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    Showing 54 datasets
  • Data Type: 
    Summary Statistics
    Disease: 
    AD
    Open and Controlled Access Data: 
    Controlled AccessOpen Access
    Last Release Date: May 15, 2024
    Files: 12
    Total size: 52GB
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    CHARGE investigators performed single common variant association, rare variant aggregate analyses, and targeted association analyses in sub-populations using the R1 WGS data from the Alzheimer’s Disease Sequencing Project (ADSP) to identify causal and rare variants that were linked to loci from the...
  • Data Type: 
    Single Cell RNA SequencingSingle-cell ATAC SequencingSingle-cell WGS
    Disease: 
    Aging
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina NovaSeq 6000
    Last Release Date: May 14, 2024
    Subjects: 15
    Files: 256
    Total size: 1TB
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    Characterizing the mechanisms of somatic mutations in the brain is important for understanding aging and disease, but little is known about the mutational patterns of different cell types. We performed whole-genome sequencing of 86 single oligodendrocytes, 20 mixed glia, and 56 single...
  • Data Type: 
    Summary Statistics
    Disease: 
    AD
    Open and Controlled Access Data: 
    Controlled AccessOpen Access
    Last Release Date: March 6, 2024
    Files: 14
    Total size: 8GB
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    This dataset contains the sex stratified and interaction summary statistics memory and memory slopes published in Eissman, et al, 2022 (Brain, PMID: 35552371). Cognitive and pathology data were harmonized across two datasets with autopsy measures of amyloid (ROS/MAP and ACT) and two...
  • Data Type: 
    Summary Statistics
    Open and Controlled Access Data: 
    Controlled AccessOpen Access
    Last Release Date: December 21, 2023
    Files: 20
    Total size: 8GB
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    This dataset contains the sex stratified and interaction summary statistics memory and memory slopes published in Eissman, et al, 2023 (Alzheimer’s and Dementia, PMID: 37984853). Memory scores were obtained from multiple ADSP cohorts (ACT, ADNI, NACC, ROS/MAP/MARS) at baseline and longitudinally. Memory...
  • Data Type: 
    Summary Statistics
    Disease: 
    AD
    Open and Controlled Access Data: 
    Controlled AccessOpen Access
    Last Release Date: February 12, 2024
    Files: 8
    Total size: 3GB
    lock iconControlled Access Files
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    Clinical AD diagnosis has been the focus of most genome-wide association studies of Alzheimer’s disease. Memory performance has received less attention even though it is a strong endophenotype for AD and is highly heritable. A major challenge in performing large-scale genomic analysis...
  • Data Type: 
    Summary Statistics
    Disease: 
    AD
    Open and Controlled Access Data: 
    Controlled AccessOpen Access
    Last Release Date: March 6, 2024
    Files: 8
    Total size: 3GB
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    Autopsy measures of Alzheimer’s disease neuropathology have been leveraged as endophenotypes in previous genome-wide association studies (GWAS). However, despite evidence of sex differences in Alzheimer’s disease risk, sex-stratified models have not been incorporated into previous GWAS analyses. We looked for sex-specific genetic...
  • Data Type: 
    Summary Statistics
    Disease: 
    AD
    Open and Controlled Access Data: 
    Controlled AccessOpen Access
    Last Release Date: March 6, 2024
    Files: 11
    Total size: 4GB
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    Cerebrospinal fluid (CSF) levels of amyloid-β 42 (Aβ42) and tau have been evaluated as endophenotypes in Alzheimer’s disease (AD) genetic studies. Although there are sex differences in AD risk, sex differences have not been evaluated in genetic studies of AD endophenotypes. We...
  • Data Type: 
    Summary Statistics
    Disease: 
    AD
    Open and Controlled Access Data: 
    Controlled AccessOpen Access
    Last Release Date: March 6, 2024
    Files: 6
    Total size: 2GB
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    Approximately 30% of older adults exhibit the neuropathological features of Alzheimer’s disease without signs of cognitive impairment. Yet, little is known about the genetic factors that allow these potentially resilient individuals to remain cognitively unimpaired in the face of substantial neuropathology. This...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    PD
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina Infinium Global Screening Array-24 Kit
    Last Release Date: December 8, 2023
    Subjects: 292
    Files: 1
    Total size: 8GB
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    One of the most common Alzheimer’s Disease Related Dementias (ADRD) is Lewy body dementia. This umbrella term comprises two clinically distinct ADRDs: Parkinson’s disease dementia (PD-dementia) and dementia with Lewy bodies (DLB). There has been a growing interest in the genetic bases...
