---
title: "The University of Alabama Birmingham Alzheimer’s Disease Research Center (UAB ADRC)"
id: "5215"
type: "study"
slug: "sa000036"
published_at: "2023-10-04T12:58:14+00:00"
modified_at: "2026-03-26T15:49:06+00:00"
url: "https://dss.niagads.org/studies/sa000036/"
markdown_url: "https://dss.niagads.org/studies/sa000036.md"
excerpt: "This project provides exome, genome, and genotyping SNP array data (both pre-imputation and post-imputation) for the University of Alabama at Birmingham (UAB) Alzheimer’s Disease Research Center. Participants are enrolled as either cognitively unimpaired, MCI, or a target of mild dementia..."
---

## Description

This project provides exome, genome, and genotyping SNP array data (both pre-imputation and post-imputation) for the University of Alabama at Birmingham (UAB) Alzheimer’s Disease Research Center. Participants are enrolled as either cognitively unimpaired, MCI, or a target of mild dementia and followed longitudinally. The cohort aims to recruit a substantial fraction of self-reported African American / Black participants.

## PI

J.Nicholas(Nick) Cochran  
 *HudsonAlpha Institute for Biotechnology*

Erik Roberson, MD,PhD  
 *The University of Alabama Birmingham*

## Associated Datasets

- [NG00067 - ADSP Umbrella](https://dss.niagads.org/datasets/ng00067/) This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common… [Learn more](https://dss.niagads.org/datasets/ng00067/)
- [NG00135 - UAB ADRC Genetic Data](https://dss.niagads.org/datasets/ng00135/) This dataset involves whole exome, genome, and genotyping array data (both pre-imputation and post-imputation data) from the University of Alabama at Birmingham (UAB) Alzheimer’s Disease Research Center. Participants are enrolled… [Learn more](https://dss.niagads.org/datasets/ng00135/)

## Associated Sample Sets

- [snd10046 - UAB ADRC](https://dss.niagads.org/sample-sets/snd10046/) This project provides exome, genome, and genotyping SNP array data (both pre-imputation and post-imputation) for the University of Alabama at Birmingham (UAB) Alzheimer’s Disease Research Center. Participants are enrolled as… [Learn more](https://dss.niagads.org/sample-sets/snd10046/)
- [snd10099 - UAB-ADRC WGS](https://dss.niagads.org/sample-sets/snd10099/) A total of 17 samples were sequenced at HudsonAlpha Institute for Biotechnology using the NovaSeq platform. The FASTQ files were sent to GCAD for processing through the VCPA1.1 pipeline. A… [Learn more](https://dss.niagads.org/sample-sets/snd10099/)

## Cohorts

- [The University of Alabama Birmingham Alzheimer's Disease Research Center (UAB_ADRC)](https://dss.niagads.org/cohorts/the-university-of-alabama-birmingham-alzheimers-disease-research-center-uab_adrc/) The UAB Alzheimer's Disease Research Center recruits and deeply phenotypes a cohort representative of the Deep South. The cohort aims to recruit a substantial fraction of self-reported African American /… [Learn more](https://dss.niagads.org/cohorts/the-university-of-alabama-birmingham-alzheimers-disease-research-center-uab_adrc/)

## Grants

This study is supported by a research grant from the US National Institute on Aging, Grant 5P20AG068024.

## Acknowledgement

### Acknowledgment statement for any data distributed by NIAGADS:

Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer's Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.

### For investigators using University of Alabama at Birmingham Alzheimer’s Disease Research Center data:

Funding for genome sequencing was provided by the HudsonAlpha Memory and Mobility program. Funding for exome sequencing was provided by the Alzheimer’s Association. Funding for array genotyping was provided by NIA grant 5P20AG068024.

## Publications

- Wright CA. **Contributions of rare and common variation to early-onset and atypical dementia risk.***Cold Spring Harbor molecular case studies. 2023 Jun.*[PubMed link](https://pubmed.ncbi.nlm.nih.gov/37308299/)