a clinical consensus panel and were classified according to various criteria in place at the time of the clinical data collection Details on diagnosis criteria and process were described in Hendrie et al JAMA 2001.

## Related Datasets

- [NG00067 – ADSP Umbrella](https://dss.niagads.org/datasets/ng00067/) This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common… [Learn more](https://dss.niagads.org/datasets/ng00067/)
- [NG00116 – Resolving Mutations in Challenging Genomic Regions to Test Association with Disease Phenotypes](https://dss.niagads.org/datasets/ng00116/) Many regions of the human genome present challenges that prohibit scientists from discovering potential disease-causing mutations. We developed methods to characterize mutations in these regions to rescue mutations that are… [Learn more](https://dss.niagads.org/datasets/ng00116/)

## Related Studies

- [sa000001 - Alzheimer’s Disease Sequencing Project (ADSP)](https://dss.niagads.org/studies/sa000001/) Background An initiative in response to the National Alzheimer’s Project Act (NAPA) has been working towards new biological insights and cures for Alzheimer’s Disease (AD) since its introduction by NIH… [Learn more](https://dss.niagads.org/studies/sa000001/)
- [sa000042 - Resolving mutations in challenging genomic regions to test association with disease phenotypes](https://dss.niagads.org/studies/sa000042/) Many regions of the human genome present challenges that prohibit scientists from discovering potential disease causing mutations. We developed methods to characterize mutations in these regions to rescue mutations that… [Learn more](https://dss.niagads.org/studies/sa000042/)

## Related Sample Sets

- [snd10001 - ADSP Extension](https://dss.niagads.org/sample-sets/snd10001/) The ADSP Discovery Family-Based Extension Study: To further assess the genomes in multiply affected families, under funding provided by NHGRI, an additional 427 samples were whole genome sequenced. This included… [Learn more](https://dss.niagads.org/sample-sets/snd10001/)
- [snd10031 - ADSP-FUS2 WGS](https://dss.niagads.org/sample-sets/snd10031/) The ADSP-FUS is a National Institute on Aging (NIA) initiative focused on identifying genetic risk and protective variants for late-onset Alzheimer Disease (LOAD). A concern in AD genetic studies is… [Learn more](https://dss.niagads.org/sample-sets/snd10031/)
- [snd10074 - Camouflaged Variants](https://dss.niagads.org/sample-sets/snd10074/) Provided here are variant calls in VCF format for 14,526 samples derived from the ADSP whole-exome and whole-genome sequencing dataset (available via DSS: NG00067). [Learn more](https://dss.niagads.org/sample-sets/snd10074/)

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