---
title: "ADGC ADC Round 8"
id: "5919"
type: "sample_set"
slug: "snd10065"
published_at: "2024-02-07T19:22:07+00:00"
modified_at: "2024-02-07T19:22:08+00:00"
url: "https://dss.niagads.org/sample-sets/snd10065/"
markdown_url: "https://dss.niagads.org/sample-sets/snd10065.md"
excerpt: "The ADC8 sample set was genotyped using the Illumina Human OmniExpressExome BeadChip, which captures genotype data on 964,193 genomic SNPs. This includes a selected subset of 273,246 functional exonic variants that heavily overlap with the variants genotyped on Illumina’s previous..."
---

## Description

The ADC8 sample set was genotyped using the Illumina Human OmniExpressExome BeadChip, which captures genotype data on 964,193 genomic SNPs. This includes a selected subset of 273,246 functional exonic variants that heavily overlap with the variants genotyped on Illumina’s previous exome chip array. As many exome chip association and genome-wide association analyses are performed separately, we have extracted the exonic variants into separate PLINK-formatted files from the remaining ~690,000 variants in order to facilitate ease of analysis, and simplifying combining files with overlapping marker sets (samples genotyped only on GWAS arrays or only on exome chip arrays). Quality control was performed separately for the genomic and exonic datasets.

## Cohorts

- [NIA Alzheimer's Disease Research Centers (ADRC)](https://dss.niagads.org/cohorts/nia-alzheimers-disease-research-centers-adrc/)

## Sex

### Total number of samples: 2,359

Female1,51264.1 %

Male84635.9 %

Sex not reported: 1

## Race

### Total number of samples: 2,359

| Black or African American | 812 |
| --- | --- |
| White | 1,430 |
| Other | 116 |
| NA | 1 |

## Ethnicity

### Total number of samples: 2,359

Not Hispanic or Latino

1,912

81.1%

Hispanic or Latino

446

18.9%

Not Applicable/Not Available

1

0.0%

## Diagnosis

### Total number of samples: 2,359

| AD |  |  |
| --- | --- | --- |
| Control | 958 | 40.6% |
| Case | 839 | 35.6% |
| Unknown | 562 | 23.8% |

## APOE

### Total number of samples: 2,359

- 2210 (0.4%)
- 23217 (9.2%)
- 2497 (4.1%)
- 331,097 (46.5%)
- 34769 (32.6%)
- 44167 (7.1%)
- NA2 (0.1%)