--- title: "Religious Orders Study/Memory and Aging Project (ROSMAP)" id: "996" type: "cohort" slug: "religious-orders-study-memory-and-aging-project-rosmap" published_at: "2020-02-19T15:17:50+00:00" modified_at: "2024-11-25T22:40:03+00:00" url: "https://dss.niagads.org/cohorts/religious-orders-study-memory-and-aging-project-rosmap/" markdown_url: "https://dss.niagads.org/cohorts/religious-orders-study-memory-and-aging-project-rosmap.md" excerpt: "The Religious Orders Study (ROS) is a longitudinal, epidemiologic clinical-pathological study of memory, motor, and functional problems in older Catholic nuns, priests, and brothers aged 65 years and older from across the United States. Participants without known dementia agree to..." taxonomy_cohort_categories: - "ADSP" taxonomy_cohort_countries: - "United States of America" --- Website: [https://www.rushu.rush.edu/research/departmental-research/rush-alzheimers-disease-center/radc-research/epidemologic-research](https://www.rushu.rush.edu/research/departmental-research/rush-alzheimers-disease-center/radc-research/epidemologic-research) ## Description The Religious Orders Study (ROS) is a longitudinal, epidemiologic clinical-pathological study of memory, motor, and functional problems in older Catholic nuns, priests, and brothers aged 65 years and older from across the United States. Participants without known dementia agree to medical and psychological evaluation each year and brain donation after death. Since 1994, approximately 1,200 older persons have been enrolled and 580 are currently alive. Participants also have yearly blood draws which result in the storage of serum, plasma and cells. The Memory and Aging Project (MAP) is a longitudinal, epidemiologic clinical-pathologic study of dementia and other chronic diseases of aging. Older persons are recruited from about 40 continuous care retirement communities and senior subsidized housing facilities around the Chicago metropolitan area. Participants without known dementia agree to annual detailed clinical evaluation and donation of brain, spinal cord and muscle after death. MAP began in 1997 and over 1,600 older adults have enrolled. Approximately 1,000 participants are currently alive. Participants also have yearly blood draws which result in the storage of serum, plasma and cells. Clinical evaluation, self-report, and medication inspection are used to document medical conditions. The diagnostic process is the same for ROS and MAP. Briefly, a decision tree designed to mimic expert clinical judgment was implemented by computer to inform several clinical diagnoses, including dementia and AD. It combines data reduction techniques for the cognitive performance testing with a series of discrete clinical judgments made in series by a neuropsychologist and a clinician. Presumptive diagnoses of dementia and AD are calculated that conform to accepted clinical criteria. The clinician is asked to agree or disagree with the decisions. An algorithm uses these decisions to provide diagnoses of MCI and amnestic MCI. Persons with MCI are judged to have cognitive impairment by neuropsychologic testing without a diagnosis of dementia by the clinician. Persons without dementia or MCI are categorized as having no cognitive impairment (NCI). Subjects are also evaluated neurologically every year, and, at the time of death, a review of all ante-mortem data leads to a final clinical diagnosis for each participant: each individual receives a diagnosis of syndromic Alzheimer’s disease (AD), of mild cognitive impairment (MCI), or of no cognitive impairment (NCI). After the autopsy is concluded, a spectrum of neuropathologic diagnoses are obtained, such as a pathologic diagnosis of AD as defined using the modified NIA Reagan criteria based on a modified Bielschowsky silver stain to visualize amyloid plaques and neurofibrillary tangles. ## Related Datasets - [NG00029 – ROSMAP1 GWAS](https://dss.niagads.org/datasets/ng00029/) Two studies are included in this submission, the Memory and Aging Project (MAP) and the Religious Orders Study (ROS). The Religious Orders Study and the Rush Memory and Aging Project… [Learn