---
title: "NG00182 – GARD GWAS Summary Statistics – Kang et al., 2024"
id: "8411"
type: "dataset"
slug: "ng00182"
published_at: "2025-08-12T17:27:19+00:00"
modified_at: "2026-03-19T15:12:00+00:00"
url: "https://dss.niagads.org/datasets/ng00182/"
markdown_url: "https://dss.niagads.org/datasets/ng00182.md"
excerpt: "All data provided in this dataset are open access and are available publicly in the “Open Access Dataset” tab."
taxonomy_dataset_categories:
  - "Data Type"
  - "Illumina NovaSeq 6000"
  - "Imputation"
  - "Open Access"
  - "Open and Controlled Access Data"
  - "Summary Statistics"
  - "TOPMed r2"
---

## Overview

All data provided in this dataset are open access and are available publicly in the “Open Access Dataset” tab.

#### Description

This dataset contains GWAS summary statistics derived from single-variant association tests for WGS data (minor allele count ≥ 10, call rate > 0.95) from 3,540 Koreans aged 60 years or older (1,583 AD cases, 1,957 controls). SNP array data (minor allele frequency > 0.01, call rate > 0.95) was derived from 2,978 Japanese aged 65 years or older (1,336 AD cases, 1,642 controls). There are five Korean WGS GWAS result datasets (the total Korean sample, APOE ε4 carriers, APOE ε4 non-carriers, males, and females) and five meta-analyzed GWAS result datasets (the total Korean and Japanese sample, APOE ε4 carriers, APOE ε4 non-carriers, males, and females). We do not provide GWAS results derived from Japanese datasets only.

#### Available Filesets

| Name | Accession | Latest Release | Description |
| --- | --- | --- | --- |
| GARD GWAS Summary Statistics (open access) | fsa000147 | NG00182.v1 | Summary Statistics |

View the [File Manifest](https://st1.niagads.org/portal/download-public/NG00182.v1/fm)
 for a full list of files released in this dataset.

## Related Studies

- [sa000073 - Whole-genome sequencing study in Koreans identifies novel loci for Alzheimer’s disease – Kang et al., 2024](https://dss.niagads.org/studies/sa000073/) South Korea, one of the most rapidly aging populations in the world, has a high incidence and prevalence of Alzheimer's disease (AD) among individuals aged 65 years or older. Like… [Learn more](https://dss.niagads.org/studies/sa000073/)

## Acknowledgement

### Acknowledgment statement for any data distributed by NIAGADS:

Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer's Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.

Use the study-specific acknowledgement statements below (as applicable):

### For investigators using any data from this dataset:

Please cite/reference the use of NIAGADS data by including the accession [NG00182](https://archive.niagads.org/datasets/NG00182)
.

### For investigators using Whole-genome sequencing study in Koreans identifies novel loci for Alzheimer’s disease – Kang et al., 2024 (sa000073) data:

GWAS data for the JGSCAD cohort were obtained from the Alzheimer’s Disease Genetics Consortium, which is funded by National Institute on Aging (NIA) grant U01-AG032984. Gene expression data were provided by the Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA. Data collection was supported through funding by NIA grants P30AG10161 (ROS), R01AG15819 (ROSMAP; genomics and RNAseq), R01AG17917 (MAP), R01AG30146, R01AG36042 (5hC methylation, ATACseq), RC2AG036547 (H3K9A), R01AG36836 (RNAseq), R01AG48015 (monocyte RNAseq), RF1AG57473 (single-nucleus RNAseq), U01AG32984 (genomic and whole-exome sequencing), U01AG46152 (ROSMAP AMP-AD, targeted proteomics), U01AG46161 (TMT proteomics), U01AG61356 (whole-genome sequencing, targeted proteomics, ROSMAP AMP-AD), the Illinois Department of Public Health (ROSMAP), and the Translational Genomics Research Institute (genomic). Additional phenotypic data can be requested at www.radc.rush.edu. This study was supported by NIA grants U01-AG062602, R01-AG048927, U01-AG032984, U01-AG058654, U54-AG052427, U19-AG068753, U01-AG081230, P30-AG072978. This study was supported by the KBRI Basic Research Program through the Korea Brain Research Institute, funded by the Ministry of Science and ICT of the Korean government (24-BR-03-05).

## Publications

- Kang M. **Whole-genome sequencing study in Koreans identifies novel loci for Alzheimer's disease.***Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024 Dec.*[PubMed link](https://pubmed.ncbi.nlm.nih.gov/39428694/)

### Total number of participants: 0