---
title: "University of Miami Brain Bank (MBB)"
id: "3836"
type: "cohort"
slug: "university-of-miami-brain-bank-mbb"
published_at: "2022-09-16T13:41:10+00:00"
modified_at: "2024-09-18T18:10:08+00:00"
url: "https://dss.niagads.org/cohorts/university-of-miami-brain-bank-mbb/"
markdown_url: "https://dss.niagads.org/cohorts/university-of-miami-brain-bank-mbb.md"
excerpt: "The University of Miami Brain Bank Cohort was ascertained through self-referred cases and controls to the University of Miami Brain Endowment Bank, a National Institutes of Health (NIH) NeuroBioBank, one of six designated brain and tissue biorepositories in the nation...."
taxonomy_cohort_categories:
  - "ADSP"
taxonomy_cohort_countries:
  - "United States of America"
---

Website:

[https://med.miami.edu/programs/brain-endowment-bank](https://med.miami.edu/programs/brain-endowment-bank)

## Description

The University of Miami Brain Bank Cohort was ascertained through self-referred cases and controls to the [University of Miami Brain Endowment Bank](https://med.miami.edu/programs/brain-endowment-bank)
, a National Institutes of Health (NIH) NeuroBioBank, one of six designated brain and tissue biorepositories in the nation. Medical records are available on all cases and controls, all of whom were tested before death for cognitive function.

Subjects included in the University of Miami Brain Endowment Bank cohort include individuals who were donors to the University of Miami Brain Endowment Bank from 1986 to 2020. Donors were either individuals with history of cognitive impairment and neuropathological changes consistent with Alzheimer disease, or cognitively unaffected individuals without such neuropathological changes. Participants were recruited from community organizations, organ/tissue donation program registries, or self-referral. This is an autopsy-based study designed to analyze post-mortem brain tissue. Medical records are also obtained as available to help correlate brain behavior relationships.

## Related Datasets

- [NG00067 – ADSP Umbrella](https://dss.niagads.org/datasets/ng00067/) This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common… [Learn more](https://dss.niagads.org/datasets/ng00067/)
- [NG00196- Genotyping short tandem repeats using the ADSP R4 cohort](https://dss.niagads.org/datasets/ng00196/) A two-step pipeline was used to first identify expanded short tandem repeats (STRs) in ADSP samples using ExpansionHunter Denovo and then genotype the identified STRs, along with additional polymorphic STRs… [Learn more](https://dss.niagads.org/datasets/ng00196/)

## Related Studies

- [sa000001 - Alzheimer’s Disease Sequencing Project (ADSP)](https://dss.niagads.org/studies/sa000001/) Background An initiative in response to the National Alzheimer’s Project Act (NAPA) has been working towards new biological insights and cures for Alzheimer’s Disease (AD) since its introduction by NIH… [Learn more](https://dss.niagads.org/studies/sa000001/)
- [sa000087 - Genotyping short tandem repeats using ADSP R4](https://dss.niagads.org/studies/sa000087/) Variation in tandem repeats (TRs), particularly large expansions of triplet repeats (e.g., polyCAG), is known to cause a number of late-onset neurological diseases. Due to their repetitive and degenerate nature,… [Learn more](https://dss.niagads.org/studies/sa000087/)

## Related Sample Sets

- [snd10031 - ADSP-FUS2 WGS](https://dss.niagads.org/sample-sets/snd10031/) The ADSP-FUS is a National Institute on Aging (NIA) initiative focused on identifying genetic risk and protective variants for late-onset Alzheimer Disease (LOAD). A concern in AD genetic studies is… [Learn more](https://dss.niagads.org/sample-sets/snd10031/)
- [snd10147 - ADSP R4 Short Tandem Repeats (STRs)](https://dss.niagads.org/sample-sets/snd10147/) This dataset comprises short tandem repeat (STR) genotypes from 31,681 whole-genome sequencing (WGS) samples from the ADSP R4 data release. The STRs were genotyped using ExpansionHunter with a custom catalog… [Learn more](https://dss.niagads.org/sample-sets/snd10147/)

 ```