---
title: "Seattle Alzheimer’s Disease Brain Cell Atlas (SEA-AD)"
id: "7320"
type: "cohort"
slug: "sea-ad"
published_at: "2024-11-26T14:28:32+00:00"
modified_at: "2025-05-22T12:58:27+00:00"
url: "https://dss.niagads.org/cohorts/sea-ad/"
markdown_url: "https://dss.niagads.org/cohorts/sea-ad.md"
excerpt: "Postmortem brain tissue and donor metadata were obtained via the UW BioRepository and Integrated Neuropathology (BRaIN) laboratory from participants in the Kaiser Permanente Washington Health Research Institute ACT Study and the University of Washington ADRC. The study cohort was selected..."
taxonomy_cohort_countries:
  - "United States of America"
---

Website:

[SEA-AD](http://SEA-AD.org)

## Description

Postmortem brain tissue and donor metadata were obtained via the UW BioRepository and Integrated Neuropathology (BRaIN) laboratory from participants in the Kaiser Permanente Washington Health Research Institute ACT Study and the University of Washington ADRC. The study cohort was selected based solely on donor brains undergoing precision rapid procedure (optimized tissue collection, slicing and freezing) during an inclusion time period at the start of the SEA-AD study, excluding those with a diagnosis of frontotemporal lobar degeneration, Down syndrome, amyotrophic lateral sclerosis or other confounding degenerative disorder (not including Lewy body disease, limbic-predominant TDP-43 encephalopathy or microvascular brain injury). The cohort was chosen in this manner to represent the full spectrum of AD neuropathology, with or without common comorbid age-related pathologies. No randomization was used in cohort selection. The experimental donor cohort contains 84 donors, 51 females and 33 males, aged 65–102 (mean 88). The 84 donors span the spectrum of AD pathology, from those without AD/dementia to those with dementia and high AD pathology. More information available at [SEA-AD.org](https://portal.brain-map.org/explore/seattle-alzheimers-disease)
.

## Related Datasets

- [NG00174-Whole Genome Sequencing (WGS) and SNP Array data for the SEA-AD Consortium Cohort](https://dss.niagads.org/datasets/ng00174/) This dataset contains whole genome sequencing (WGS) and genotyping SNP array data for the Seattle Alzheimer’s Disease Brain Cell Atlas (SEA-AD) consortium’s 84 donor cohort. Whole genome sequencing data includes… [Learn more](https://dss.niagads.org/datasets/ng00174/)

## Related Studies

- [sa000065 - The Seattle Alzheimer’s Disease Brain Cell Atlas (SEA-AD)](https://dss.niagads.org/studies/sa000065/) The Seattle Alzheimer’s Disease Brain Cell Atlas (SEA-AD) consortium strives to gain a deep molecular and cellular understanding of the early pathogenesis of Alzheimer’s disease by building a detailed map… [Learn more](https://dss.niagads.org/studies/sa000065/)

## Related Sample Sets

- [snd10108 - SEA-AD WGS](https://dss.niagads.org/sample-sets/snd10108/) Samples were sequenced by The American Genome Center and processed by the Genome Center for Alzheimer’s Disease (GCAD) at the University of Pennsylvania. This dataset includes (1) sequencing read alignments… [Learn more](https://dss.niagads.org/sample-sets/snd10108/)
- [snd10109 - SEA-AD Array data](https://dss.niagads.org/sample-sets/snd10109/) 80 samples from the SEA-AD cohort were genotyped by the Center for Applied Genomics at the Children's Hospital of Philadelphia using the Illumina Infinium Global Screening Array (GSA-24v3-0_A1) BeadChip which… [Learn more](https://dss.niagads.org/sample-sets/snd10109/)

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