--- title: "ADSP R4 Short Tandem Repeats (STRs)" id: "9385" type: "sample_set" slug: "snd10147" published_at: "2026-09-29T19:12:49+00:00" modified_at: "2026-09-29T19:12:49+00:00" url: "https://dss.niagads.org/sample-sets/snd10147/" markdown_url: "https://dss.niagads.org/sample-sets/snd10147.md" excerpt: "This dataset comprises short tandem repeat (STR) genotypes from 31,681 whole-genome sequencing (WGS) samples from the ADSP R4 data release. The STRs were genotyped using ExpansionHunter with a custom catalog of approximately 165,000 STRs selected based on their levels of..." --- ## Description This dataset comprises short tandem repeat (STR) genotypes from 31,681 whole-genome sequencing (WGS) samples from the ADSP R4 data release. The STRs were genotyped using ExpansionHunter with a custom catalog of approximately 165,000 STRs selected based on their levels of polymorphism and/or propensity for rare expansions. The dataset also includes sample crosswalk files. ## Cohorts - [Adult Changes in Thought (ACT)](https://dss.niagads.org/cohorts/adult-changes-in-thought-act/) - [Alzheimer’s Disease Neuroimaging Initiative (ADNI)](https://dss.niagads.org/cohorts/alzheimers-disease-neuroimaging-initiative-adni/) - [Amish Protective Variant Study](https://dss.niagads.org/cohorts/amish-protective-variant-study/) - [Case Western Reserve University (CWRU) Autopsy](https://dss.niagads.org/cohorts/case-western-reserve-university-cwru-autopsy/) - [Case Western Reserve University (CWRU) Rapid Decline](https://dss.niagads.org/cohorts/case-western-reserve-university-cwru-rapid-decline/) - [Cuban American Alzheimer’s Disease Initiative (CuAADI)](https://dss.niagads.org/cohorts/cuban-american-alzheimers-disease-initiative-cuaadi/) - [Erasmus Rucphen Family (ERF)](https://dss.niagads.org/cohorts/erasmus-rucphen-family-erf/) - [Estudio Familiar de Influencia Genetica en Alzheimer (EFIGA)](https://dss.niagads.org/cohorts/estudio-familiar-de-influencia-genetica-en-alzheimer-efiga/) - [Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study of India (LASI-DAD)](https://dss.niagads.org/cohorts/harmonized-diagnostic-assessment-of-dementia-for-the-longitudinal-aging-study-of-india-lasi-dad/) - [Hillblom Aging Network (HAN)](https://dss.niagads.org/cohorts/hillblom-aging-network/) - [Indianapolis-Ibadan (IIAA/IIBD)](https://dss.niagads.org/cohorts/indianapolis-ibadan-iiaa/) - [Knight Alzheimer’s Disease Research Center (KGAD)](https://dss.niagads.org/cohorts/knight-alzheimers-disease-research-center-kgad/) - [LonGenity](https://dss.niagads.org/cohorts/longenity/) - [Longevity Genes Project (LGP)](https://dss.niagads.org/cohorts/longevity-genes-project-lgp/) - [Mayo Clinic (MAYO)](https://dss.niagads.org/cohorts/mayo/) - [Mexican Health and Aging Study (MHAS)](https://dss.niagads.org/cohorts/mexican-health-and-aging-study-mhas/) - [Mount Sinai Brain Bank (MSBB)](https://dss.niagads.org/cohorts/mount-sinai-brain-bank-msbb/) - [National Centralized Repository for Alzheimer’s Disease and Related Dementias Family (NCRAD Family)](https://dss.niagads.org/cohorts/national-centralized-repository-for-alzheimers-disease-and-related-dementias-family-ncrad-family/) - [National Institute of Aging Alzheimer’s Disease Family Based Study (NIA AD-FBS)](https://dss.niagads.org/cohorts/national-institute-on-aging-late-onset-of-alzheimers-disease-family-nia-load/) - [NIA Alzheimer's Disease Research Centers (ADRC)](https://dss.niagads.org/cohorts/nia-alzheimers-disease-research-centers-adrc/) - [Northern Manhattan Study (NOMAS)](https://dss.niagads.org/cohorts/northern-manhattan-study-nomas/) - [Peru Alzheimer’s Disease Initiative (PeADI)](https://dss.niagads.org/cohorts/peru-alzheimers-disease-initiative-peadi/) - [Progressive Supranuclear Palsy (PSP)](https://dss.niagads.org/cohorts/progressive-supranuclear-palsy-psp/) - [Puerto Rican 10/66 Study (PR1066)](https://dss.niagads.org/cohorts/puerto-rican-10-66-study-pr1066/) - [Puerto Rican Alzheimer’s Disease Initiative (PRADI)](https://dss.niagads.org/cohorts/puerto-rican-alzheimers-disease-initiative-pradi/) - [Religious Orders Study/Memory and Aging Project (ROSMAP)](https://dss.niagads.org/cohorts/religious-orders-study-memory-and-aging-project-rosmap/) - [Research in African-American Alzheimer’s Disease Initiative (REAAADI)](https://dss.niagads.org/cohorts/research-in-african-american-alzheimers-disease-initiative-reaaadi/) - [Stanford Extreme Phenotypes in AD (StEP AD)](https://dss.niagads.org/cohorts/stanford-extreme-phenotypes-in-ad-step-ad/) - [Texas Alzheimer’s Research and Care Consortium (TARCC)](https://dss.niagads.org/cohorts/texas-alzheimers-research-and-care-consortium-tarcc/) - [University of Miami (MIA)](https://dss.niagads.org/cohorts/university-of-miami-mia/) - [University of Miami Brain Bank (MBB)](https://dss.niagads.org/cohorts/university-of-miami-brain-bank-mbb/) - [University of Pittsburgh (PITT)](https://dss.niagads.org/cohorts/university-of-pittsburgh-pitt/) - [University of Washington Families (RAS)](https://dss.niagads.org/cohorts/university-of-washington-families-ras/) - [Vanderbilt University (VAN)](https://dss.niagads.org/cohorts/vanderbilt-university-van/) - [Washington Heights and Inwood Community Aging project (WHICAP)](https://dss.niagads.org/cohorts/washington-heights-and-inwood-community-aging-project-whicap/) - [Wisconsin Registry for Alzheimer’s Prevention (WRAP)](https://dss.niagads.org/cohorts/wisconsin-registry-for-alzheimers-prevention-wrap/) ## Sex ### Total number of samples: 31,681 Female19,63862.0 % Male12,04338.0 % ## Race ### Total number of samples: 31,681 | American Indian/Alaska Native | 126 | | --- | --- | | Asian | 2,832 | | Native Hawaiian or Other Pacific Islander | 2 | | Black or African American | 5,521 | | White | 15,852 | | Other | 4,708 | | NA | 2,640 | ## Ethnicity ### Total number of samples: 31,681 Not Hispanic or Latino 20,019 63.2% Hispanic or Latino 10,308 32.5% Not Applicable/Not Available 1,354 4.3% ## Diagnosis ### Total number of samples: 31,681 | AD | | | | --- | --- | --- | | Control | 16,186 | 51.1% | | Case | 9,684 | 30.6% | | Other | 219 | 0.7% | | Unknown | 4,895 | 15.5% | | PSP | | | | --- | --- | --- | | Case | 697 | 2.2% | ## APOE ### Total number of samples: 31,681 - 2290 (0.3%) - 231,886 (6.0%) - 24537 (1.7%) - 3313,245 (41.8%) - 347,959 (25.1%) - 441,525 (4.8%) - NA6,439 (20.3%)