---
title: "Wisconsin Registry for Alzheimer’s Prevention (WRAP)"
id: "3847"
type: "cohort"
slug: "wisconsin-registry-for-alzheimers-prevention-wrap"
published_at: "2022-09-15T18:02:21+00:00"
modified_at: "2024-09-18T18:16:02+00:00"
url: "https://dss.niagads.org/cohorts/wisconsin-registry-for-alzheimers-prevention-wrap/"
markdown_url: "https://dss.niagads.org/cohorts/wisconsin-registry-for-alzheimers-prevention-wrap.md"
excerpt: "The Wisconsin Registry for Alzheimer’s Prevention (WRAP) is an ongoing longitudinal observational cohort study of individuals age 40-65 at baseline who do not have dementia. Since 2001, WRAP has enrolled more than 1,700 individuals, 73% of whom had a parental..."
taxonomy_cohort_categories:
  - "ADSP"
taxonomy_cohort_countries:
  - "United States of America"
---

Website:

[https://wrap.wisc.edu/](https://wrap.wisc.edu/)

## Description

The [Wisconsin Registry for Alzheimer’s Prevention (WRAP)](https://wrap.wisc.edu/)
 is an ongoing longitudinal observational cohort study of individuals age 40-65 at baseline who do not have dementia. Since 2001, WRAP has enrolled more than 1,700 individuals, 73% of whom had a parental history of probable Alzheimer’s disease (AD) dementia. Participants return for a second visit approximately 4 years after baseline, and subsequent visits occur every 2 years. At each visit, a cognitive test battery is administered, self-reported medical and lifestyle histories (e.g., diet, physical and cognitive activity, sleep, and mood) are assessed via questionnaire, and blood is drawn for laboratory tests, metabolomics, and genomics. A subset of participants have also undergone molecular imaging, structural imaging, and cerebrospinal fluid collection for biomarker measurement.

GeneRations Of WRAP (GROW) is an ancillary study to the Wisconsin Registry for Alzheimer’s Prevention (WRAP), a longitudinal cohort study enriched for individuals with a parental history of probable Alzheimer’s disease (AD) dementia. GROW is a family study that recruited extended family members of existing WRAP participants. Genomic data from family members with probable AD dementia were collected via banked brains or saliva. Individuals free of dementia and within the WRAP eligibility age of 40-65 were enrolled in WRAP. At each study visit, a cognitive test battery is administered, self-reported medical and lifestyle histories (e.g., diet, physical and cognitive activity, sleep, and mood) are assessed via questionnaire, and blood is drawn for laboratory tests, metabolomics, and genomics. A subset of participants have also undergone molecular imaging, structural imaging, and cerebrospinal fluid collection for biomarker measurement.

## Related Datasets

- [NG00067 – ADSP Umbrella](https://dss.niagads.org/datasets/ng00067/) This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common… [Learn more](https://dss.niagads.org/datasets/ng00067/)
- [NG00196- Genotyping short tandem repeats using the ADSP R4 cohort](https://dss.niagads.org/datasets/ng00196/) A two-step pipeline was used to first identify expanded short tandem repeats (STRs) in ADSP samples using ExpansionHunter Denovo and then genotype the identified STRs, along with additional polymorphic STRs… [Learn more](https://dss.niagads.org/datasets/ng00196/)

## Related Studies

- [sa000001 - Alzheimer’s Disease Sequencing Project (ADSP)](https://dss.niagads.org/studies/sa000001/) Background An initiative in response to the National Alzheimer’s Project Act (NAPA) has been working towards new biological insights and cures for Alzheimer’s Disease (AD) since its introduction by NIH… [Learn more](https://dss.niagads.org/studies/sa000001/)
- [sa000087 - Genotyping short tandem repeats using ADSP R4](https://dss.niagads.org/studies/sa000087/) Variation in tandem repeats (TRs), particularly large expansions of triplet repeats (e.g., polyCAG), is known to cause a number of late-onset neurological diseases. Due to their repetitive and degenerate nature,… [Learn more](https://dss.niagads.org/studies/sa000087/)

## Related Sample Sets

- [snd10031 - ADSP-FUS2 WGS](https://dss.niagads.org/sample-sets/snd10031/) The ADSP-FUS is a National Institute on Aging (NIA) initiative focused on identifying genetic risk and protective variants for late-onset Alzheimer Disease (LOAD). A concern in AD genetic studies is… [Learn more](https://dss.niagads.org/sample-sets/snd10031/)
- [snd10147 - ADSP R4 Short Tandem Repeats (STRs)](https://dss.niagads.org/sample-sets/snd10147/) This dataset comprises short tandem repeat (STR) genotypes from 31,681 whole-genome sequencing (WGS) samples from the ADSP R4 data release. The STRs were genotyped using ExpansionHunter with a custom catalog… [Learn more](https://dss.niagads.org/sample-sets/snd10147/)

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