---
title: "FASe Families WES"
id: "1620"
type: "sample_set"
slug: "snd10004"
published_at: "2020-02-19T18:49:16+00:00"
modified_at: "2023-12-14T22:23:51+00:00"
url: "https://dss.niagads.org/sample-sets/snd10004/"
markdown_url: "https://dss.niagads.org/sample-sets/snd10004.md"
excerpt: "FASe Family samples were sequenced at Genentech, MGI and Otogenetics on the HiSeq2000 machine. 715 samples were sequenced using the Agilent WES v5 capture region, 164 samples were using the Nimblegen VCRome sequencing w/Custom Spike-In Baits and 225 samples were..."
---

## Description

FASe Family samples were sequenced at Genentech, MGI and Otogenetics on the HiSeq2000 machine. 715 samples were sequenced using the Agilent WES v5 capture region, 164 samples were using the Nimblegen VCRome sequencing w/Custom Spike-In Baits and 225 samples were using the Roche Nimblegen’s VCRome v2.1 target capture kit. BAM files from hg37 build were sent to GCAD for processing on the VCPA1.1 pipeline. 1041 passed sequencing metrics and quality control.

## Cohorts

- [National Centralized Repository for Alzheimer’s Disease and Related Dementias Family (NCRAD Family)](https://dss.niagads.org/cohorts/national-centralized-repository-for-alzheimers-disease-and-related-dementias-family-ncrad-family/)
- [National Institute of Aging Alzheimer’s Disease Family Based Study (NIA AD-FBS)](https://dss.niagads.org/cohorts/national-institute-on-aging-late-onset-of-alzheimers-disease-family-nia-load/)
- [University of Washington Families (RAS)](https://dss.niagads.org/cohorts/university-of-washington-families-ras/)

## Sex

### Total number of samples: 1,100

Female67060.9 %

Male43039.1 %

## Race

### Total number of samples: 1,100

| American Indian/Alaska Native | 4 |
| --- | --- |
| White | 1,096 |

## Ethnicity

### Total number of samples: 1,100

Not Hispanic or Latino

1,090

99.1%

Hispanic or Latino

10

0.9%

## Diagnosis

### Total number of samples: 1,100

| AD |  |  |
| --- | --- | --- |
| Control | 254 | 23.1% |
| Case | 747 | 67.9% |
| Other | 55 | 5.0% |
| Unknown | 44 | 4.0% |

## APOE

### Total number of samples: 1,100

- 222 (0.2%)
- 2328 (2.5%)
- 2422 (2.0%)
- 33333 (30.3%)
- 34555 (50.5%)
- 44160 (14.5%)