---
title: "NG00020 – NIA AD-FBS GWAS"
id: "7618"
type: "dataset"
slug: "ng00020"
published_at: "2025-01-21T19:21:43+00:00"
modified_at: "2026-07-31T20:16:59+00:00"
url: "https://dss.niagads.org/datasets/ng00020/"
markdown_url: "https://dss.niagads.org/datasets/ng00020.md"
excerpt: "To access this data, please log into DSS and submit an application.Within the application, add this dataset (accession NG00020) in the “Choose a Dataset” section.Once approved, you will be able to log in and access the data within the DARM..."
taxonomy_dataset_categories:
  - "AD"
  - "Controlled Access"
  - "Data Type"
  - "Disease"
  - "Genotyping SNP Array"
  - "Illumina Human610-Quad"
  - "Open and Controlled Access Data"
  - "Platform"
---

## Overview

To access this data, please log into DSS and submit an application.  
Within the application, add this dataset (accession NG00020) in the “Choose a Dataset” section.  
Once approved, you will be able to log in and access the data within the DARM portal.

This dataset was originally published on the NIAGADS archive site and was moved to DSS on 07/30/2026.

#### Description

The goal of the National Institute of Aging Alzheimer’s Disease Family Based Study, NIA AD-FBS (formerly National Institute on Aging Genetics Initiative for Late-Onset Alzheimer’s Disease, NIA-LOAD) is to identify and recruit families with two or more siblings with the late-onset form of Alzheimer’s disease and a cohort of unrelated, non-demented controls similar in age and ethnic background, and to make the samples, the clinical and genotyping data and preliminary analyses available to qualified investigators world-wide.

Genotyping done by the Center for Inherited Disease Research (CIDR) was performed using the Illumina Infinium II assay protocol with hybridization to Illumina Human 610Quadv1_B Beadchips. When first deposited in 2012, this genotyping represented the largest collection of families ever assembled with Alzheimer’s disease combining the NIA-LOAD Genetics Initiative Multiplex Family Study, the National Cell Repository for Alzheimer’s Disease (NCRAD) with additional controls from the NIA Alzheimer’s Disease Research Centers (ADRC).

A subset of unrelated cases and controls which contains PLINK genotype files that have undergone ADGC quality control procedures, covariates formatted by ADGC to be used with the genotype data, and imputation files (.bgen format) generated using the TOPMED-r2 reference panel is available for request in dataset NG00032.

#### Sample Summary per Data Type

| Sample Set | Accession | Data Type | Number of Samples |
| --- | --- | --- | --- |
| NIA AD-FBS GWAS | snd10144 | Genotyping SNP Array | 5,221 |

#### Available Filesets

| Name | Accession | Latest Release | Description |
| --- | --- | --- | --- |
| NIA AD-FBS GWAS: Genotype and phenotype files | fsa000174 | NG00020.v1 | Genotype and phenotype files |

View the [File Manifest](https://st1.niagads.org/portal/download-public/NG00020.v1/fm)
 for a full list of files released in this dataset.

## Participant Information

For a breakdown of the study population characteristics, navigate to the individual sample sets below.

| Sample Set | Accession Number | Number of Participants | Number of Samples |
| --- | --- | --- | --- |
| NIA AD-FBS GWAS | snd10144 | 5,221 | 5,221 |

## Related Studies

- [sa000063 - National Institute of Aging Alzheimer’s Disease Family Based Study (NIA AD-FBS)](https://dss.niagads.org/studies/sa000063/) The National Institute on Aging Alzheimer's Disease Family Based Study (NIA AD-FBS) is the largest collection of multiplex AD families recruited and longitudinally assessed worldwide. Since 2003, the central goal… [Learn more](https://dss.niagads.org/studies/sa000063/)

## Cohorts

| Cohort | Number of Participants | Number of Samples |
| --- | --- | --- |
| National Centralized Repository for Alzheimer’s Disease and Related Dementias Family (NCRAD Family) | 680 | 680 |
| National Institute of Aging Alzheimer’s Disease Family Based Study (NIA AD-FBS) | 4,292 | 4,292 |
| NIA Alzheimer's Disease Research Centers (ADRC) | 176 | 176 |
| University of Washington Families (RAS) | 73 | 73 |

## Consent Levels

| Consent Level | Number of Participants | Number of Samples |
| --- | --- | --- |
| DS-ADRDAGE-IRB-PUB | 176 | 176 |
| DS-NEURO-IRB-PUB | 73 | 73 |
| GRU-IRB-PUB | 4,972 | 4,972 |

Visit the [Data Use Limitations page](/documentation/policies-and-guidelines/data-use-limitations/)
 for definitions of the consent levels above.

## Acknowledgement

### Acknowledgment statement for any data distributed by NIAGADS:

Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer's Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.

Use the study-specific acknowledgement statements below (as applicable):

### For investigators using any data from this dataset:

Please cite/reference the use of NIAGADS data by including the accession [NG00020](https://archive.niagads.org/datasets/NG00020)
.

### For investigators using National Institute of Aging Alzheimer’s Disease Family Based Study (NIA AD-FBS) (sa000063) data:

The NIA-AD FBS study supported the collection of samples used in this study through National Institute on Aging (NIA) grants U24AG056270,U24AG026395, R01AG041797 and U24AG056270. We thank contributors, including the Alzheimer’s disease Centers who collected samples used in this study, as well as patients and their families, whose help and participation made this work possible.

## Publications

- Lee JH. **Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: implication of additional loci.***Archives of neurology. 2008 Nov.*[PubMed link](https://pubmed.ncbi.nlm.nih.gov/19001172/)

### Total number of participants: 9,388

SexRaceEthnicityDiagnosisAPOE

Female5,20255.4 %

Male4,18644.6 %

| American Indian/Alaska Native | 9 |
| --- | --- |
| Asian | 7 |
| Black or African American | 273 |
| White | 4,449 |
| Other | 284 |
| NA | 4,366 |

- 2214 (0.1%)
- 23333 (3.5%)
- 24153 (1.6%)
- 332,024 (21.6%)
- 342,152 (22.9%)
- 44544 (5.8%)
- NA4,168 (44.4%)

| AD |  |  |
| --- | --- | --- |
| Control | 2,558 | 27.2% |
| Case | 2,475 | 26.4% |
| Unknown | 4,355 | 46.4% |

Not Hispanic or Latino

4,594

48.9%

Hispanic or Latino

597

6.4%

Not Applicable/Not Available

4,197

44.7%