---
title: "ROSMAP2 GWAS"
id: "9138"
type: "sample_set"
slug: "snd10135"
published_at: "2026-07-08T19:38:16+00:00"
modified_at: "2026-07-08T19:38:16+00:00"
url: "https://dss.niagads.org/sample-sets/snd10135/"
markdown_url: "https://dss.niagads.org/sample-sets/snd10135.md"
excerpt: "The ROSMAP2 sample set was genotyped at the Children’s Hospital of Philadelphia using the Illumina Infinium OmniExpress BeadChip which captures genotype data on 730,525 genomic SNPs. The standard Alzheimer’s Disease Genetics Consortium (ADGC) quality control pipeline (Naj et al. 2011)..."
---

## Description

The ROSMAP2 sample set was genotyped at the Children’s Hospital of Philadelphia using the Illumina Infinium OmniExpressBeadChip which captures genotype data on 730,525 genomic SNPs. The standard Alzheimer’s Disease Genetics Consortium (ADGC) quality control pipeline ([Naj et al. 2011](https://pubmed.ncbi.nlm.nih.gov/21460841/)
) was applied to this GWAS dataset. The final QC’d dataset is on GRCh38.

## Cohorts

- [Religious Orders Study/Memory and Aging Project (ROSMAP)](https://dss.niagads.org/cohorts/religious-orders-study-memory-and-aging-project-rosmap/)

## Sex

### Total number of samples: 533

Female21139.6 %

Male6512.2 %

Sex not reported: 257

## Race

### Total number of samples: 533

| White | 276 |
| --- | --- |
| NA | 257 |

## Ethnicity

### Total number of samples: 533

Not Hispanic or Latino

276

51.8%

Not Applicable/Not Available

257

48.2%

## Diagnosis

### Total number of samples: 533

| AD |  |  |
| --- | --- | --- |
| Control | 217 | 40.7% |
| Case | 59 | 11.1% |
| Unknown | 257 | 48.2% |

## APOE

### Total number of samples: 533

- 2318 (3.4%)
- 242 (0.4%)
- 3371 (13.3%)
- 3429 (5.4%)
- 442 (0.4%)
- NA411 (77.1%)