---
title: "UAB/HudsonAlpha Families with Neurodegenerative Diseases"
id: "8060"
type: "cohort"
slug: "uab-hudsonalpha-families-with-neurodegenerative-diseases"
published_at: "2025-03-31T16:48:26+00:00"
modified_at: "2025-04-01T13:37:01+00:00"
url: "https://dss.niagads.org/cohorts/uab-hudsonalpha-families-with-neurodegenerative-diseases/"
markdown_url: "https://dss.niagads.org/cohorts/uab-hudsonalpha-families-with-neurodegenerative-diseases.md"
excerpt: "We collected and analyzed genomic sequencing data from individuals with clinician-diagnosed early-onset or atypical dementia and, in many cases, their family members. One hundred total patients were described. Pathogenic variants, as well as established risk variants, were returned to patients...."
taxonomy_cohort_countries:
  - "United States of America"
---

## Description

We collected and analyzed genomic sequencing data from individuals with clinician-diagnosed early-onset or atypical dementia and, in many cases, their family members. One hundred total patients were described. Pathogenic variants, as well as established risk variants, were returned to patients. A polygenic risk score (PRS) was calculated for Alzheimer’s patients and compared to the scores of a late-onset Alzheimer’s cohort and a control set. Patients with early-onset Alzheimer’s had higher non-APOE PRSs than patients with late-onset Alzheimer’s, supporting the conclusion that both rare and common genetic variation associate with early-onset neurodegenerative disease risk.

## Related Datasets

- [NG00082 – UAB/HudsonAlpha Families with Neurodegenerative Diseases](https://dss.niagads.org/datasets/ng00082/) This study (UAB IRB study title: Evaluation of Genomic Variants in Patients with Neurologic Diseases) is to evaluate patients with early onset and/or atypical neurodegenerative diseases that are suspected to… [Learn more](https://dss.niagads.org/datasets/ng00082/)

## Related Studies

- [sa000067 - UAB/HudsonAlpha Families with Neurodegenerative Diseases](https://dss.niagads.org/studies/sa000067/) This study (UAB IRB study title: Evaluation of Genomic Variants in Patients with Neurologic Diseases) is to evaluate patients with early onset and/or atypical neurodegenerative diseases that are suspected to… [Learn more](https://dss.niagads.org/studies/sa000067/)

## Related Sample Sets

- [snd10115 - UAB/HudsonAlpha Families with Neurodegenerative Diseases – Set1 (2019)](https://dss.niagads.org/sample-sets/snd10115/) This study (UAB IRB study title: Evaluation of Genomic Variants in Patients with Neurologic Diseases) is to evaluate patients with early onset and/or atypical neurodegenerative diseases that are suspected to… [Learn more](https://dss.niagads.org/sample-sets/snd10115/)
- [snd10116 - UAB/HudsonAlpha Families with Neurodegenerative Diseases – Set2 (2024)](https://dss.niagads.org/sample-sets/snd10116/) This study (UAB IRB study title: Evaluation of Genomic Variants in Patients with Neurologic Diseases) is to evaluate patients with early onset and/or atypical neurodegenerative diseases that are suspected to… [Learn more](https://dss.niagads.org/sample-sets/snd10116/)

 ```