--- title: "University of Toronto (TOR)" id: "1522" type: "cohort" slug: "university-of-toronto" published_at: "2020-02-19T15:18:55+00:00" modified_at: "2024-09-18T18:13:35+00:00" url: "https://dss.niagads.org/cohorts/university-of-toronto/" markdown_url: "https://dss.niagads.org/cohorts/university-of-toronto.md" excerpt: "This study was carried out under the direction of Dr. Peter St George-Hyslop and Dr Rogaeva at the Tanz Centre for Research in Neurodegenerative Diseases (CRND), University of Toronto. In order to explore the potential role of hereditary factors, a..." taxonomy_cohort_categories: - "ADSP" taxonomy_cohort_countries: - "Canada" --- Website: [http://www.tanz.med.utoronto.ca/familial-alzheimer%E2%80%99s-disease-registry](http://www.tanz.med.utoronto.ca/familial-alzheimer%E2%80%99s-disease-registry) ## Description This study was carried out under the direction of Dr. Peter St George-Hyslop and Dr Rogaeva at the Tanz Centre for Research in Neurodegenerative Diseases (CRND), University of Toronto. In order to explore the potential role of hereditary factors, a registry at the Tanz CRND with a coordinator was established for families in which two or more individuals have the suspected diagnosis of Alzheimer’s Disease or other forms of dementia. Eligibility requirements were disseminated through the CRND website. Individuals who contacted the Registry received a family history questionnaire in the mail. For sufficiently informative families, researchers sought consent to obtain blood samples from available family members required for genetic research. Collaborating neurologists and genetic counselors also referred families that fit the requirements. All collected individuals were given numeric IDs to protect their privacy. Families were eligible if: two or more members, living or decease, were affected by Alzheimer’s Disease, Parkinson’s Disease, amyotrophic lateral sclerosis, frontal temporal dementia or Creutzfeldt-Jacob Disease. Families were ineligible if: there were fewer than 2 affected members or family history was unavailable to document. ## Related Datasets - [NG00024 – ADC3 – Alzheimer’s Disease Center Dataset 3](https://dss.niagads.org/datasets/ng00024/) This GWAS dataset, ADC3, is the third set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing… [Learn more](https://dss.niagads.org/datasets/ng00024/) - [NG00067 – ADSP Umbrella](https://dss.niagads.org/datasets/ng00067/) This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common… [Learn more](https://dss.niagads.org/datasets/ng00067/) - [NG00116 – Resolving Mutations in Challenging Genomic Regions to Test Association with Disease Phenotypes](https://dss.niagads.org/datasets/ng00116/) Many regions of the human genome present challenges that prohibit scientists from discovering potential disease-causing mutations. We developed methods to characterize mutations in these regions to rescue mutations that are… [Learn more](https://dss.niagads.org/datasets/ng00116/) - [NG00176-CNVs from ADSP WES data using CANOES software](https://dss.niagads.org/datasets/ng00176/) This dataset contains Copy Number Variation (CNV) calling from the Whole Exome Sequencing (WES) from multiple distinct Alzheimer Disease (AD) sequencing projects: both discovery and replication ADSP family dataset, ADSP… [Learn more](https://dss.niagads.org/datasets/ng00176/) ## Related Studies - [sa000003 - Alzheimer’s Disease Genetics Consortium (ADGC)](https://dss.niagads.org/studies/sa000003/) The ADGC is a large U.S. based consortium formed to collaboratively use the collective resources of the AD research community to resolve Alzheimer’s disease (AD) genetics. Working with the National… [Learn more](https://dss.niagads.org/studies/sa000003/) - [sa000001 - Alzheimer’s Disease Sequencing Project (ADSP)](https://dss.niagads.org/studies/sa000001/) Background An initiative in response to the National Alzheimer’s Project Act (NAPA) has been working towards new biological insights and cures for Alzheimer’s Disease (AD) since its introduction by NIH… [Learn more](https://dss.niagads.org/studies/sa000001/) - [sa000081 - Extremely Rare CNVs and Alzheimer’s Disease Risk: Analysis of ADSP WES Data](https://dss.niagads.org/studies/sa000081/) The purpose of this study is to find new Alzheimer related variants and genes, by combining exome data from healthy controls and Alzheimer patients from different studies. CNV calling was… [Learn more](https://dss.niagads.org/studies/sa000081/) - [sa000042 - Resolving mutations in challenging genomic regions to test association with disease phenotypes](https://dss.niagads.org/studies/sa000042/) Many regions of the human genome present challenges that prohibit scientists from discovering potential disease causing mutations. We developed methods to characterize mutations in these regions to rescue mutations that… [Learn more](https://dss.niagads.org/studies/sa000042/) ## Related Sample Sets - [snd10000 - ADSP Discovery](https://dss.niagads.org/sample-sets/snd10000/) The initial phase of the ADSP research plan is called the Discovery Phase. Samples were selected from well-characterized study cohorts of individuals with or without an AD diagnosis and the… [Learn more](https://dss.niagads.org/sample-sets/snd10000/) - [snd10060 - ADGC ADC Round 3](https://dss.niagads.org/sample-sets/snd10060/) The ADC3 sample set was genotyped by the Center for Applied Genomics at the Children's Hospital of Philadelphia using the Illumina Human OmniExpress (HumanOmniExpress-12v1_A) BeadChip which captures genotype data on… [Learn more](https://dss.niagads.org/sample-sets/snd10060/) - [snd10074 - Camouflaged Variants](https://dss.niagads.org/sample-sets/snd10074/) Provided here are variant calls in VCF format for 14,526 samples derived from the ADSP whole-exome and whole-genome sequencing dataset (available via DSS: NG00067). [Learn more](https://dss.niagads.org/sample-sets/snd10074/) - [snd10139 - CNV Calling from ADSP Whole-Exome Sequencing (WES) Data](https://dss.niagads.org/sample-sets/snd10139/) This dataset comprises CNV calls from Whole Exome Sequencing (WES) across multiple distinct Alzheimer’s Disease (AD) sequencing projects, including the discovery and replication ADSP family datasets, the ADSP case-control dataset,… [Learn more](https://dss.niagads.org/sample-sets/snd10139/) ```