---
title: "Puerto Rican 10/66 Study (PR1066)"
id: "2388"
type: "cohort"
slug: "puerto-rican-10-66-study-pr1066"
published_at: "2021-02-24T00:32:41+00:00"
modified_at: "2024-09-18T17:55:22+00:00"
url: "https://dss.niagads.org/cohorts/puerto-rican-10-66-study-pr1066/"
markdown_url: "https://dss.niagads.org/cohorts/puerto-rican-10-66-study-pr1066.md"
excerpt: "The Puerto Rican 10/66 Study (PR1066) (https://www.alz.co.uk/1066/), is an Alzheimer’s Disease International study of dementia in Puerto Rico that began in 2007 (Dr. Ivonne Jimenez-Velazquez, PI). Individuals were recruited as part of the the 10/66 Population Based Study of Dementia..."
taxonomy_cohort_categories:
  - "ADSP"
taxonomy_cohort_countries:
  - "Puerto Rico"
---

## Description

The Puerto Rican 10/66 Study (PR1066) ([https://www.alz.co.uk/1066/](https://nam01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.alz.co.uk%2F1066%2F&data=04%7C01%7CbKunkle%40med.miami.edu%7C42b90ef4de7144a46f8908d8d7342a40%7C2a144b72f23942d48c0e6f0f17c48e33%7C0%7C0%7C637495966336523289%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=7EK7Sj5zKw9bT1cuYk%2FBroBoZEIw4MWdF4TNciE9M1E%3D&reserved=0)
), is an Alzheimer’s Disease International study of dementia in Puerto Rico that began in 2007 (Dr. Ivonne Jimenez-Velazquez, PI). Individuals were recruited as part of the the 10/66 Population Based Study of Dementia using standard protocols. As part of this study, sociodemographic information and detailed clinical history of memory decline were collected. In addition, the Clinical Dementia Rating scale (CDR), and Community Screening Interview for Dementia, and Petersen ADL criteria were collected for all individuals. Neurocognitive testing (CERAD battery) was available for some participants. Participants were adjudicated for dementia. Lastly, the total number of samples that were whole genome sequenced is 1,565 with the breakdown of 140 Cases; 1,245 Controls and 180 MCI’s.

Prince M, Ferri CP, Acosta D, et al. The protocols for the 10/66 dementia research group population- based research programme. *BMC Public Health*. 2007;7(1):165.

## Related Datasets

- [NG00067 – ADSP Umbrella](https://dss.niagads.org/datasets/ng00067/) This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common… [Learn more](https://dss.niagads.org/datasets/ng00067/)
- [NG00196- Genotyping short tandem repeats using the ADSP R4 cohort](https://dss.niagads.org/datasets/ng00196/) A two-step pipeline was used to first identify expanded short tandem repeats (STRs) in ADSP samples using ExpansionHunter Denovo and then genotype the identified STRs, along with additional polymorphic STRs… [Learn more](https://dss.niagads.org/datasets/ng00196/)

## Related Studies

- [sa000001 - Alzheimer’s Disease Sequencing Project (ADSP)](https://dss.niagads.org/studies/sa000001/) Background An initiative in response to the National Alzheimer’s Project Act (NAPA) has been working towards new biological insights and cures for Alzheimer’s Disease (AD) since its introduction by NIH… [Learn more](https://dss.niagads.org/studies/sa000001/)
- [sa000087 - Genotyping short tandem repeats using ADSP R4](https://dss.niagads.org/studies/sa000087/) Variation in tandem repeats (TRs), particularly large expansions of triplet repeats (e.g., polyCAG), is known to cause a number of late-onset neurological diseases. Due to their repetitive and degenerate nature,… [Learn more](https://dss.niagads.org/studies/sa000087/)

## Related Sample Sets

- [snd10020 - ADSP FUS1 WGS](https://dss.niagads.org/sample-sets/snd10020/) The ADSP-FUS is a National Institute on Aging (NIA) initiative focused on identifying genetic risk and protective variants for late-onset Alzheimer Disease (LOAD). A concern in AD genetic studies is… [Learn more](https://dss.niagads.org/sample-sets/snd10020/)
- [snd10147 - ADSP R4 Short Tandem Repeats (STRs)](https://dss.niagads.org/sample-sets/snd10147/) This dataset comprises short tandem repeat (STR) genotypes from 31,681 whole-genome sequencing (WGS) samples from the ADSP R4 data release. The STRs were genotyped using ExpansionHunter with a custom catalog… [Learn more](https://dss.niagads.org/sample-sets/snd10147/)

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