  • Data Type: 
    Methylation
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina Infinium MethylationEPIC v1.0
    Last Release Date: December 15, 2023
    Subjects: 4,018
    Files: 14
    Total size: 60GB
    lock iconControlled Access Files
    DNA methylation assays were conducted on a non-random subsample (n=4,104) of participants who participated in the 2016 Venous Blood Study. The sample includes all the participants of the 2016 Healthy Cognitive Aging Project (HCAP) who have provided blood samples, plus younger participants...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Imputation: 
    TOPMed r2
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina Infinium Global Screening Array-24 Kit
    Last Release Date: February 7, 2024
    Subjects: 894
    Files: 176
    Total size: 227GB
    lock iconControlled Access Files
    This GWAS dataset, ADC15, is the fifteen set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing Alzheimer’s disease. Provided here, are the PLINK genotype files that have undergone...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Imputation: 
    TOPMed r2
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina Infinium Global Screening Array-24 Kit
    Last Release Date: February 7, 2024
    Subjects: 4,620
    Files: 293
    Total size: 465GB
    lock iconControlled Access Files
    This GWAS dataset, ADC14, is the fourteenth set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing Alzheimer’s disease. Provided here, are the PLINK genotype files that have undergone...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Imputation: 
    TOPMed r2
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina Infinium Global Screening Array-24 Kit
    Last Release Date: February 6, 2024
    Subjects: 1,442
    Files: 208
    Total size: 276GB
    lock iconControlled Access Files
    This GWAS dataset, ADC13, is the thirteenth set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing Alzheimer’s disease. Provided here, are the PLINK genotype files that have undergone...
  • Data Type: 
    TRA Recombination Reads
    Disease: 
    ADRD
    Open and Controlled Access Data: 
    Open Access
    Last Release Date: September 22, 2023
    Files: 4
    Total size: 4MB
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    Despite the fact that only modest adaptive immune system related approaches to treating Alzheimer’s disease (AD) are available, an immunogenomics approach to the study of Alzheimer’s disease has not yet substantially advanced.  Thus, we characterized T-cell receptor alpha (TRA) complementarity determining region-3...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    DementiaMCI
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina Infinium Global Screening Array-24 Kit
    Last Release Date: March 15, 2024
    Subjects: 1,647
    Files: 6
    Total size: 653MB
    lock iconControlled Access Files
    The ANGI GWAS dataset includes demographics, APOE genotype, and GWAS data for participants from the ANGI cohort. This dataset also includes amyloid PET scan results (positive, negative, uninterpretable, not yet reported), level of cognitive impairment (no impairment, MCI, Dementia), year of onset...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    Dementia
    Platform: 
    Illumina Infinium Global Screening Array-24 Kit
    Last Release Date: March 27, 2024
    Subjects: 390
    Files: 3
    Total size: 17GB
    lock iconControlled Access Files
    This dataset includes individual level data from Singapore-Longitudinal study of Vascular Cognitive Impairment and Dementia. This includes both genotyping (raw and imputed) on the Infinium Global Screening Array-24 Kit as well as phenotypic data including age, sex, and overall cognitive diagnosis. There...
  • Data Type: 
    Targeted Genotyping
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    TaqMan
    Last Release Date: March 1, 2024
    Subjects: 1,245
    Files: 3
    Total size: 558KB
    lock iconControlled Access Files
    The Colorado Adoption/Twin Study of Lifespan behavioral development & cognitive aging (CATSLife) aims are to: conduct a genetically sensitive study of individual differences in behavioral and cognitive change at the cusp of middle adulthood, in participants from the Colorado Adoption Project (CAP)...
