--- title: "Washington Heights and Inwood Community Aging project (WHICAP)" id: "965" type: "cohort" slug: "washington-heights-and-inwood-community-aging-project-whicap" published_at: "2019-06-17T20:22:10+00:00" modified_at: "2024-11-13T14:38:33+00:00" url: "https://dss.niagads.org/cohorts/washington-heights-and-inwood-community-aging-project-whicap/" markdown_url: "https://dss.niagads.org/cohorts/washington-heights-and-inwood-community-aging-project-whicap.md" excerpt: "Unrelated Nondemented (initially), 65 years of age or older including non‐Hispanic whites (32%), African Americans (28%), and Caribbean Hispanics from the Dominican Republic (44%). Assessments include: medical evaluation, cognitive testing, MRI, PET scan and biomarkers studies. For more information about..." taxonomy_cohort_categories: - "ADSP" taxonomy_cohort_countries: - "United States of America" --- Website: [http://www.columbianeuroresearch.org/taub/res-normal.html](http://www.columbianeuroresearch.org/taub/res-normal.html) ## Description Unrelated Nondemented (initially), 65 years of age or older including non‐Hispanic whites (32%), African Americans (28%), and Caribbean Hispanics from the Dominican Republic (44%). Assessments include: medical evaluation, cognitive testing, MRI, PET scan and biomarkers studies. For more information about this cohort, see the [WHICAP study](https://dss.niagads.org/studies/sa000007/) . ## Related Datasets - [NG00067 – ADSP Umbrella](https://dss.niagads.org/datasets/ng00067/) This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common… [Learn more](https://dss.niagads.org/datasets/ng00067/) - [NG00093 – WHICAP GWAS (CHOP)](https://dss.niagads.org/datasets/ng00093/) The Washington Heights-Inwood Community Aging Project (WHICAP) is a community-based longitudinal study of aging and dementia among elderly, urban-dwelling residents. Beginning enrolment in 1989, WHICAP has followed more than 5,900… [Learn more](https://dss.niagads.org/datasets/ng00093/) - [NG00116 – Resolving Mutations in Challenging Genomic Regions to Test Association with Disease Phenotypes](https://dss.niagads.org/datasets/ng00116/) Many regions of the human genome present challenges that prohibit scientists from discovering potential disease-causing mutations. We developed methods to characterize mutations in these regions to rescue mutations that are… [Learn more](https://dss.niagads.org/datasets/ng00116/) - [NG00176-CNVs from ADSP WES data using CANOES software](https://dss.niagads.org/datasets/ng00176/) This dataset contains Copy Number Variation (CNV) calling from the Whole Exome Sequencing (WES) from multiple distinct Alzheimer Disease (AD) sequencing projects: both discovery and replication ADSP family dataset, ADSP… [Learn more](https://dss.niagads.org/datasets/ng00176/) ## Related Studies - [sa000001 - Alzheimer’s Disease Sequencing Project (ADSP)](https://dss.niagads.org/studies/sa000001/) Background An initiative in response to the National Alzheimer’s Project Act (NAPA) has been working towards new biological insights and cures for Alzheimer’s Disease (AD) since its introduction by NIH… [Learn more](https://dss.niagads.org/studies/sa000001/) - [sa000081 - Extremely Rare CNVs and Alzheimer’s Disease Risk: Analysis of ADSP WES Data](https://dss.niagads.org/studies/sa000081/) The purpose of this study is to find new Alzheimer related variants and genes, by combining exome data from healthy controls and Alzheimer patients from different studies. CNV calling was… [Learn more](https://dss.niagads.org/studies/sa000081/) - [sa000062 - Genetic Studies of Alzheimer’s Disease in Caribbean Hispanics (EFIGA)](https://dss.niagads.org/studies/sa000062/) The Genetic Studies of Alzheimer’s Disease in Caribbean Hispanics (EFIGA) is the largest collection of Caribbean Hispanic multiplex AD families recruited and longitudinally assessed worldwide. At this stage we are… [Learn more](https://dss.niagads.org/studies/sa000062/) - [sa000042 - Resolving mutations in challenging genomic regions to test association with disease phenotypes](https://dss.niagads.org/studies/sa000042/) Many regions of the human genome present challenges that prohibit scientists from discovering potential disease causing mutations. We developed methods to characterize mutations in these regions to rescue mutations that… [Learn more](https://dss.niagads.org/studies/sa000042/) - [sa000007 - Washington Heights and Inwood Community Aging project (WHICAP)](https://dss.niagads.org/studies/sa000007/) Since inception of the study in 1992, over 6,000 participants have enrolled in the Washington Heights and Inwood Community Aging project (WHICAP). The cohort participants were nondemented initially, 65 years… [Learn more](https://dss.niagads.org/studies/sa000007/) ## Related Sample Sets - [snd10000 - ADSP Discovery](https://dss.niagads.org/sample-sets/snd10000/) The initial phase of the ADSP research plan is called the Discovery Phase. Samples were selected from well-characterized study cohorts of individuals with or without an AD diagnosis and the… [Learn more](https://dss.niagads.org/sample-sets/snd10000/) - [snd10001 - ADSP Extension](https://dss.niagads.org/sample-sets/snd10001/) The ADSP Discovery Family-Based Extension Study: To further assess the genomes in multiply affected families, under funding provided by NHGRI, an additional 427 samples were whole genome sequenced. This included… [Learn more](https://dss.niagads.org/sample-sets/snd10001/) - [snd10007 - WHICAP WES](https://dss.niagads.org/sample-sets/snd10007/) The WHICAP WES study consists of a multi-ethnic cohort of 4,100 individuals followed over several years. Participants were community-living Medicare recipients 65 years and older recruited from northern Manhattan to… [Learn more](https://dss.niagads.org/sample-sets/snd10007/) - [snd10074 - Camouflaged Variants](https://dss.niagads.org/sample-sets/snd10074/) Provided here are variant calls in VCF format for 14,526 samples derived from the ADSP whole-exome and whole-genome sequencing dataset (available via DSS: NG00067). [Learn more](https://dss.niagads.org/sample-sets/snd10074/) - [snd10104 - EFIGA1 WGS](https://dss.niagads.org/sample-sets/snd10104/) A total of 1,396 EFIGA cohort samples were sequenced at NYGC and USUHS using the Illumina HiSeqX platform. The BAM files were sent to GCAD for processing through the VCPA1.1… [Learn more](https://dss.niagads.org/sample-sets/snd10104/) - [snd10106 - WHICAP1 WGS](https://dss.niagads.org/sample-sets/snd10106/) A total of 237 WHICAP cohort samples were sequenced at NYGC and USUHS using the Illumina HiSeqX platform. The BAM files were sent to GCAD for processing through the VCPA1.1… [Learn more](https://dss.niagads.org/sample-sets/snd10106/) - [snd10132 - WHICAP GWAS](https://dss.niagads.org/sample-sets/snd10132/) The WHICAP sample set was genotyped at the Children’s Hospital of Philadelphia using the Illumina Infinium OmniExpress BeadChip which captures genotype data on 730,525 genomic SNPs. The standard Alzheimer's Disease… [Learn more](https://dss.niagads.org/sample-sets/snd10132/) - [snd10139 - CNV Calling from ADSP Whole-Exome Sequencing (WES) Data](https://dss.niagads.org/sample-sets/snd10139/) This dataset comprises CNV calls from Whole Exome Sequencing (WES) across multiple distinct Alzheimer’s Disease (AD) sequencing projects, including the discovery and replication ADSP family datasets, the ADSP case-control dataset,… [Learn more](https://dss.niagads.org/sample-sets/snd10139/) ```