---
title: "Aging, Dementia, and TBI Study"
id: "9354"
type: "study"
slug: "sa000088"
published_at: "2026-09-11T13:46:54+00:00"
modified_at: "2026-09-11T13:46:54+00:00"
url: "https://dss.niagads.org/studies/sa000088/"
markdown_url: "https://dss.niagads.org/studies/sa000088.md"
excerpt: "The Aging, Dementia and Traumatic Brain Injury Study is a detailed neuropathologic, molecular and transcriptomic characterization of brains of control and TBI exposure cases from a unique aged population-based cohort from the Adult Changes in Thought (ACT) study. This study..."
---

## Description

The Aging, Dementia and Traumatic Brain Injury Study is a detailed neuropathologic, molecular and transcriptomic characterization of brains of control and TBI exposure cases from a unique aged population-based cohort from the Adult Changes in Thought (ACT) study. This study was developed by a consortium consisting of the University of Washington, Kaiser Permanente Washington Health Research Institute, and the Allen Institute for Brain Science, and was supported by the Paul G. Allen Family Foundation.

This freely available resource ([http://aging.brain-map.org/](http://aging.brain-map.org/)
) presents a systematic and extensive data set of study participant metadata, quantitative histology and protein measurements of neuropathology, and RNA sequencing (RNA-seq) analysis of hippocampus and neocortex. Specific methodological details are available on the “Documentation” tab at [http://aging.brain-map.org/](http://aging.brain-map.org/)
.

## PI

Ed Lein

*Allen Institute for Brain Science*

## Associated Datasets

- [NG00059 - Aging, Dementia, and TBI Study: RNASeq Dataset](https://dss.niagads.org/datasets/ng00059/) The Aging, Dementia and Traumatic Brain Injury Study is a detailed neuropathologic, molecular and transcriptomic characterization of brains of control and TBI exposure cases from a unique aged population-based cohort… [Learn more](https://dss.niagads.org/datasets/ng00059/)

## Associated Sample Sets

- [snd10148 - Aging, Dementia, and TBI Study: RNASeq Dataset](https://dss.niagads.org/sample-sets/snd10148/) Specific methodological details are available on the “Documentation” tab at http://aging.brain-map.org/. In short, collection of tissue samples from temporal and parietal neocortex, parietal white matter, and hippocampus was done by… [Learn more](https://dss.niagads.org/sample-sets/snd10148/)

## Cohorts

- [Adult Changes in Thought (ACT)](https://dss.niagads.org/cohorts/adult-changes-in-thought-act/) The Adult Changes in Thought (ACT) study is a longitudinal prospective cohort study that began in 1994. Participants are randomly selected from Seattle area members of Group Health aged 65… [Learn more](https://dss.niagads.org/cohorts/adult-changes-in-thought-act/)

## Grants

U01 AG046152, P50 AG016574, U01 AG032984, R01 AG030146, R01 AG017917, P50 AG005136, P30 AG010161, R01 AG032990, R01 NS080820, U01 AG006781, U01 AG046139, P01 AG003949, U24 NS072026, P30 AG019610, P50 AG025711, P01 AG017216, R01 AG018023, U01 AG006786, R01 AG036836, R01 AG015819

## Acknowledgement

### Acknowledgment statement for any data distributed by NIAGADS:

Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer's Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.

### For investigators using Aging, Dementia, and TBI Study data:

We thank the Allen Institute for Brain Science founders, P.G. Allen and J. Allen, for their vision, encouragement, and support. The study was supported by the Paul G. Allen Family Foundation (PIs: Richard Ellenbogen and C. Dirk Keene, University of Washington; PI: Eric Larson, Kaiser Permanente Washington Health Research Institute; and PI: Ed Lein, Allen Institute for Brain Science).

## Publications

- Miller JA. **Neuropathological and transcriptomic characteristics of the aged brain.***eLife. 2017 Nov 9.*[PubMed link](https://pubmed.ncbi.nlm.nih.gov/29120328/)