  • Data Type: 
    Risk Scores
    Disease: 
    AD
    Open and Controlled Access Data: 
    Controlled Access
    Last Release Date: August 22, 2023
    Files: 18
    Total size: 19KB
    lock iconControlled Access Files
    To better capture the polygenic architecture of Alzheimer’s Disease (AD), we developed a joint genetic score, MetaGRS. We incorporated genetic variants for AD and 24 other traits from two independent cohorts, NACC (n = 3,174, training set) and UPitt (n = 2,053,...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Imputation: 
    TOPMed r2
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina Infinium Global Screening Array-24 Kit
    Last Release Date: February 6, 2024
    Subjects: 1,320
    Files: 206
    Total size: 271GB
    lock iconControlled Access Files
    This GWAS dataset, ADC12, is the twelfth set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing Alzheimer’s disease. Provided here, are the PLINK genotype files that have undergone...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Imputation: 
    TOPMed r2
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina Infinium Global Screening Array-24 Kit
    Last Release Date: February 7, 2024
    Subjects: 2,679
    Files: 256
    Total size: 370GB
    lock iconControlled Access Files
    This GWAS dataset, ADC11, is the eleventh set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing Alzheimer’s disease. Provided here, are the PLINK genotype files that have undergone...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Imputation: 
    TOPMed r2
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina Infinium Global Screening Array-24 Kit
    Last Release Date: February 7, 2024
    Subjects: 3,744
    Files: 262
    Total size: 405GB
    lock iconControlled Access Files
    This GWAS dataset, ADC10, is the tenth set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing Alzheimer’s disease. Provided here, are the PLINK genotype files that have undergone...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Imputation: 
    TOPMed r2
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina Infinium Global Screening Array-24 Kit
    Last Release Date: February 6, 2024
    Subjects: 2,084
    Files: 165
    Total size: 237GB
    lock iconControlled Access Files
    This GWAS dataset, ADC9, is the ninth set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing Alzheimer’s disease. Provided here, are the PLINK genotype files that have undergone...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Imputation: 
    TOPMed r2
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina OmniExpress Exome
    Last Release Date: February 6, 2024
    Subjects: 2,359
    Files: 315
    Total size: 303GB
    lock iconControlled Access Files
    This GWAS dataset, ADC8, is the eighth set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing Alzheimer’s disease. Provided here, are the PLINK genotype files that have undergone...
  • Data Type: 
    Genotyping SNP ArrayWhole Exome SequencingWhole Genome Sequencing
    Disease: 
    Dementia
    Imputation: 
    TOPMed r2
    Platform: 
    Illumina Global Diversity ArrayIllumina NovaSeq 6000
    Last Release Date: October 4, 2023
    Subjects: 81
    Files: 1
    Total size: 906MB
    lock iconControlled Access Files
    This dataset involves whole exome, genome, and genotyping array data (both pre-imputation and post-imputation data) from the University of Alabama at Birmingham (UAB) Alzheimer’s Disease Research Center. Participants are enrolled as either cognitively unimpaired, MCI, or a target of mild dementia and...
  • Data Type: 
    Genotyping SNP Array
    Imputation: 
    TOPMed r2
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina Infinium Global Screening Array-24 Kit
    Last Release Date: June 1, 2023
    Subjects: 4,006
    Files: 8
    Total size: 343GB
    lock iconControlled Access Files
    A dried blood spot (DBS) collection in Round 7 (2017) of NHATS provided the biological material for genotyping. Samples were genotyped at Erasmus Medical Center in Rotterdam, Netherlands on the Illumina Infinium Global Screening Array v3.0. The array contains clinical and rare...
  • Data Type: 
    Summary Statistics
    Disease: 
    AD
    Last Release Date: May 4, 2023
    Files: 3
    Total size: 1KB
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    Resveratrol exhibits a wide range of biological properties, including anti-glycation, antioxidant, anti-inflammation, neuroprotective (including against advanced dementia and Alzheimer’s disease), anti-cancer, and anti-aging activity in experimental models. Unfortunately, this compound exhibits low bioavailability and solubility, requiring large doses that can cause nausea...
  • Data Type: 
    Targeted Genotyping
    Platform: 
    TaqManThermo Hybaid MBS 0.2S
    Last Release Date: April 7, 2023
    Subjects: 19,193
    Files: 2
    Total size: 1MB
    lock iconControlled Access Files
    The APOE and Serotonin Transporter Alleles data product includes data for the APOE isoform, directly genotyped using a TaqMan allelic discrimination SNP assay, where available, or imputed from preexisting genotype array data otherwise. This file also includes human serotonin transporter (5HTTLPR) short...
