---
title: "University of Pittsburgh (PITT)"
id: "2384"
type: "cohort"
slug: "university-of-pittsburgh-pitt"
published_at: "2021-02-24T00:32:59+00:00"
modified_at: "2024-09-18T18:13:06+00:00"
url: "https://dss.niagads.org/cohorts/university-of-pittsburgh-pitt/"
markdown_url: "https://dss.niagads.org/cohorts/university-of-pittsburgh-pitt.md"
excerpt: "Study participants were enrolled at the University of Pittsburgh Alzheimer’s Disease Research Center (ADRC), all of whom met the National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer’s Disease and Related Disorders Association clinical criteria for probable AD. Each participant..."
taxonomy_cohort_categories:
  - "ADSP"
taxonomy_cohort_countries:
  - "United States of America"
---

## Description

Study participants were enrolled at the University of Pittsburgh Alzheimer’s Disease Research Center (ADRC), all of whom met the National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer’s Disease and Related Disorders Association clinical criteria for probable AD. Each participant had undergone an extensive neuropsychiatric evaluation, which has been described in detail previously. Briefly, this involved a physical examination, neurological examination, semistructured psychiatric interview, and neuropsychological assessment. All patient records were reviewed at a multidisciplinary clinical consensus conference for assignment of a diagnosis. The inclusion/exclusion criteria have been published previously, but it is important to note that one of the criteria was that all the patients had to have a reliable caregiver that could provide detailed information about the patients’ clinical symptoms and their activities of daily living (ADLs). The caregiver was interviewed in person once a year and by phone every 6 months. In case of loss of a caregiver, the data were censored as the last date that reliable information was received from the caregiver.

Lopez OL, Becker JT, Saxton J, Sweet RA, Klunk W, DeKosky ST. Alteration of a clinically meaningful outcome in the natural history of Alzheimer’s disease by cholinesterase inhibition. J Am Geriatr Soc. 2005 Jan;53(1):83-7. doi: 10.1111/j.1532-5415.2005.53015.x. PMID: [15667381](https://pubmed.ncbi.nlm.nih.gov/15667381/)
.

## Related Datasets

- [NG00067 – ADSP Umbrella](https://dss.niagads.org/datasets/ng00067/) This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common… [Learn more](https://dss.niagads.org/datasets/ng00067/)

## Related Studies

- [sa000059 - Genetic Architecture of Alzheimer’s disease and Related Proteinopathies](https://dss.niagads.org/studies/sa000059/) This is a collaborative study between investigators from the University of Pittsburgh (Pitt) and Washington University (WashU) to delineate the genetic architecture of Alzheimer’s disease (AD) and AD-related proteinopathies. The… [Learn more](https://dss.niagads.org/studies/sa000059/)
- [sa000012 - University of Pittsburgh- Kamboh](https://dss.niagads.org/studies/sa000012/) The project goal is to perform whole-genome sequencing (WGS) on Alzheimer’s disease (AD) cases to identify both common and uncommon variants associated with AD-related phenotypes (e.g., disease progression, survival time).… [Learn more](https://dss.niagads.org/studies/sa000012/)

## Related Sample Sets

- [snd10012 - UPITT Kamboh 1 WGS](https://dss.niagads.org/sample-sets/snd10012/) UPITT samples were whole-genome sequenced at New York Genome Center on the HiSeqX machine. BAM files from hg37 build were sent to GCAD for processing on the VCPA1.1 pipeline. 209… [Learn more](https://dss.niagads.org/sample-sets/snd10012/)
- [snd10091 - Pitt-Kamboh-2 WGS](https://dss.niagads.org/sample-sets/snd10091/) 209 samples of the PITT cohort underwent whole-genome sequencing at NYGC using the Illumina HiSeqX platform. The resulting BAM files were sent to GCAD for processing via the VCPA1.1 pipeline.… [Learn more](https://dss.niagads.org/sample-sets/snd10091/)
- [snd10100 - Amyloid-Pitt WGS](https://dss.niagads.org/sample-sets/snd10100/) A total of 1,195 samples were sequenced at MGI and NYGC on the NovaSeq6000 platform. 498 bam and 697 cram files were sent to GCAD for processing. A total of… [Learn more](https://dss.niagads.org/sample-sets/snd10100/)
- [snd10147 - ADSP R4 Short Tandem Repeats (STRs)](https://dss.niagads.org/sample-sets/snd10147/) This dataset comprises short tandem repeat (STR) genotypes from 31,681 whole-genome sequencing (WGS) samples from the ADSP R4 data release. The STRs were genotyped using ExpansionHunter with a custom catalog… [Learn more](https://dss.niagads.org/sample-sets/snd10147/)

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