---
title: "NCRAD Family Study"
id: "4162"
type: "study"
slug: "sa000025"
published_at: "2022-12-13T19:41:25+00:00"
modified_at: "2022-12-13T19:41:25+00:00"
url: "https://dss.niagads.org/studies/sa000025/"
markdown_url: "https://dss.niagads.org/studies/sa000025.md"
excerpt: "The NCRAD Family Study began in 1990 and continues to actively recruit and follow subjects. Families with two or more living, biologically related, members with early or late onset AD and related dementias are enrolled. Samples are obtained from affected..."
---

## Description

The NCRAD Family Study began in 1990 and continues to actively recruit and follow subjects. Families with two or more living, biologically related, members with early or late onset AD and related dementias are enrolled. Samples are obtained from affected family members and unaffected relatives (typically over age 60). Neuropathology has been completed in over 700 NCRAD Family Study participants and brain tissue is available for over 250 of those individuals.

## PI

Tatiana M. Foroud, PhD  
 *Indiana University School of Medicine*

## Associated Datasets

- [NG00117 - NCRAD Families GWAS](https://dss.niagads.org/datasets/ng00117/) The NCRAD Families sample set was genotyped at the Children’s Hospital of Philadelphia using the Illumina Infinium GSAMD-24v2-0_20024620_A1 BeadChip which captures genotype data on 759,993 genomic SNPs. These families are… [Learn more](https://dss.niagads.org/datasets/ng00117/)
- [NG00129 - NCRAD Families WES](https://dss.niagads.org/datasets/ng00129/) This ADSP release, containing 170 whole-exomes includes 1) sequencing read alignments in CRAM (compressed BAM) format for the newly sequenced 170 samples, (2) genomic Variant Call Format (gVCF) files generated… [Learn more](https://dss.niagads.org/datasets/ng00129/)

## Cohorts

- [National Centralized Repository for Alzheimer’s Disease and Related Dementias Family (NCRAD Family)](https://dss.niagads.org/cohorts/national-centralized-repository-for-alzheimers-disease-and-related-dementias-family-ncrad-family/) The National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD) family cohort was started in 1990 and consists of families with two or more members with early or late… [Learn more](https://dss.niagads.org/cohorts/national-centralized-repository-for-alzheimers-disease-and-related-dementias-family-ncrad-family/)

## Grants

U24AG021886

## Acknowledgement

### Acknowledgment statement for any data distributed by NIAGADS:

Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer's Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.

### For investigators using NCRAD Family Study data:

Samples from the National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD), which receives government support under a cooperative agreement grant (U24AG021886) awarded by the National Institute on Aging (NIA), were used in this study. We thank the participants and their families, whose help and participation made this work possible.

For use of data in ng00117: Quality control procedures and data preparation on the GWAS was conducted by the Alzheimer’s Disease Genetics Consortium (ADGC) (UO1AG032984) and the NIA Genetics of Alzheimer’s Disease Storage Site (NIAGADS) (U24-AG041689), both funded by NIA.

For use of data in ng00129: Data processing and quality control procedures on the whole-exome dataset was conducted by the Genome Center for Alzheimer’s Disease (GCAD) (U54AG052427) and the NIA Genetics of Alzheimer’s Disease Storage Site (NIAGADS) (U24-AG041689), both funded by NIA.