  • Data Type: 
    QTL Summary Statistics
    Disease: 
    ADRD
    Open and Controlled Access Data: 
    Controlled AccessOpen Access
    Platform: 
    Metabolon HD4
    Last Release Date: August 10, 2023
    Files: 1,414
    Total size: 749GB
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    The majority of metabolite quantitative trait loci (MQTL) were discovered using blood and urine tissues. This data represents the first large-scaled CSF and brain study, which will advance the understanding of genetic regulation in metabolite levels by identifying novel MQTLs. For 440...
  • Data Type: 
    QTL Summary Statistics
    Disease: 
    ADRD
    Open and Controlled Access Data: 
    Controlled AccessOpen Access
    Platform: 
    Somalogic SomaScan
    Last Release Date: July 27, 2023
    Files: 7,034
    Total size: 2TB
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    Quantitative trait locus (QTL) analysis has proven successful in the identification of causal genes at disease loci, but many of these loci still do not clearly link to genes. These QTL studies are either highly specific to plasma (for proteomics) or are...
  • Data Type: 
    Whole Exome Sequencing
    Disease: 
    AD
    Platform: 
    Illumina NovaSeq 6000
    Last Release Date: March 8, 2023
    Subjects: 170
    Files: 354
    Total size: 930GB
    lock iconControlled Access Files
    This ADSP release, containing 170 whole-exomes includes 1) sequencing read alignments in CRAM (compressed BAM) format for the newly sequenced 170 samples, (2) genomic Variant Call Format (gVCF) files generated by GATK4.1.1 on samples. The pVCF released here is provided as a...
  • Data Type: 
    Proteomic/Metabolomic
    Disease: 
    COVID-19
    Platform: 
    Somalogic SomaScan
    Last Release Date: January 18, 2023
    Subjects: 482
    Files: 8
    Total size: 36MB
    lock iconControlled Access Files
    The goal of WU350 cohort is to address the many complexities of the COVID-19 pandemic. Among the 332 COVID-19 cases, ~90% were symptomatic patients, 93.7% were hospitalized, 46.7% with ICU admission, 24.7% on ventilation, and 19.0% died due to COVID-19 (82 ventilated...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Last Release Date: December 13, 2022
    Subjects: 4,496
    Files: 8
    Total size: 2GB
    lock iconControlled Access Files
    The search for novel risk factors for Alzheimer disease relies on access to accurate and deeply phenotyped datasets. The Memory and Aging Project at the Knight-ADRC (Knight ADRC-MAP) collects plasma, CSF, fibroblast, neuroimaging clinical and cognition data longitudinally and autopsied brain samples....
  • Data Type: 
    Summary StatisticsWhole Exome SequencingWhole Genome Sequencing
    Disease: 
    AD
    Open and Controlled Access Data: 
    Controlled AccessOpen Access
    Last Release Date: December 13, 2022
    Files: 12
    Total size: 5GB
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    We performed Whole-exome and Whole-Genome association analyses with Alzheimer’s disease risk in ADSP data (NG00067.v5), focusing on non-Hispanic white individuals of European ancestry. Specifically, we designed novel variant filters that account for variant frequency differences across sequencing centers/platforms in the ADSP data....
  • Data Type: 
    Single-neuron WGS
    Disease: 
    AD
    Platform: 
    Illumina
    Last Release Date: May 12, 2022
    Subjects: 29
    Files: 353
    Total size: 62TB
    lock iconControlled Access Files
    Single-neuron amplified genome libraries were sequenced (WGS) on Illumina instruments and aligned to the human reference genome GRCh37. Linked-read analysis (LiRA) and SCAN-SNV were used to identify single-cell somatic mutations. The single-cell dataset includes a total of 319 single-neuron genome sequences (172...
  • Data Type: 
    Genotyping SNP Array
    Imputation: 
    1000G Phase3v5HRC
    Platform: 
    Illumina HumanOmni2.5-Quad
    Last Release Date: January 27, 2022
    Subjects: 19,042
    Files: 6
    Total size: 763GB
    lock iconControlled Access Files
    These data include a total of 18,916 subjects from the Health and Retirement Study genotyped on Illumina HumanOmni2.5-arrays.  Data files also include imputed data using the 1000 Genomes and the Haplotype Reference Consortium (HRC) reference panels. Respondents who consented to the saliva...
