--- title: "National Centralized Repository for Alzheimer’s Disease and Related Dementias Family (NCRAD Family)" id: "969" type: "cohort" slug: "national-centralized-repository-for-alzheimers-disease-and-related-dementias-family-ncrad-family" published_at: "2019-06-17T20:20:04+00:00" modified_at: "2024-09-18T17:14:25+00:00" url: "https://dss.niagads.org/cohorts/national-centralized-repository-for-alzheimers-disease-and-related-dementias-family-ncrad-family/" markdown_url: "https://dss.niagads.org/cohorts/national-centralized-repository-for-alzheimers-disease-and-related-dementias-family-ncrad-family.md" excerpt: "The National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD) family cohort was started in 1990 and consists of families with two or more members with early or late onset AD and related dementias. This collection maintains DNA and..." taxonomy_cohort_categories: - "ADSP" taxonomy_cohort_countries: - "United States of America" --- Website: [https://ncrad.iu.edu/accessing_data.html](https://ncrad.iu.edu/accessing_data.html) ## Description The National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD) family cohort was started in 1990 and consists of families with two or more members with early or late onset AD and related dementias. This collection maintains DNA and cell lines on affected family members and unaffected relatives (typically over age 60). These families are not evaluated in person and all clinical information is obtained through medical record review. Therefore, data is limited to the following: family history; demographic data; medical records on the evaluation; diagnosis and treatment of symptomatic subjects; telephone cognitive battery; neuropathological findings when available. This is a longitudinal study with autopsy available to all participants. Genomic DNA, Cell Line DNA, Lymphoblastoid Cell Lines (LCLs), and PBMCs are available. Fixed and/or frozen brain tissue is available on all individuals as well. ## Related Datasets - [NG00020 – NIA AD-FBS GWAS](https://dss.niagads.org/datasets/ng00020/) The goal of the National Institute of Aging Alzheimer’s Disease Family Based Study, NIA AD-FBS (formerly National Institute on Aging Genetics Initiative for Late-Onset Alzheimer’s Disease, NIA-LOAD) is to identify… [Learn more](https://dss.niagads.org/datasets/ng00020/) - [NG00067 – ADSP Umbrella](https://dss.niagads.org/datasets/ng00067/) This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common… [Learn more](https://dss.niagads.org/datasets/ng00067/) - [NG00116 – Resolving Mutations in Challenging Genomic Regions to Test Association with Disease Phenotypes](https://dss.niagads.org/datasets/ng00116/) Many regions of the human genome present challenges that prohibit scientists from discovering potential disease-causing mutations. We developed methods to characterize mutations in these regions to rescue mutations that are… [Learn more](https://dss.niagads.org/datasets/ng00116/) - [NG00117 – NCRAD Families GWAS](https://dss.niagads.org/datasets/ng00117/) The NCRAD Families sample set was genotyped at the Children’s Hospital of Philadelphia using the Illumina Infinium GSAMD-24v2-0_20024620_A1 BeadChip which captures genotype data on 759,993 genomic SNPs. These families are… [Learn more](https://dss.niagads.org/datasets/ng00117/) - [NG00129 – NCRAD Families WES](https://dss.niagads.org/datasets/ng00129/) This ADSP release, containing 170 whole-exomes includes 1) sequencing read alignments in CRAM (compressed BAM) format for the newly sequenced 170 samples, (2) genomic Variant Call Format (gVCF) files generated… [Learn more](https://dss.niagads.org/datasets/ng00129/) - [NG00176-CNVs from ADSP WES data using CANOES software](https://dss.niagads.org/datasets/ng00176/) This dataset contains Copy Number Variation (CNV) calling from the Whole Exome Sequencing (WES) from multiple distinct Alzheimer Disease (AD) sequencing projects: both discovery and replication ADSP family dataset, ADSP… [Learn more](https://dss.niagads.org/datasets/ng00176/) ## Related Studies - [sa000001 - Alzheimer’s Disease Sequencing Project (ADSP)](https://dss.niagads.org/studies/sa000001/) Background An initiative in response to the National Alzheimer’s Project Act (NAPA) has been working towards new biological insights and cures for Alzheimer’s Disease (AD) since its introduction by NIH… [Learn more](https://dss.niagads.org/studies/sa000001/) - [sa000013 - APOE Extremes WGS Study](https://dss.niagads.org/studies/sa000013/) The APOE