---
title: "Research in African-American Alzheimer’s Disease Initiative (REAAADI) "
id: "3850"
type: "cohort"
slug: "research-in-african-american-alzheimers-disease-initiative-reaaadi"
published_at: "2022-09-22T19:39:04+00:00"
modified_at: "2024-09-18T17:57:31+00:00"
url: "https://dss.niagads.org/cohorts/research-in-african-american-alzheimers-disease-initiative-reaaadi/"
markdown_url: "https://dss.niagads.org/cohorts/research-in-african-american-alzheimers-disease-initiative-reaaadi.md"
excerpt: "The Research in African-American Alzheimer’s Disease Initiative (REAAADI) is a NIH NIA study focused on identifying genetic factors for Alzheimer disease within the African-American population in order to detect new targets for drug development and improve accessibility to Alzheimer’s disease..."
taxonomy_cohort_categories:
  - "ADSP"
taxonomy_cohort_countries:
  - "United States of America"
---

## Description

The **Research in African-American Alzheimer’s Disease Initiative (REAAADI)** is a NIH NIA study focused on identifying genetic factors for Alzheimer disease within the African-American population in order to detect new targets for drug development and improve accessibility to Alzheimer’s disease education within the community. Participants were ascertained for multiple studies of AD/ADRD over the past 20 years, including healthy controls. Eligibility across studies was based on self-reported African American heritage. While participants were enrolled initially as part of larger studies of AD/ADRD, the first formal study focusing exclusively on African Americans began in in 2007 (Genetic Epidemiology of Alzheimer’s Disease in African Americans; AG028786). Ascertainment has continued since 2007 as part of multiple studies of AD/ADRD including the REAAADI Study (AG052410). Since 2007, participants have been ascertained via academic centers in North Carolina (Duke University, NC &T, Wake Forest University), Florida (University of Miami), New York (Columbia University), Ohio (Case Western University) and Tennessee (Vanderbilt University).

Participants were ascertained and evaluated through community centers, private memory clinics and adult day care centers. Some participants were evaluated in their homes. All participants greater than 60 years of age underwent a standard clinical evaluation consisting of a medical and family history interview, neuropsychological testing, behavioral and emotional assessments, and functional measures. Venous blood samples (or saliva samples when needed) were collected on all participants. All assessments were conducted in the preferred language of the participant or knowledgeable informant. Note that the assessment protocols have changed over the years, but a core group of clinical measures (including neuropsychological tests) are available for all participants.

## Related Datasets

- [NG00067 – ADSP Umbrella](https://dss.niagads.org/datasets/ng00067/) This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common… [Learn more](https://dss.niagads.org/datasets/ng00067/)

## Related Studies

- [sa000001 - Alzheimer’s Disease Sequencing Project (ADSP)](https://dss.niagads.org/studies/sa000001/) Background An initiative in response to the National Alzheimer’s Project Act (NAPA) has been working towards new biological insights and cures for Alzheimer’s Disease (AD) since its introduction by NIH… [Learn more](https://dss.niagads.org/studies/sa000001/)
- [sa000023 - Dissecting the Genomic Etiology of non-Mendelian Early-Onset Alzheimer Disease (EOAD) and Related Phenotypes](https://dss.niagads.org/studies/sa000023/) Background: Genomic studies of Alzheimer’s disease (AD) have primarily focused on non-Hispanic White (NHW) participants affected by the late-onset form of the disease (LOAD; onset age: >65), or the study… [Learn more](https://dss.niagads.org/studies/sa000023/)

## Related Sample Sets

- [snd10031 - ADSP-FUS2 WGS](https://dss.niagads.org/sample-sets/snd10031/) The ADSP-FUS is a National Institute on Aging (NIA) initiative focused on identifying genetic risk and protective variants for late-onset Alzheimer Disease (LOAD). A concern in AD genetic studies is… [Learn more](https://dss.niagads.org/sample-sets/snd10031/)
- [snd10095 - EOAD2 WGS](https://dss.niagads.org/sample-sets/snd10095/) 1,264 samples were sequenced at USUHS on the NovaSeq machine. FASTQ files were sent to GCAD for processing on the VCPA 1.1 pipeline. A total of 1,183 samples passed sequencing… [Learn more](https://dss.niagads.org/sample-sets/snd10095/)

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