  • Data Type: 
    QTL Summary StatisticsStructural Variant Calls
    Disease: 
    ADPSP
    Platform: 
    Illumina HiSeq X
    Last Release Date: April 24, 2023
    Subjects: 1,369
    Files: 29
    Total size: 2GB
    lock iconControlled Access Files
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    Structural variants (SVs) were discovered in 1,760 donors by running a combination of seven different tools to capture the main classes of variation, including deletions (DEL), duplications (DUP), insertions (INS), inversions (INV), mobile element insertions (MEI), and complex rearrangements (CPX). We mapped...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Platform: 
    Illumina Infinium Global Screening Array-24 Kit
    Last Release Date: November 22, 2022
    Subjects: 698
    Files: 9
    Total size: 146MB
    lock iconControlled Access Files
    The NCRAD Families sample set was genotyped at the Children’s Hospital of Philadelphia using the Illumina Infinium GSAMD-24v2-0_20024620_A1 BeadChip which captures genotype data on 759,993 genomic SNPs. These families are not evaluated in person. Family history and demographic data are collected and...
  • Data Type: 
    Camouflaged VariantsWhole Exome SequencingWhole Genome Sequencing
    Disease: 
    AD
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina HiSeq 2000Illumina HiSeq 2500Illumina HiSeq 3000Illumina HiSeq X
    Last Release Date: February 28, 2024
    Subjects: 14,314
    Files: 38
    Total size: 13GB
    lock iconControlled Access Files
    Many regions of the human genome present challenges that prohibit scientists from discovering potential disease-causing mutations. We developed methods to characterize mutations in these regions to rescue mutations that are otherwise overlooked. PMID: 31104630 Provided here are variant calls in VCF format...
  • Data Type: 
    Methylation
    Disease: 
    ADRD
    Last Release Date: February 4, 2022
    Subjects: 413
    Files: 7
    Total size: 6GB
    lock iconControlled Access Files
    Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder with many biological processes, and molecular changes. The etiology of AD is complex and not specific to a single genetic factor. Epigenetic changes could help explain the missing heritability not capture in GWAS chips...
  • Data Type: 
    Proteomic/Metabolomic
    Disease: 
    ADRD
    Last Release Date: February 4, 2022
    Subjects: 423
    Files: 13
    Total size: 13MB
    lock iconControlled Access Files
    The identification of genetic risk factors for Alzheimer’s Disease (AD) provides additional to support that multiple pathways contribute to its onset and progression. However, the metabolomic and lipidomic profiles altered among carriers of distinct genetic risk factors is not fully understood. The...
  • Data Type: 
    Single Cell RNA Sequencing
    Disease: 
    AD
    Platform: 
    10X Genomics Single Cell Gene Expression v3.1
    Last Release Date: November 23, 2021
    Subjects: 44
    Files: 14
    Total size: 1TB
    lock iconControlled Access Files
    Alzheimer’s disease (AD) is the most prevalent cause of dementia. While there is no effective treatment for AD, a growing body of evidence points to passive immunotherapy with monoclonal antibodies against amyloid beta (Aβ) as a promising therapeutic strategy. Meningeal lymphatic drainage...
  • Data Type: 
    Genotyping SNP Array
    Imputation: 
    1000G Phase3v5TOPMed r2
    Platform: 
    Illumina Infinium Global Screening Array-24 Kit
    Last Release Date: September 16, 2021
    Subjects: 993
    Files: 57
    Total size: 182GB
    lock iconControlled Access Files
    In 2018, 960 respondents from LASI-DAD who consented to the blood sample collection have been genotyped using Illumina Infinium genotyping platforms. The datasets being submitted include the original genotype assayed by the genotyping platforms, imputed data to the 1000G reference panel, as...
  • Data Type: 
    Genotyping SNP ArrayShort-Read RNA SequencingSingle Cell RNA Sequencing
    Disease: 
    Neuropsychiatric Brain Disorders
    Platform: 
    Illumina HiSeq 2500Illumina Infinium Global Screening Array-24 Kit
    Last Release Date: May 29, 2024
    Subjects: 131
    Files: 288
    Total size: 3TB
    lock iconControlled Access Files
    unlock iconOpen Access Files
    Microglia Genomic Atlas – MiGA (NG00105.v1): Post-mortem brain samples were obtained from the Netherlands Brain Bank (NBB). The permission to collect human brain material was obtained from the Ethical Committee of the VU University Medical Center, Amsterdam, The Netherlands. Informed consent for...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Platform: 
    Illumina Infinium Global Screening Array-24 Kit
    Last Release Date: February 4, 2022
    Subjects: 268
    Files: 9
    Total size: 73MB
    lock iconControlled Access Files
    The 90+ Study was initiated in 2003 to study the oldest-old, the fastest growing age group in the United States. The 90+ Study is one of the largest studies of the oldest-old in the world. More than 1,600 people have enrolled. Initial...