extremes whole genome sequencing (WGS) study entails Alzheimer’s disease (AD) case-control association analysis using an age extremes sampling approach stratified by APOE genotype, comparing younger onset AD cases… [Learn more](https://dss.niagads.org/studies/sa000013/) - [sa000005 - Brkanac – Family-based genome scan for AAO of LOAD](https://dss.niagads.org/studies/sa000005/) In this study, a family-based genome-wide association study was performed for AAO of late-onset AD in whole exome sequence data generated in multigenerational families with multiple AD cases (n=77). Single… [Learn more](https://dss.niagads.org/studies/sa000005/) - [sa000023 - Dissecting the Genomic Etiology of non-Mendelian Early-Onset Alzheimer Disease (EOAD) and Related Phenotypes](https://dss.niagads.org/studies/sa000023/) Background: Genomic studies of Alzheimer’s disease (AD) have primarily focused on non-Hispanic White (NHW) participants affected by the late-onset form of the disease (LOAD; onset age: >65), or the study… [Learn more](https://dss.niagads.org/studies/sa000023/) - [sa000081 - Extremely Rare CNVs and Alzheimer’s Disease Risk: Analysis of ADSP WES Data](https://dss.niagads.org/studies/sa000081/) The purpose of this study is to find new Alzheimer related variants and genes, by combining exome data from healthy controls and Alzheimer patients from different studies. CNV calling was… [Learn more](https://dss.niagads.org/studies/sa000081/) - [sa000056 - Genetic Studies of Alzheimer’s Disease in Korea](https://dss.niagads.org/studies/sa000056/) Alzheimer disease (AD), the most common neurodegenerative disease in the world, affects individuals of all races and ethnicities; however, most research about factors contributing to risk of AD has been… [Learn more](https://dss.niagads.org/studies/sa000056/) - [sa000063 - National Institute of Aging Alzheimer’s Disease Family Based Study (NIA AD-FBS)](https://dss.niagads.org/studies/sa000063/) The National Institute on Aging Alzheimer's Disease Family Based Study (NIA AD-FBS) is the largest collection of multiplex AD families recruited and longitudinally assessed worldwide. Since 2003, the central goal… [Learn more](https://dss.niagads.org/studies/sa000063/) - [sa000025 - NCRAD Family Study](https://dss.niagads.org/studies/sa000025/) The NCRAD Family Study began in 1990 and continues to actively recruit and follow subjects. Families with two or more living, biologically related, members with early or late onset AD… [Learn more](https://dss.niagads.org/studies/sa000025/) - [sa000042 - Resolving mutations in challenging genomic regions to test association with disease phenotypes](https://dss.niagads.org/studies/sa000042/) Many regions of the human genome present challenges that prohibit scientists from discovering potential disease causing mutations. We developed methods to characterize mutations in these regions to rescue mutations that… [Learn more](https://dss.niagads.org/studies/sa000042/) - [sa000019 - The Diagnostic Assessment of Dementia for the Longitudinal Aging Study of India (LASI-DAD)](https://dss.niagads.org/studies/sa000019/) The Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) is an add-on study to the Longitudinal Aging Study in India (LASI) focused on late-life cognition… [Learn more](https://dss.niagads.org/studies/sa000019/) - [sa000004 - The Familial Alzheimer Sequencing (FASe) project](https://dss.niagads.org/studies/sa000004/) GWAS studies were very successful in identifying genetic loci associated with AD risk. However, these studies could not point to the actual causal variant. In this study, WES and/or WGS… [Learn more](https://dss.niagads.org/studies/sa000004/) ## Related Sample Sets - [snd10000 - ADSP Discovery](https://dss.niagads.org/sample-sets/snd10000/) The initial phase of the ADSP research plan is called the Discovery Phase. Samples were selected from well-characterized study cohorts of individuals with or without an AD diagnosis and the… [Learn more](https://dss.niagads.org/sample-sets/snd10000/) - [snd10001 - ADSP Extension](https://dss.niagads.org/sample-sets/snd10001/) The ADSP Discovery Family-Based Extension Study: To further assess the genomes in multiply affected families, under funding provided by NHGRI, an additional 427 samples were whole genome sequenced. This included… [Learn more](https://dss.niagads.org/sample-sets/snd10001/) - [snd10004 - FASe Families WES](https://dss.niagads.org/sample-sets/snd10004/) FASe Family samples were sequenced at Genentech, MGI and Otogenetics on the HiSeq2000 machine. 