---
title: "Mexico-Southern California Autosomal Dominant Alzheimer’s Disease Consortium"
id: "5033"
type: "cohort"
slug: "mexico-southern-california-autosomal-dominant-alzheimers-disease-consortium"
published_at: "2023-08-02T18:50:57+00:00"
modified_at: "2024-11-27T16:13:47+00:00"
url: "https://dss.niagads.org/cohorts/mexico-southern-california-autosomal-dominant-alzheimers-disease-consortium/"
markdown_url: "https://dss.niagads.org/cohorts/mexico-southern-california-autosomal-dominant-alzheimers-disease-consortium.md"
excerpt: "Participants include persons of Mexican origin affected by or known to be at 50% risk for the development of autosomal dominant Alzheimer’s disease (ADAD) due to the A431E mutation in PSEN1 or the V717I mutation in APP. This includes legacy..."
taxonomy_cohort_categories:
  - "ADSP"
taxonomy_cohort_countries:
  - "Mexico"
  - "United States of America"
---

## Description

Participants include persons of Mexican origin affected by or known to be at 50% risk for the development of autosomal dominant Alzheimer’s disease (ADAD) due to the A431E mutation in *PSEN1* or the V717I mutation in *APP*. This includes legacy DNA and data collected prior to funding and prospective data being collected under NIH/NIA/FIC, R01AG069013, “Phenotype and Genotype of Autosomal Dominant Alzheimer’s Disease in Jalisco, Mexico.”

Prospective participants are enrolled in Guadalajara or Los Angeles and undergo the UDS3, becoming part of the ADRC of the University of Southern California (USC) with their UDS packets submitted to the National Alzheimer Coordinating Center (NACC). They are then followed annually using this protocol and those in Los Angeles asked to participate in the brain autopsy program of the USC ADRC. Additional clinical data and resources (e.g. blood samples, imaging) are variably available for participants.

## Related Datasets

- [NG00067 – ADSP Umbrella](https://dss.niagads.org/datasets/ng00067/) This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common… [Learn more](https://dss.niagads.org/datasets/ng00067/)

## Related Studies

- [sa000001 - Alzheimer’s Disease Sequencing Project (ADSP)](https://dss.niagads.org/studies/sa000001/) Background An initiative in response to the National Alzheimer’s Project Act (NAPA) has been working towards new biological insights and cures for Alzheimer’s Disease (AD) since its introduction by NIH… [Learn more](https://dss.niagads.org/studies/sa000001/)

## Related Sample Sets

- [snd10094 - ADSP-FUS3 WGS](https://dss.niagads.org/sample-sets/snd10094/) The ADSP-FUS is a National Institute on Aging (NIA) initiative focused on identifying genetic risk and protective variants for late-onset Alzheimer Disease (LOAD). A concern in AD genetic studies is… [Learn more](https://dss.niagads.org/sample-sets/snd10094/)

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