---
title: "Genetic Component of the Mapping the Human Connectome During Typical Aging (HCP-A) & Vulnerability and Resiliency in the Aging Adult Brain Connectome (AABC)"
id: "8714"
type: "sample_set"
slug: "snd10137"
published_at: "2026-02-06T19:42:44+00:00"
modified_at: "2026-02-09T15:18:17+00:00"
url: "https://dss.niagads.org/sample-sets/snd10137/"
markdown_url: "https://dss.niagads.org/sample-sets/snd10137.md"
excerpt: "The AABC (formerly HCP-A) is working to uncover how brain structure and function changes as a normal part of aging by collecting and analyzing multimodal neuroimaging, behavioral, and genetic data. The specific goal of this analyses is to identify genetic..."
---

## Description

The AABC (formerly HCP-A) is working to uncover how brain structure and function changes as a normal part of aging by collecting and analyzing multimodal neuroimaging, behavioral, and genetic data. The specific goal of this analyses is to identify genetic variants associated with healthy aging.

Genotyping for these participants were generated through Illumina GSA v3.0 genotyping array and imputed using the TOPMed Reference Panel. Samples were QC’d using PLINK and retained using standard pipelines, resulting in 1,024 samples and 164,824,889 total variants (10,147,726 passing a 1% MAF threshold with a 98% call rate).

No phenotypes are provided with this dataset. Request phenotype data, APOE, and Polygenic Risk Scores via BALSA: [https://balsa.wustl.edu/project?project=AABC](https://balsa.wustl.edu/project?project=AABC)

## Cohorts

- [Mapping the Human Connectome During Typical Aging (HCP-A) & Vulnerability and Resiliency in the Aging Adult Brain Connectome (AABC)](https://dss.niagads.org/cohorts/mapping-the-human-connectome-during-typical-aging-hcp-a-vulnerability-and-resiliency-in-the-aging-adult-brain-connectome-aabc/)

## Sex

### Total number of samples: 1,024

Female55854.5 %

Male45844.7 %

Sex not reported: 8

## Race

### Total number of samples: 1,024

| American Indian/Alaska Native | 2 |
| --- | --- |
| Asian | 71 |
| Native Hawaiian or Other Pacific Islander | 2 |
| Black or African American | 133 |
| White | 747 |
| Other | 40 |
| NA | 29 |

## Ethnicity

### Total number of samples: 1,024

Not Hispanic or Latino

888

86.7%

Hispanic or Latino

126

12.3%

Not Applicable/Not Available

10

1.0%

## Diagnosis

### Total number of samples: 1,024

| Healthy Aging |  |  |
| --- | --- | --- |
| Unknown | 1,024 | 100.0% |

## APOE

### Total number of samples: 1,024

- 2210 (1.0%)
- 23122 (11.9%)
- 2428 (2.7%)
- 33649 (63.4%)
- 34190 (18.6%)
- 4424 (2.3%)
- NA1 (0.1%)