Participants include persons of Mexican origin affected by or known to be at 50% risk for the development of autosomal dominant Alzheimer’s disease (ADAD) due to the A431E mutation in PSEN1 or the V717I mutation in APP.  This includes legacy DNA and data collected prior to funding and prospective data being collected under NIH/NIA/FIC, R01AG069013, “Phenotype and Genotype of Autosomal Dominant Alzheimer’s Disease in Jalisco, Mexico.” 

Prospective participants are enrolled in Guadalajara or Los Angeles and undergo the UDS3, becoming part of the ADRC of the University of Southern California (USC) with their UDS packets submitted to the National Alzheimer Coordinating Center (NACC).  They are then followed annually using this protocol and those in Los Angeles asked to participate in the brain autopsy program of the USC ADRC.  Additional clinical data and resources (e.g. blood samples, imaging) are variably available for participants.