715 samples were sequenced using the Agilent WES v5 capture region, 164 samples were using the… [Learn more](https://dss.niagads.org/sample-sets/snd10004/) - [snd10005 - Brkanac Families WES](https://dss.niagads.org/sample-sets/snd10005/) This is a family design study. Samples were sequenced at Department of Genome Sciences, University of Washington on the HiSeq2000 machine. 77 samples were sequenced using the Roche SeqCap EZ… [Learn more](https://dss.niagads.org/sample-sets/snd10005/) - [snd10018 - FASe_Families WGS](https://dss.niagads.org/sample-sets/snd10018/) FASe_WGS samples were whole-genome sequenced at Broad either on the HiSeqX or HiSeq2000/2500 machine. Samples in either format (BAM files from hg37 build and FASTQ files) were sent to GCAD… [Learn more](https://dss.niagads.org/sample-sets/snd10018/) - [snd10031 - ADSP-FUS2 WGS](https://dss.niagads.org/sample-sets/snd10031/) The ADSP-FUS is a National Institute on Aging (NIA) initiative focused on identifying genetic risk and protective variants for late-onset Alzheimer Disease (LOAD). A concern in AD genetic studies is… [Learn more](https://dss.niagads.org/sample-sets/snd10031/) - [snd10033 - LASI-DAD WGS](https://dss.niagads.org/sample-sets/snd10033/) 2,768 LASI-DAD respondents from 18 diverse ethno-linguistic and genographic groups across India who consented to the blood sample collection samples were sequenced at Medgenome on the HiSeqX machine. FASTQ files… [Learn more](https://dss.niagads.org/sample-sets/snd10033/) - [snd10037 - NCRAD Families GWAS GSA](https://dss.niagads.org/sample-sets/snd10037/) The NCRAD Family Study began in 1990 and continues to actively recruit and follow subjects. Families with two or more living, biologically related, members with early or late onset AD… [Learn more](https://dss.niagads.org/sample-sets/snd10037/) - [snd10039 - NCRAD Families WES](https://dss.niagads.org/sample-sets/snd10039/) This sample set includes WES data on 170 sequenced subjects. Phenotype data also includes connecting family data for the sequenced subjects. [Learn more](https://dss.niagads.org/sample-sets/snd10039/) - [snd10074 - Camouflaged Variants](https://dss.niagads.org/sample-sets/snd10074/) Provided here are variant calls in VCF format for 14,526 samples derived from the ADSP whole-exome and whole-genome sequencing dataset (available via DSS: NG00067). [Learn more](https://dss.niagads.org/sample-sets/snd10074/) - [snd10092 - GARD1 WGS](https://dss.niagads.org/sample-sets/snd10092/) This sample dataset was collected from the GARD cohort. 2,002 participants and 5 replicates were sequenced by DNALINK using Illumina NovaSeq 6000 sequencing technology. FASTQ and CRAM files were sent… [Learn more](https://dss.niagads.org/sample-sets/snd10092/) - [snd10095 - EOAD2 WGS](https://dss.niagads.org/sample-sets/snd10095/) 1,264 samples were sequenced at USUHS on the NovaSeq machine. FASTQ files were sent to GCAD for processing on the VCPA 1.1 pipeline. A total of 1,183 samples passed sequencing… [Learn more](https://dss.niagads.org/sample-sets/snd10095/) - [snd10101 - FASe-Families2 WGS](https://dss.niagads.org/sample-sets/snd10101/) 659 samples were sequenced by USUHS and Macrogen on the NovaSeq and Illumina HiSeq 2500 platform. GCAD received FASTQ and CRAM files for processing. A total of 646 samples passed… [Learn more](https://dss.niagads.org/sample-sets/snd10101/) - [snd10103 - APOEExtremes1 WGS](https://dss.niagads.org/sample-sets/snd10103/) 27 samples were sequenced at Genentech on Illumina HiSeqX and Illumina platforms. CRAM files were sent to GCAD for processing. A total of 21 samples passed sequencing metrics and quality… [Learn more](https://dss.niagads.org/sample-sets/snd10103/) - [snd10139 - CNV Calling from ADSP Whole-Exome Sequencing (WES) Data](https://dss.niagads.org/sample-sets/snd10139/) This dataset comprises CNV calls from Whole Exome Sequencing (WES) across multiple distinct Alzheimer’s Disease (AD) sequencing projects, including the discovery and replication ADSP family datasets, the ADSP case-control dataset,… [Learn more](https://dss.niagads.org/sample-sets/snd10139/) - [snd10144 - NIA AD-FBS GWAS](https://dss.niagads.org/sample-sets/snd10144/) Genotyping done by the Center for Inherited Disease Research (CIDR) was performed using the Illumina Infinium II assay protocol with hybridization to Illumina Human 610Quadv1_B Beadchips. When first deposited in… [Learn more](https://dss.niagads.org/sample-sets/snd10144/) ```