---
title: "ALS mRNA Sequencing"
id: "8151"
type: "sample_set"
slug: "snd10119"
published_at: "2025-04-24T21:52:17+00:00"
modified_at: "2025-08-28T19:40:43+00:00"
url: "https://dss.niagads.org/sample-sets/snd10119/"
markdown_url: "https://dss.niagads.org/sample-sets/snd10119.md"
excerpt: "This data includes 22 sporadic ALS patients with pTDP-43 pathological staging and 11 non-neurological controls. For each individual, five brain regions were examined (n=165 samples total): motor cortex (pTDP-43 inclusions always present), prefrontal cortex and hippocampus (pTDP-43 inclusions sometimes present),..."
---

## Description

This data includes 22 sporadic ALS patients with pTDP-43 pathological staging and 11 non-neurological controls. For each individual, five brain regions were examined (n=165 samples total): motor cortex (pTDP-43 inclusions always present), prefrontal cortex and hippocampus (pTDP-43 inclusions sometimes present), and occipital cortex and cerebellum (pTDP-43 inclusions rarely present). Samples had an average read depth of 27 million 151bp paired-end reads (range: 20 – 45 million).

## Cohorts

- [New South Wales Brain Tissue Resource Centre](https://dss.niagads.org/cohorts/new-south-wales-brain-tissue-resource-centre/)
- [Sydney Brain Bank](https://dss.niagads.org/cohorts/sydney-brain-bank/)

## Sex

### Total number of samples: 165

Female7042.4 %

Male9557.6 %

## Race

### Total number of samples: 165

| White | 165 |
| --- | --- |

## Diagnosis

### Total number of samples: 165

| Amyotrophic Lateral Sclerosis (ALS) |  |  |
| --- | --- | --- |
| Control | 55 | 33.3% |
| Case | 110 | 66.7% |