more](https://dss.niagads.org/datasets/ng00029/) - [NG00067 – ADSP Umbrella](https://dss.niagads.org/datasets/ng00067/) This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common… [Learn more](https://dss.niagads.org/datasets/ng00067/) - [NG00095 – ROSMAP2 GWAS (CHOP)](https://dss.niagads.org/datasets/ng00095/) The Religious Orders Study (ROS) and Memory and Aging Project (MAP) are two community-based cohort studies. The Religious Orders Study and the Rush Memory and Aging Project are both cohort… [Learn more](https://dss.niagads.org/datasets/ng00095/) - [NG00116 – Resolving Mutations in Challenging Genomic Regions to Test Association with Disease Phenotypes](https://dss.niagads.org/datasets/ng00116/) Many regions of the human genome present challenges that prohibit scientists from discovering potential disease-causing mutations. We developed methods to characterize mutations in these regions to rescue mutations that are… [Learn more](https://dss.niagads.org/datasets/ng00116/) - [NG00118 – AMP-AD SV WGS and SV-xQTL](https://dss.niagads.org/datasets/ng00118/) Structural variants (SVs) were discovered in 1,760 donors by running a combination of seven different tools to capture the main classes of variation, including deletions (DEL), duplications (DUP), insertions (INS),… [Learn more](https://dss.niagads.org/datasets/ng00118/) - [NG00176-CNVs from ADSP WES data using CANOES software](https://dss.niagads.org/datasets/ng00176/) This dataset contains Copy Number Variation (CNV) calling from the Whole Exome Sequencing (WES) from multiple distinct Alzheimer Disease (AD) sequencing projects: both discovery and replication ADSP family dataset, ADSP… [Learn more](https://dss.niagads.org/datasets/ng00176/) - [NG00196- Genotyping short tandem repeats using the ADSP R4 cohort](https://dss.niagads.org/datasets/ng00196/) A two-step pipeline was used to first identify expanded short tandem repeats (STRs) in ADSP samples using ExpansionHunter Denovo and then genotype the identified STRs, along with additional polymorphic STRs… [Learn more](https://dss.niagads.org/datasets/ng00196/) ## Related Studies - [sa000011 - Accelerating Medicines Partnership- Alzheimer’s Disease (AMP-AD)](https://dss.niagads.org/studies/sa000011/) The Accelerating Medicines Partnership- Alzheimer’s Disease Target Discovery and Preclinical Validation (AMP-AD) has supported the generation of whole genome data from three studies: the MAYO RNAseq Study, the Mount Sinai… [Learn more](https://dss.niagads.org/studies/sa000011/) - [sa000003 - Alzheimer’s Disease Genetics Consortium (ADGC)](https://dss.niagads.org/studies/sa000003/) The ADGC is a large U.S. based consortium formed to collaboratively use the collective resources of the AD research community to resolve Alzheimer’s disease (AD) genetics. Working with the National… [Learn more](https://dss.niagads.org/studies/sa000003/) - [sa000001 - Alzheimer’s Disease Sequencing Project (ADSP)](https://dss.niagads.org/studies/sa000001/) Background An initiative in response to the National Alzheimer’s Project Act (NAPA) has been working towards new biological insights and cures for Alzheimer’s Disease (AD) since its introduction by NIH… [Learn more](https://dss.niagads.org/studies/sa000001/) - [sa000081 - Extremely Rare CNVs and Alzheimer’s Disease Risk: Analysis of ADSP WES Data](https://dss.niagads.org/studies/sa000081/) The purpose of this study is to find new Alzheimer related variants and genes, by combining exome data from healthy controls and Alzheimer patients from different studies. CNV calling was… [Learn more](https://dss.niagads.org/studies/sa000081/) - [sa000087 - Genotyping short tandem repeats using ADSP R4](https://dss.niagads.org/studies/sa000087/) Variation in tandem repeats (TRs), particularly large expansions of triplet repeats (e.g., polyCAG), is known to cause a number of late-onset neurological diseases. Due to their repetitive and degenerate nature,… [Learn more](https://dss.niagads.org/studies/sa000087/) - [sa000028 - Integrating whole-genome sequencing with multi-omic data reveals the impact of structural variants on gene regulation in the human brain – Vialle et al. 2022](https://dss.niagads.org/studies/sa000028/) Structural