---
title: "NG00191 – GWAS for CSF AD Aβ and tau in 18,948 individuals of European ancestry"
id: "9404"
type: "dataset"
slug: "ng00191"
published_at: "2026-09-24T19:43:39+00:00"
modified_at: "2026-09-25T13:50:10+00:00"
url: "https://dss.niagads.org/datasets/ng00191/"
markdown_url: "https://dss.niagads.org/datasets/ng00191.md"
excerpt: "The p-value only files are available in the “Open Access Dataset” tab.To access the full data, please log into DSS and submit an application.Within the application, add this dataset (accession NG00191) in the “Choose a Dataset” section.Once approved, you will..."
taxonomy_dataset_categories:
  - "AD"
  - "Controlled Access"
  - "Data Type"
  - "Disease"
  - "Open Access"
  - "Open and Controlled Access Data"
  - "Summary Statistics"
---

## Overview

The p-value only files are available in the “Open Access Dataset” tab.  
To access the full data, please log into DSS and submit an application.  
Within the application, add this dataset (accession NG00191) in the “Choose a Dataset” section.  
Once approved, you will be able to log in and access the data within the DARM portal.

#### Description

We performed a GWAS meta-analysis including 18,948 individuals of European ancestry. This is the largest study to date for the three biomarkers encompassing 30 different studies. Biomarker levels from 6,785 participants across 22 studies were combined into a single dataset using a z-score based data standardization (mean 0 and variance 1 within each cohort) and analyzed at Washington University in St. Louis Charles F. and Joanne Knight Alzheimer Disease Research Center (Knight ADRC). The summary statistics from this dataset were then meta-analyzed with summary statistics from eight cohorts : European Alzheimer’s and Dementia Biobank (EADB, N=7,516), The European Prevention of Alzheimer’s Dementia (EPAD, N=1,370), Ace Alzheimer Center Barcelona (ACE, N=1,302), European Medical Information Framework for Alzheimer’s Disease (EMIF-AD, N=670), MISSION-AD (N=462, Eisai), Janssen cohorts 1 and 2 (Janssen, N=457) and Alzheimer’s and Families cohort (ALFA+ study, N=386).This dataset consists of METAL summary statistics (GRCh38) for the three biomarkers obtained at the end of meta-analysis.

#### Available Filesets

| Name | Accession | Latest Release | Description |
| --- | --- | --- | --- |
| CSF GWAS Meta: Full Summary Statistics (application needed) | fsa000183 | NG00191.v1 | Full Summary Statistics |
| CSF GWAS Meta: P-values only (open access) | fsa000184 | NG00191.v1 | P-values only |

View the [File Manifest](https://st1.niagads.org/portal/download-public/NG00191.v1/fm)
 for a full list of files released in this dataset.

## Related Studies

- [sa000089 - GWAS meta-analysis of CSF Alzheimer’s biomarkers reveals novel loci regulating lipids, brain volume and autophagy](https://dss.niagads.org/studies/sa000089/) Cerebrospinal fluid amyloid beta 42, total tau, and phosphorylated tau 181 are well accepted markers of Alzheimer’s disease. These biomarkers better reflect disease pathogenesis compared to clinical diagnosis. Identifying genes/loci… [Learn more](https://dss.niagads.org/studies/sa000089/)

## Acknowledgement

### Acknowledgment statement for any data distributed by NIAGADS:

Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer's Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.

Use the study-specific acknowledgement statements below (as applicable):

### For investigators using any data from this dataset:

Please cite/reference the use of NIAGADS data by including the accession [NG00191](https://archive.niagads.org/datasets/NG00191)
.

### For investigators using GWAS meta-analysis of CSF Alzheimer’s biomarkers reveals novel loci regulating lipids, brain volume and autophagy (sa000089) data:

This work was supported by grants from the National Institutes of Health (R01-AG064614 (CC), U01-AG084514 (CC), P01-NS131131 (CC), R01-AG078964(CC), R01-AG058501 (CC), R01-AG071706 (CC), P30-AG066444 (CC), R01-AG064877 (CC), and the Cure Alzheimer's Fund.

The recruitment and clinical characterization of research participants at Washington University were supported by NIH P30AG066444 (DMH), P01AG03991 (JCM), and P01AG026276 (JCM).

This work was supported by access to equipment made possible by the Hope Center for Neurological Disorders, the NeuroGenomics and Informatics Center (NGI: https://neurogenomics.wustl.edu/) and the Departments of Neurology and Psychiatry at Washington University School of Medicine.

## Publications

- Timsina J. **GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy.***Nature communications. 2026 Apr 21.*[PubMed link](https://pubmed.ncbi.nlm.nih.gov/42014397/)

### Total number of participants: 0