---
title: "ADNI-WGS-1"
id: "461"
type: "sample_set"
slug: "snd10002"
published_at: "2020-02-19T18:24:56+00:00"
modified_at: "2023-12-14T22:22:52+00:00"
url: "https://dss.niagads.org/sample-sets/snd10002/"
markdown_url: "https://dss.niagads.org/sample-sets/snd10002.md"
excerpt: "Whole Genome Sequencing Data In July 2012, the Brin-Wojcicki Foundation and the Alzheimer’s Association donated funds to support whole genome sequencing (WGS) of 818 ADNI participants (at the time: 128 with AD, 415 with MCI, 267 controls and 8 of..."
---

## Description

### Whole Genome Sequencing Data

In July 2012, the Brin-Wojcicki Foundation and the Alzheimer’s Association donated funds to support whole genome sequencing (WGS) of 818 ADNI participants (at the time: 128 with AD, 415 with MCI, 267 controls and 8 of uncertain diagnosis). Samples were sent to Illumina, where non-CLIA WGS, as well as Illumina Omni 2.5M genome-wide association study (GWAS) single nucleotide polymorphism (SNP) arrays, were performed on each sample and completed in Spring 2013.

The samples were sequenced on the Illumina HiSeq 2000 platform with 100bp paired-end reads.

*Information obtained from the [ADNI website](http://adni.loni.usc.edu/about/)
 on August 28, 2018.*

## Cohorts

- [Alzheimer’s Disease Neuroimaging Initiative (ADNI)](https://dss.niagads.org/cohorts/alzheimers-disease-neuroimaging-initiative-adni/)

## Sex

### Total number of samples: 808

Female36244.8 %

Male44655.2 %

## Race

### Total number of samples: 808

| American Indian/Alaska Native | 2 |
| --- | --- |
| Asian | 10 |
| Native Hawaiian or Other Pacific Islander | 2 |
| Black or African American | 28 |
| White | 756 |
| Other | 10 |

## Ethnicity

### Total number of samples: 808

Not Hispanic or Latino

784

97.0%

Hispanic or Latino

19

2.4%

Not Applicable/Not Available

5

0.6%

## Diagnosis

### Total number of samples: 808

| AD |  |  |
| --- | --- | --- |
| Control | 249 | 30.8% |
| Case | 238 | 29.5% |
| Other | 321 | 39.7% |

## APOE

### Total number of samples: 808

- 221 (0.1%)
- 2370 (8.7%)
- 2415 (1.9%)
- 33405 (50.1%)
- 34260 (32.2%)
- 4457 (7.1%)