--- title: "Rush Alzheimer’s Disease Center (RADC) Studies" id: "9159" type: "study" slug: "sa000077" published_at: "2026-07-08T17:31:04+00:00" modified_at: "2026-07-22T18:09:00+00:00" url: "https://dss.niagads.org/studies/sa000077/" markdown_url: "https://dss.niagads.org/studies/sa000077.md" excerpt: "The Rush Alzheimer’s Disease Center (RADC) at Rush University Medical Center is a National Institute on Aging (NIA)-funded Alzheimer’s Disease Research Center dedicated to advancing research on Alzheimer’s disease, related dementias, and aging. For more than three decades, the RADC..." --- ## Description The Rush Alzheimer’s Disease Center (RADC) at Rush University Medical Center is a National Institute on Aging (NIA)-funded Alzheimer’s Disease Research Center dedicated to advancing research on Alzheimer’s disease, related dementias, and aging. For more than three decades, the RADC has established and maintained deeply phenotyped, longitudinal cohort studies that integrate clinical, cognitive, neuropathologic, genetic, genomic, and other multi-omics data to investigate the biological mechanisms, risk factors, progression, and resilience associated with aging and neurodegenerative disease. The RADC supports open scientific collaboration by generating and sharing high-quality research data and biospecimens from its epidemiologic cohort studies, including the Religious Orders Study (ROS), the Rush Memory and Aging Project (MAP), and other ongoing community-based cohorts. Data contributed through this study provide a resource for investigators seeking to understand the genetic and molecular basis of Alzheimer’s disease and related dementias. For more information or to request additional data or biospecimens, visit the [RADC website](https://www.radc.rush.edu/) . Website: [https://www.radc.rush.edu/](https://www.radc.rush.edu/) ## PI David Bennett *Rush Alzheimer’s Disease Center,* *Rush University Medical Center* ## Associated Datasets - [NG00029 - ROSMAP1 GWAS](https://dss.niagads.org/datasets/ng00029/) Two studies are included in this submission, the Memory and Aging Project (MAP) and the Religious Orders Study (ROS). The Religious Orders Study and the Rush Memory and Aging Project… [Learn more](https://dss.niagads.org/datasets/ng00029/) - [NG00095 - ROSMAP2 GWAS (CHOP)](https://dss.niagads.org/datasets/ng00095/) The Religious Orders Study (ROS) and Memory and Aging Project (MAP) are two community-based cohort studies. The Religious Orders Study and the Rush Memory and Aging Project are both cohort… [Learn more](https://dss.niagads.org/datasets/ng00095/) ## Associated Sample Sets - [snd10134 - ROSMAP1 GWAS](https://dss.niagads.org/sample-sets/snd10134/) The ROSMAP1 sample set was genotyped using the Affymetrix 6.0 BeadChip which captures genotype data on 906,600 genomic SNPs. The standard Alzheimer's Disease Genetics Consortium (ADGC) quality control pipeline (Naj… [Learn more](https://dss.niagads.org/sample-sets/snd10134/) - [snd10135 - ROSMAP2 GWAS](https://dss.niagads.org/sample-sets/snd10135/) The ROSMAP2 sample set was genotyped at the Children’s Hospital of Philadelphia using the Illumina Infinium OmniExpress BeadChip which captures genotype data on 730,525 genomic SNPs. The standard Alzheimer's Disease… [Learn more](https://dss.niagads.org/sample-sets/snd10135/) ## Cohorts - [Religious Orders Study/Memory and Aging Project (ROSMAP)](https://dss.niagads.org/cohorts/religious-orders-study-memory-and-aging-project-rosmap/) The Religious Orders Study (ROS) is a longitudinal, epidemiologic clinical-pathological study of memory, motor, and functional problems in older Catholic nuns, priests, and brothers aged 65 years and older from… [Learn more](https://dss.niagads.org/cohorts/religious-orders-study-memory-and-aging-project-rosmap/) ## Grants This research was supported by NIH grants P30AG10161, R01AG15819, R01AG17917, R01AG30146, U01AG32984, U01AG46152 and U01AG61356. ## Acknowledgement ### Acknowledgment statement for any data distributed by NIAGADS: Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer's Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging. ### For investigators using Rush Alzheimer’s Disease Center (RADC) Studies data: We thank the study participants and staff of the Rush Alzheimer’s Disease Center. This work was supported by NIA grants P30AG10161, R01AG15819, R01AG17917, R01AG30146, U01AG32984, U01AG46152, U01AG61356, the Illinois Department of Public Health, and the Translational Genomics Research Institute. The Alzheimer's Disease Genetics Consortium supported collection and genotyping of samples used in this study through National Institute on Aging (NIA) grants U01AG032984 and RC2AG036528. The Center for Applied Genomics at the Children’s Hospital of Philadelphia Research Institute performed genotyping of samples. Samples from the National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD), which receives government support under a cooperative agreement grant (U24 AG21886) awarded by the National Institute on Aging (NIA), were used in this study. We thank contributors who collected samples used in this study, as well as patients and their families, whose help and participation made this work possible. ## Publications - De Jager PL. **A genome-wide scan for common variants affecting the rate of age-related cognitive decline.***Neurobiology of aging. 2012 May.*[PubMed link](https://pubmed.ncbi.nlm.nih.gov/22054870/) - Bennett DA. **Overview and findings from the religious orders study.***Current Alzheimer research. 2012 Jul.*[PubMed link](https://pubmed.ncbi.nlm.nih.gov/22471860/) - Bennett DA. **Overview and findings from the rush Memory and Aging Project.***Current Alzheimer research. 2012 Jul.*[PubMed link](https://pubmed.ncbi.nlm.nih.gov/22471867/)