variants (SVs), defined as any genomic rearrangements of 50 or more bp, are an important source of genetic diversity and have been linked to many diseases. Here, we report… [Learn more](https://dss.niagads.org/studies/sa000028/) - [sa000042 - Resolving mutations in challenging genomic regions to test association with disease phenotypes](https://dss.niagads.org/studies/sa000042/) Many regions of the human genome present challenges that prohibit scientists from discovering potential disease causing mutations. We developed methods to characterize mutations in these regions to rescue mutations that… [Learn more](https://dss.niagads.org/studies/sa000042/) - [sa000077 - Rush Alzheimer’s Disease Center (RADC) Studies](https://dss.niagads.org/studies/sa000077/) The Rush Alzheimer's Disease Center (RADC) at Rush University Medical Center is a National Institute on Aging (NIA)-funded Alzheimer's Disease Research Center dedicated to advancing research on Alzheimer's disease, related… [Learn more](https://dss.niagads.org/studies/sa000077/) ## Related Sample Sets - [snd10000 - ADSP Discovery](https://dss.niagads.org/sample-sets/snd10000/) The initial phase of the ADSP research plan is called the Discovery Phase. Samples were selected from well-characterized study cohorts of individuals with or without an AD diagnosis and the… [Learn more](https://dss.niagads.org/sample-sets/snd10000/) - [snd10003 - ADGC AA WES](https://dss.niagads.org/sample-sets/snd10003/) ADGC African American samples were sequenced at University of Miami on the HiSeq3000 machine. 3226 samples were sequenced using the Agilent WES v6 target capture kit. BAM files from hg37… [Learn more](https://dss.niagads.org/sample-sets/snd10003/) - [snd10011 - AMP-AD WGS](https://dss.niagads.org/sample-sets/snd10011/) AMP-AD samples from the ROSMAP, MayoRNAseq, and Mount Sinai Brain Bank cohorts were whole-genome sequenced at New York Genome Center on the HiSeqX machine. FASTQ files were sent to GCAD… [Learn more](https://dss.niagads.org/sample-sets/snd10011/) - [snd10041 - AMP-AD WGS – SV Calls](https://dss.niagads.org/sample-sets/snd10041/) The AMP-AD WGS sampleset was sequenced on the Illumina HiSeqX sequencer (v2.5 chemistry) and made available from four aging and Alzheimer's disease cohorts: Religious Orders Study (ROS) and Memory and… [Learn more](https://dss.niagads.org/sample-sets/snd10041/) - [snd10074 - Camouflaged Variants](https://dss.niagads.org/sample-sets/snd10074/) Provided here are variant calls in VCF format for 14,526 samples derived from the ADSP whole-exome and whole-genome sequencing dataset (available via DSS: NG00067). [Learn more](https://dss.niagads.org/sample-sets/snd10074/) - [snd10134 - ROSMAP1 GWAS](https://dss.niagads.org/sample-sets/snd10134/) The ROSMAP1 sample set was genotyped using the Affymetrix 6.0 BeadChip which captures genotype data on 906,600 genomic SNPs. The standard Alzheimer's Disease Genetics Consortium (ADGC) quality control pipeline (Naj… [Learn more](https://dss.niagads.org/sample-sets/snd10134/) - [snd10135 - ROSMAP2 GWAS](https://dss.niagads.org/sample-sets/snd10135/) The ROSMAP2 sample set was genotyped at the Children’s Hospital of Philadelphia using the Illumina Infinium OmniExpress BeadChip which captures genotype data on 730,525 genomic SNPs. The standard Alzheimer's Disease… [Learn more](https://dss.niagads.org/sample-sets/snd10135/) - [snd10139 - CNV Calling from ADSP Whole-Exome Sequencing (WES) Data](https://dss.niagads.org/sample-sets/snd10139/) This dataset comprises CNV calls from Whole Exome Sequencing (WES) across multiple distinct Alzheimer’s Disease (AD) sequencing projects, including the discovery and replication ADSP family datasets, the ADSP case-control dataset,… [Learn more](https://dss.niagads.org/sample-sets/snd10139/) - [snd10147 - ADSP R4 Short Tandem Repeats (STRs)](https://dss.niagads.org/sample-sets/snd10147/) This dataset comprises short tandem repeat (STR) genotypes from 31,681 whole-genome sequencing (WGS) samples from the ADSP R4 data release. The STRs were genotyped using ExpansionHunter with a custom catalog… [Learn more](https://dss.niagads.org/sample-sets/snd10147/) ```