---
title: "NG00059 – Aging, Dementia, and TBI Study: RNASeq Dataset"
id: "9351"
type: "dataset"
slug: "ng00059"
published_at: "2026-09-11T13:45:29+00:00"
modified_at: "2026-09-15T15:02:39+00:00"
url: "https://dss.niagads.org/datasets/ng00059/"
markdown_url: "https://dss.niagads.org/datasets/ng00059.md"
excerpt: "To access this data, please log into DSS and submit an application.Within the application, add this dataset (accession NG00059) in the “Choose a Dataset” section.Once approved, you will be able to log in and access the data within the DARM..."
taxonomy_dataset_categories:
  - "Controlled Access"
  - "Data Type"
  - "Dementia"
  - "Disease"
  - "Illumina HiSeq 2500"
  - "Open and Controlled Access Data"
  - "Platform"
  - "Short-Read RNA Sequencing"
---

## Overview

To access this data, please log into DSS and submit an application.  
Within the application, add this dataset (accession NG00059) in the “Choose a Dataset” section.  
Once approved, you will be able to log in and access the data within the DARM portal.

This dataset was originally published on the NIAGADS archive site and was moved to DSS on 09/11/26.

#### Description

The Aging, Dementia and Traumatic Brain Injury Study is a detailed neuropathologic, molecular and transcriptomic characterization of brains of control and TBI exposure cases from a unique aged population-based cohort from the Adult Changes in Thought (ACT) study. This study was developed by a consortium consisting of the University of Washington, Kaiser Permanente Washington Health Research Institute, and the Allen Institute for Brain Science, and was supported by the Paul G. Allen Family Foundation.

This freely available resource ([http://aging.brain-map.org/](http://aging.brain-map.org/)
) presents a systematic and extensive data set of study participant metadata, quantitative histology and protein measurements of neuropathology, and RNA sequencing (RNA-seq) analysis of hippocampus and neocortex. In total, 377 samples collected from cortical grey (parietal and temporal) and white matter (parietal) and hippocampus from a total of 107 brains are presented in this resource.

Phenotypes are available for download through the Aging, Dementia, and TBI Study website here, [http://aging.brain-map.org/download/index](http://aging.brain-map.org/download/index)
.

#### Sample Summary per Data Type

| Sample Set | Accession | Data Type | Number of Samples |
| --- | --- | --- | --- |
| Aging, Dementia, and TBI Study: RNASeq Dataset | snd10148 | Short-Read RNA Sequencing | 377 |

#### Available Filesets

| Name | Accession | Latest Release | Description |
| --- | --- | --- | --- |
| AllenAgingDementiaTBI: RNASeq Data | fsa000182 | NG00059.v1 | RNASeq Data |

View the [File Manifest](https://st1.niagads.org/portal/download-public/NG00059.v1/fm)
 for a full list of files released in this dataset.

## Participant Information

For a breakdown of the study population characteristics, navigate to the individual sample sets below.

| Sample Set | Accession Number | Number of Participants | Number of Samples |
| --- | --- | --- | --- |
| Aging, Dementia, and TBI Study: RNASeq Dataset | snd10148 | 107 | 377 |

## Related Studies

- [sa000088 - Aging, Dementia, and TBI Study](https://dss.niagads.org/studies/sa000088/) The Aging, Dementia and Traumatic Brain Injury Study is a detailed neuropathologic, molecular and transcriptomic characterization of brains of control and TBI exposure cases from a unique aged population-based cohort… [Learn more](https://dss.niagads.org/studies/sa000088/)

## Cohorts

| Cohort | Number of Participants | Number of Samples |
| --- | --- | --- |
| Adult Changes in Thought (ACT) | 107 | 377 |

## Consent Levels

| Consent Level | Number of Participants | Number of Samples |
| --- | --- | --- |
| DS-AGEADLT-IRB-PUB | 107 | 377 |

Visit the [Data Use Limitations page](/documentation/policies-and-guidelines/data-use-limitations/)
 for definitions of the consent levels above.

## Acknowledgement

### Acknowledgment statement for any data distributed by NIAGADS:

Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer's Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.

Use the study-specific acknowledgement statements below (as applicable):

### For investigators using any data from this dataset:

Please cite/reference the use of NIAGADS data by including the accession [NG00059](https://archive.niagads.org/datasets/NG00059)
.

### For investigators using Aging, Dementia, and TBI Study (sa000088) data:

We thank the Allen Institute for Brain Science founders, P.G. Allen and J. Allen, for their vision, encouragement, and support. The study was supported by the Paul G. Allen Family Foundation (PIs: Richard Ellenbogen and C. Dirk Keene, University of Washington; PI: Eric Larson, Kaiser Permanente Washington Health Research Institute; and PI: Ed Lein, Allen Institute for Brain Science).

## Publications

- Miller JA. **Neuropathological and transcriptomic characteristics of the aged brain.***eLife. 2017 Nov 9.*[PubMed link](https://pubmed.ncbi.nlm.nih.gov/29120328/)

### Total number of participants: 107

SexRaceEthnicityDiagnosisAPOE

Female4441.1 %

Male6358.9 %

| White | 105 |
| --- | --- |
| NA | 2 |

- NA107 (100.0%)

| Dementia |  |  |
| --- | --- | --- |
| Control | 56 | 52.3% |
| Case | 50 | 46.7% |
| Other | 1 | 0.9% |

Not Hispanic or Latino

107

100.0%