---
title: "Harari Methylation"
id: "3433"
type: "sample_set"
slug: "snd10025"
published_at: "2022-02-04T16:48:38+00:00"
modified_at: "2022-02-04T16:48:38+00:00"
url: "https://dss.niagads.org/sample-sets/snd10025/"
markdown_url: "https://dss.niagads.org/sample-sets/snd10025.md"
excerpt: "Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder with many biological processes, and molecular changes. The etiology of AD is complex and not specific to a single genetic factor. Epigenetic changes could help explain the missing heritability not capture in..."
---

## Description

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder with many biological processes, and molecular changes. The etiology of AD is complex and not specific to a single genetic factor. Epigenetic changes could help explain the missing heritability not capture in GWAS chips and determine functional variants in genome-wide significant loci. DNA methylation data from 431 parietal lobe of AD and neuropath-free controls was generated from the Knight-ADRC. The Illumina Infinium MethylationEPIC interrogates the methylation over 850,000 CpG and non-CpG sites, open chromatin, enhancers, DNase hypersensitive sites and promoters.

## Cohorts

- [Knight Alzheimer’s Disease Research Center (KGAD)](https://dss.niagads.org/cohorts/knight-alzheimers-disease-research-center-kgad/)

## Sex

### Total number of samples: 431

Female25659.4 %

Male17440.4 %

Sex not reported: 1

## Race

### Total number of samples: 431

| American Indian/Alaska Native | 1 |
| --- | --- |
| Black or African American | 17 |
| White | 413 |

## Ethnicity

### Total number of samples: 431

Not Hispanic or Latino

89

20.6%

Hispanic or Latino

1

0.2%

Not Applicable/Not Available

341

79.1%

## Diagnosis

### Total number of samples: 431

| Alzheimer's Disease and Related Dementias (ADRD) |  |  |
| --- | --- | --- |
| Control | 35 | 8.1% |
| Case | 383 | 88.9% |
| Other | 12 | 2.8% |

| NA |  |  |
| --- | --- | --- |
| Unknown | 1 | 0.2% |

## APOE

### Total number of samples: 431

- 2322 (5.1%)
- 2420 (4.6%)
- 33181 (42.0%)
- 34167 (38.7%)
- 4437 (8.6%)
- 4 (0.9%)