---
title: "KnightADRC GWAS"
id: "4188"
type: "sample_set"
slug: "snd10036"
published_at: "2022-11-17T16:15:11+00:00"
modified_at: "2025-05-16T18:22:18+00:00"
url: "https://dss.niagads.org/sample-sets/snd10036/"
markdown_url: "https://dss.niagads.org/sample-sets/snd10036.md"
excerpt: "The data being submitted includes GWAS for 4,496 participants from the Knight-ADRC MAP study. Participants include 1,958 AD cases (58% Females, 56% APOE4+, average age 73), 755 ADRD cases (FTD, DLB, PD, PSP, ALS, other: 51% Females, 38% APOE4+, average..."
---

## Description

The data being submitted includes GWAS for 4,496 participants from the Knight-ADRC MAP study. Participants include 1,958 AD cases (58% Females, 56% APOE4+, average age 73), 755 ADRD cases (FTD, DLB, PD, PSP, ALS, other: 51% Females, 38% APOE4+, average age 73), and 1,783 cognitively healthy controls (60% Females, 31% APOE4+, average age 74). Approximately 86% of the samples are self-defined as “White” and 12.5% are self-defined as “Black or African-American”. Genotyping was generated through 10 different genotyping arrays (Infinium CoreExome-24, Infinium Neuro Consortium Array, Infinium Global Screening Array-24, Infinium OmniExpress-24, Illumina Human660W-Quad, Human610-Quad, Illumina Omni1-Quad, Affy UK Biobank Axiom, Infinium OmniExpressExome-8, and Illumina Human1M-Duo). All genotype samples have polygenic risk scores indicating the risk for Alzheimer’s disease (AD), Parkinson’s disease (PD), Frontotemporal dementia (FTD) risk along with CSF Aβ42, phosphorylated tau, and total tau.

## Cohorts

- [Knight Alzheimer’s Disease Research Center (KGAD)](https://dss.niagads.org/cohorts/knight-alzheimers-disease-research-center-kgad/)

## Sex

### Total number of samples: 4,496

Female2,59757.8 %

Male1,88641.9 %

Sex not reported: 13

## Race

### Total number of samples: 4,496

| American Indian/Alaska Native | 6 |
| --- | --- |
| Asian | 11 |
| Native Hawaiian or Other Pacific Islander | 1 |
| Black or African American | 566 |
| White | 3,861 |
| NA | 51 |

## Ethnicity

### Total number of samples: 4,496

Not Hispanic or Latino

2,574

57.3%

Hispanic or Latino

27

0.6%

Not Applicable/Not Available

1,895

42.1%

## Diagnosis

### Total number of samples: 4,496

| AD |  |  |
| --- | --- | --- |
| Control | 1,783 | 39.7% |
| Case | 1,958 | 43.5% |

| Dementia Lewy Bodies (DLB) |  |  |
| --- | --- | --- |
| Case | 59 | 1.3% |

| Fronto Temporal Dementia (FTD) |  |  |
| --- | --- | --- |
| Case | 130 | 2.9% |

| Parkinson disease (PD) |  |  |
| --- | --- | --- |
| Case | 20 | 0.4% |

| PSP |  |  |
| --- | --- | --- |
| Case | 18 | 0.4% |

| Other |  |  |
| --- | --- | --- |
| Case | 1 | 0.0% |
| Other | 527 | 11.7% |

## APOE

### Total number of samples: 4,496

- 2219 (0.4%)
- 23366 (8.1%)
- 24136 (3.0%)
- 331,971 (43.8%)
- 341,512 (33.6%)
- 44281 (6.3%)
- NA211 (4.7%)