---
title: "NIH Neurobiobank/University of Maryland (UMB-BTB)"
id: "3585"
type: "cohort"
slug: "nih-neurobiobank-university-of-maryland"
published_at: "2022-05-11T16:00:58+00:00"
modified_at: "2024-09-18T17:30:44+00:00"
url: "https://dss.niagads.org/cohorts/nih-neurobiobank-university-of-maryland/"
markdown_url: "https://dss.niagads.org/cohorts/nih-neurobiobank-university-of-maryland.md"
excerpt: "The National Institutes of Health have established and funded a network of six Brain and Tissue Banks referred to as the NIH NeuroBioBank. Each of the banks collects and distributes tissue from donors with neurodevelopmental, neurodegenerative, and psychiatric disorders as..."
taxonomy_cohort_countries:
  - "United States of America"
---

Website:

[https://www.medschool.umaryland.edu/btbank/](https://www.medschool.umaryland.edu/btbank/)

## Description

The National Institutes of Health have established and funded a network of six Brain and Tissue Banks referred to as the NIH NeuroBioBank. Each of the banks collects and distributes tissue from donors with neurodevelopmental, neurodegenerative, and psychiatric disorders as well as control donors lacking any clinical brain diagnosis. The UMB Brain and Tissue Bank is located at the University of Maryland School of Medicine, Department of Pediatrics in Baltimore, Maryland. It was formerly the “NICHD Brain and Tissue Bank for Developmental Disorders” until becoming part of the NIH NeuroBioBank.  
The mission of the UMB BTB is to advance the research of developmental, neurologic and movement disorders. The objective of this human tissue repository is to systematically collect, store, and distribute brain and other tissues for research dedicated to the improved understanding, care and treatment of individuals with these disorders.

## Related Datasets

- [NG00121 – Alzheimer’s disease single-neuron whole-genome sequencing – Miller 2022](https://dss.niagads.org/datasets/ng00121/) Single-neuron amplified genome libraries were sequenced (WGS) on Illumina instruments and aligned to the human reference genome GRCh37. Linked-read analysis (LiRA) and SCAN-SNV were used to identify single-cell somatic mutations.… [Learn more](https://dss.niagads.org/datasets/ng00121/)
- [NG00162 – Oligodendrocytes single-cell whole genome and RNA sequencing](https://dss.niagads.org/datasets/ng00162/) Characterizing the mechanisms of somatic mutations in the brain is important for understanding aging and disease, but little is known about the mutational patterns of different cell types. We performed… [Learn more](https://dss.niagads.org/datasets/ng00162/)
- [NG00183 – Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy](https://dss.niagads.org/datasets/ng00183/) This study characterized somatic mutations in chronic traumatic encephalopathy (CTE) and performed whole-genome sequencing of single neurons isolated from prefrontal cortex (PFC) of postmortem human brain of individuals with CTE,… [Learn more](https://dss.niagads.org/datasets/ng00183/)

## Related Studies

- [sa000022 - Alzheimer’s disease single-neuron whole-genome sequencing – Miller 2022](https://dss.niagads.org/studies/sa000022/) This study performed whole-genome sequencing of single neurons isolated from prefrontal cortex (PFC) and hippocampus CA1 (HC) of postmortem human brain of individuals with Alzheimer’s disease (AD)(Braak stage V-VI) or… [Learn more](https://dss.niagads.org/studies/sa000022/)
- [sa000075 - Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy](https://dss.niagads.org/studies/sa000075/) This study characterized somatic mutations in chronic traumatic encephalopathy (CTE) and performed whole-genome sequencing of single neurons isolated from prefrontal cortex (PFC) of postmortem human brain of individuals with CTE,… [Learn more](https://dss.niagads.org/studies/sa000075/)
- [sa000051 - Rates and mechanisms of age-related somatic mutation in normal and Alzheimer brain](https://dss.niagads.org/studies/sa000051/) Characterizing the mechanisms of somatic mutations in the brain is important for understanding aging and disease, but little is known about the mutational patterns of different cell types. We performed… [Learn more](https://dss.niagads.org/studies/sa000051/)

## Related Sample Sets

- [snd10029 - Alzheimer’s disease single-neuron whole-genome sequencing – Miller 2022](https://dss.niagads.org/sample-sets/snd10029/) This study performed whole-genome sequencing of single neurons isolated from prefrontal cortex (PFC) and hippocampus CA1 (HC) of postmortem human brain of individuals with Alzheimer’s disease (AD) (Braak stage V-VI)… [Learn more](https://dss.niagads.org/sample-sets/snd10029/)
- [snd10084 - Oligodendrocytes single-cell whole genome and RNA sequencing](https://dss.niagads.org/sample-sets/snd10084/) Characterizing the mechanisms of somatic mutations in the brain is important for understanding aging and disease, but little is known about the mutational patterns of different cell types. We performed… [Learn more](https://dss.niagads.org/sample-sets/snd10084/)
- [snd10128 - Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy](https://dss.niagads.org/sample-sets/snd10128/) This study characterized somatic mutations in chronic traumatic encephalopathy (CTE) and performed whole-genome sequencing of single neurons isolated from prefrontal cortex (PFC) of postmortem human brain of individuals with CTE,… [Learn more](https://dss.niagads.org/sample-sets/snd10128/)

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