  • Data Type: 
    Summary Statistics
    Disease: 
    AD
    Open and Controlled Access Data: 
    Controlled AccessOpen Access
    Last Release Date: March 6, 2024
    Files: 3
    Total size: 374MB
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    Genetic studies of Alzheimer disease have focused on the clinical or pathologic diagnosis as the primary outcome, but little is known about the genetic basis of the preclinical phase of the disease. The objective of this study was to examine the underlying...
  • Data Type: 
    Proteomic/MetabolomicQTL Summary Statistics
    Disease: 
    AD
    Open and Controlled Access Data: 
    Controlled AccessOpen Access
    Platform: 
    Somalogic SomaScan
    Last Release Date: November 7, 2023
    Subjects: 1,157
    Files: 31
    Total size: 361GB
    lock iconControlled Access Files
    unlock iconOpen Access Files
    Understanding the tissue-specific genetic controls of protein levels is essential to uncover mechanisms of post-transcriptional gene regulation. We previously generated a genomic atlas of protein levels in three tissues relevant to neurological disorders (brain, cerebrospinal fluid and plasma) by profiling thousands of...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Imputation: 
    TOPMed r2
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina OmniExpress Exome
    Last Release Date: February 6, 2024
    Subjects: 1,467
    Files: 113
    Total size: 113GB
    lock iconControlled Access Files
    This GWAS dataset, ADC7, is the seventh set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing Alzheimer’s disease. Provided here, are the PLINK genotype files that have undergone...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Imputation: 
    TOPMed r2
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina HumanOmniExpress-12
    Last Release Date: February 6, 2024
    Subjects: 1,330
    Files: 91
    Total size: 116GB
    lock iconControlled Access Files
    This GWAS dataset, ADC6, is the sixth set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing Alzheimer’s disease. Provided here, are the PLINK genotype files that have undergone...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Imputation: 
    TOPMed r2
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina HumanOmniExpress-12
    Last Release Date: February 6, 2024
    Subjects: 1,222
    Files: 91
    Total size: 112GB
    lock iconControlled Access Files
    This GWAS dataset, ADC5, is the fifth set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing Alzheimer’s disease. Provided here, are the PLINK genotype files that have undergone...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Imputation: 
    TOPMed r2
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina HumanOmniExpress-12
    Last Release Date: February 6, 2024
    Subjects: 1,054
    Files: 91
    Total size: 104GB
    lock iconControlled Access Files
    This GWAS dataset, ADC4, is the fouth set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing Alzheimer’s disease. Provided here, are the PLINK genotype files that have undergone...
  • Data Type: 
    AnnotationHarmonized PhenotypesStructural Variant CallsWhole Exome SequencingWhole Genome Sequencing
    Open and Controlled Access Data: 
    Controlled AccessOpen Access
    Last Release Date: March 4, 2024
    Subjects: 62,475
    Files: 131,025
    Total size: 1320TB
    lock iconControlled Access Files
    unlock iconOpen Access Files
    This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common workflow called VCPA (Variant Calling Pipeline and data management tool), a functionally...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Imputation: 
    TOPMed r2
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina HumanOmniExpress-12
    Last Release Date: February 6, 2024
    Subjects: 2,040
    Files: 157
    Total size: 206GB
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    This GWAS dataset, ADC3, is the third set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing Alzheimer’s disease. Provided here, are the PLINK genotype files that have undergone...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Imputation: 
    TOPMed r2
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina Human660W-Quad
    Last Release Date: February 6, 2024
    Subjects: 925
    Files: 75
    Total size: 93GB
    lock iconControlled Access Files
    This GWAS dataset, ADC2, is the second set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing Alzheimer’s disease. Provided here, are the PLINK genotype files that have undergone...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Imputation: 
    TOPMed r2
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina Human660W-Quad
    Last Release Date: February 6, 2024
    Subjects: 2,768
    Files: 146
    Total size: 224GB
    lock iconControlled Access Files
    This GWAS dataset, ADC1, is the first set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing Alzheimer’s disease. Provided here, are the PLINK genotype files that have undergone...