---
title: "Clinical and Pathological Studies in the Oldest Old (90+ Study)"
id: "3398"
type: "study"
slug: "sa000020"
published_at: "2022-02-02T20:35:04+00:00"
modified_at: "2026-03-26T15:41:14+00:00"
url: "https://dss.niagads.org/studies/sa000020/"
markdown_url: "https://dss.niagads.org/studies/sa000020.md"
excerpt: "The 90+ Study was initiated in 2003 to study the oldest-old, the fastest growing age group in the United States. The 90+ Study is one of the largest studies of the oldest-old in the world. More than 1,600 people have..."
---

## Description

The 90+ Study was initiated in 2003 to study the oldest-old, the fastest growing age group in the United States. The 90+ Study is one of the largest studies of the oldest-old in the world. More than 1,600 people have enrolled. Initial participants in The 90+ Study were once members of The Leisure World Cohort Study (LWCS), which was started in 1981. Participants of The 90+ Study are visited every six months by researchers who perform neurological and neuropsychological tests. Our researchers at the Clinic for Aging Research and Education (CARE), located in Laguna Woods, obtain information about diet, activities, medical history, medications and numerous other factors. Additionally, participants are given a series of cognitive and physical tests to determine how well people in this age group are functioning.

## PI

Claudia Kawa, MD  
 University of California Irvine

Maria Corrada, Sc.D.  
 University of California Irvine

## Associated Datasets

- [NG00104 - Dataset from Clinical and Pathological Studies in the Oldest Old (90+ Study)](https://dss.niagads.org/datasets/ng00104/) The 90+ Study was initiated in 2003 to study the oldest-old, the fastest growing age group in the United States. The 90+ Study is one of the largest studies of… [Learn more](https://dss.niagads.org/datasets/ng00104/)

## Associated Sample Sets

- [snd10026 - 90+ GWAS GSA](https://dss.niagads.org/sample-sets/snd10026/) The 90+ sample set was genotyped at the Children's Hospital of Philadelphia using the Illumina Infinium GSAMD-24v2-0_20024620_A1 BeadChip which captures genotype data on 759,993 genomic SNPs. The standard Alzheimer's Disease… [Learn more](https://dss.niagads.org/sample-sets/snd10026/)

## Cohorts

- [Clinical and Pathological Studies in the Oldest Old (90+ Study)](https://dss.niagads.org/cohorts/clinical-and-pathological-studies-in-the-oldest-old-90-study/) The 90+ Study is one of the largest studies of the oldest-old in the world. More than 1,600 people have enrolled. Initial participants in The 90+ Study were once members… [Learn more](https://dss.niagads.org/cohorts/clinical-and-pathological-studies-in-the-oldest-old-90-study/)

## Grants

R01AG21055 and U24AG021886

## Acknowledgement

### Acknowledgment statement for any data distributed by NIAGADS:

Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer's Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.

### For investigators using Clinical and Pathological Studies in the Oldest Old (90+ Study) data:

The 90+ Study receives support through a National Institute on Aging (NIA) grant R01AG21055. We thank the staff and investigators of the study as well as the participants and their families, whose help and participation made this work possible.

Quality control procedures and data preparation on the GWAS was conducted by the Alzheimer’s Disease Genetics Consortium (ADGC) (UO1AG032984) and the NIA Genetics of Alzheimer’s Disease Storage Site (NIAGADS) (U24-AG041689), both funded by NIA.

Samples from the National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD), which receives government support under a cooperative agreement grant (U24 AG021886) awarded by the National Institute on Aging (NIA), were used in this study.

## Publications

- Corrada MM. **Dementia incidence continues to increase with age in the oldest old: the 90+ study.***Annals of neurology. 2010 Jan.*[PubMed link](https://pubmed.ncbi.nlm.nih.gov/20186856/)
- Corrada MM. **A population-based clinicopathological study in the oldest-old: the 90+ study.***Current Alzheimer research. 2012 Jul.*[PubMed link](https://pubmed.ncbi.nlm.nih.gov/22471863/)
- Corrada MM. **Apolipoprotein E genotype, dementia, and mortality in the oldest old: the 90+ Study.***Alzheimer's & dementia : the journal of the Alzheimer's Association. 2013 Jan.*[PubMed link](https://pubmed.ncbi.nlm.nih.gov/23123227/)