---
title: "Sydney Brain Bank"
id: "8144"
type: "cohort"
slug: "sydney-brain-bank"
published_at: "2025-04-24T20:19:11+00:00"
modified_at: "2025-05-20T15:42:14+00:00"
url: "https://dss.niagads.org/cohorts/sydney-brain-bank/"
markdown_url: "https://dss.niagads.org/cohorts/sydney-brain-bank.md"
excerpt: "The Sydney Brain Bank (SBB) at Neuroscience Research Australia collects and characterizes human brain and spinal cord tissue from healthy aged donors and those with neurodegenerative conditions. Donors with motor neuron disease (MND) are recruited from Macquarie University and the..."
taxonomy_cohort_countries:
  - "Australia"
---

## Description

The Sydney Brain Bank (SBB) at Neuroscience Research Australia collects and characterizes human brain and spinal cord tissue from healthy aged donors and those with neurodegenerative conditions. Donors with motor neuron disease (MND) are recruited from Macquarie University and the Brain and Mind Centre at the University of Sydney.

## Related Datasets

- [NG00178 – Multi-brain region mRNA-seq of sporadic ALS patients with pTDP-43 pathological staging](https://dss.niagads.org/datasets/ng00178/) Post-mortem fresh-frozen brain tissue was obtained for 22 sporadic amyotrophic lateral sclerosis (ALS) cases and 11 neurologically healthy control participants from Sydney Brain Bank and the New South Wales Brain… [Learn more](https://dss.niagads.org/datasets/ng00178/)

## Related Studies

- [sa000068 - Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement](https://dss.niagads.org/studies/sa000068/) Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that primarily affects the motor neurons, causing progressive muscle weakness and paralysis. While research has focused on understanding pathological mechanisms in the… [Learn more](https://dss.niagads.org/studies/sa000068/)

## Related Sample Sets

- [snd10119 - ALS mRNA Sequencing](https://dss.niagads.org/sample-sets/snd10119/) This data includes 22 sporadic ALS patients with pTDP-43 pathological staging and 11 non-neurological controls. For each individual, five brain regions were examined (n=165 samples total): motor cortex (pTDP-43 inclusions… [Learn more](https://dss.niagads.org/sample-sets/snd10119/)

 ```