--- title: "National Institute of Aging Alzheimer’s Disease Family Based Study (NIA AD-FBS)" id: "7289" type: "study" slug: "sa000063" published_at: "2024-11-13T14:47:29+00:00" modified_at: "2026-03-26T16:35:12+00:00" url: "https://dss.niagads.org/studies/sa000063/" markdown_url: "https://dss.niagads.org/studies/sa000063.md" excerpt: "The National Institute on Aging Alzheimer’s Disease Family Based Study (NIA AD-FBS) is the largest collection of multiplex AD families recruited and longitudinally assessed worldwide. Since 2003, the central goal of this cohort has been to broadly support genetic research..." --- ## Description The National Institute on Aging Alzheimer’s Disease Family Based Study (NIA AD-FBS) is the largest collection of multiplex AD families recruited and longitudinally assessed worldwide. Since 2003, the central goal of this cohort has been to broadly support genetic research by making clinical and genomic data and biological samples rapidly available to the AD research community to support the development of therapies to treat or prevent AD. The use of multiplex families to understand genetic susceptibility to AD began with early‐onset forms. Over the length of the project, NIA AD-FBS (formerly LOAD study) have identified environmental, health-related and genetic risk factors of disease and predictors of disease progression by collecting longitudinal data on cognitive performance, emotional health, independence in daily activities, blood pressure, cardiovascular status in this both early and late onset, multi-ethnic cohort. Sample collection includes DNA, Plasma, PBMC and Paxgene. ## PI Richard Mayeux, MD, MSc *Columbia University* ## Associated Datasets - [NG00020 - NIA AD-FBS GWAS](https://dss.niagads.org/datasets/ng00020/) The goal of the National Institute of Aging Alzheimer’s Disease Family Based Study, NIA AD-FBS (formerly National Institute on Aging Genetics Initiative for Late-Onset Alzheimer’s Disease, NIA-LOAD) is to identify… [Learn more](https://dss.niagads.org/datasets/ng00020/) - [NG00067 - ADSP Umbrella](https://dss.niagads.org/datasets/ng00067/) This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common… [Learn more](https://dss.niagads.org/datasets/ng00067/) ## Associated Sample Sets - [snd10105 - NIA-AD-FBS1 WGS](https://dss.niagads.org/sample-sets/snd10105/) A total of 999 NIA-FBS cohort samples were sequenced at NYGC on the Illumina HiSeqX platform. The BAM files were sent to GCAD for processing through the VCPA1.1 pipeline. A… [Learn more](https://dss.niagads.org/sample-sets/snd10105/) - [snd10144 - NIA AD-FBS GWAS](https://dss.niagads.org/sample-sets/snd10144/) Genotyping done by the Center for Inherited Disease Research (CIDR) was performed using the Illumina Infinium II assay protocol with hybridization to Illumina Human 610Quadv1_B Beadchips. When first deposited in… [Learn more](https://dss.niagads.org/sample-sets/snd10144/) ## Cohorts - [National Centralized Repository for Alzheimer’s Disease and Related Dementias Family (NCRAD Family)](https://dss.niagads.org/cohorts/national-centralized-repository-for-alzheimers-disease-and-related-dementias-family-ncrad-family/) The National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD) family cohort was started in 1990 and consists of families with two or more members with early or late… [Learn more](https://dss.niagads.org/cohorts/national-centralized-repository-for-alzheimers-disease-and-related-dementias-family-ncrad-family/) - [National Institute of Aging Alzheimer’s Disease Family Based Study (NIA AD-FBS)](https://dss.niagads.org/cohorts/national-institute-on-aging-late-onset-of-alzheimers-disease-family-nia-load/) The FBS collection is a longitudinal, multi-center late onset AD sibling genetics initiative. This NIA-funded study began in 2,002 and maintains DNA and cell lines on families with 2 or… [Learn more](https://dss.niagads.org/cohorts/national-institute-on-aging-late-onset-of-alzheimers-disease-family-nia-load/) - [NIA Alzheimer's Disease Research Centers (ADRC)](https://dss.niagads.org/cohorts/nia-alzheimers-disease-research-centers-adrc/) The NIA ADRC cohort included subjects ascertained and evaluated by the clinical and neuropathology cores of the 32 NIA-funded ADRCs. Data collection is coordinated by the National Alzheimer’s Coordinating Center… [Learn more](https://dss.niagads.org/cohorts/nia-alzheimers-disease-research-centers-adrc/) - [University of Washington Families (RAS)](https://dss.niagads.org/cohorts/university-of-washington-families-ras/) 131 families with LOAD (751 individuals) were ascertained and evaluated through the University of Washington Alzheimer Disease Research Center. Clinical and neuropathological assessments of cases and controls, including blood sampling,… [Learn more](https://dss.niagads.org/cohorts/university-of-washington-families-ras/) ## Grants U24AG056270 ## Acknowledgement ### Acknowledgment statement for any data distributed by NIAGADS: Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer's Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging. ### For investigators using National Institute of Aging Alzheimer’s Disease Family Based Study (NIA AD-FBS) data: The NIA-AD FBS study supported the collection of samples used in this study through National Institute on Aging (NIA) grants U24AG056270,U24AG026395, R01AG041797 and U24AG056270. We thank contributors, including the Alzheimer’s disease Centers who collected samples used in this study, as well as patients and their families, whose help and participation made this work possible. ## Publications - Reyes-Dumeyer D. **The National Institute on Aging Late-Onset Alzheimer's Disease Family Based Study: A resource for genetic discovery.***Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022 Oct.*[PubMed link](https://pubmed.ncbi.nlm.nih.gov/34978149/)