Thank you for your patience as the datasets in the NIAGADS database are transferred to the DSS database. Can't find the dataset you are looking for? Check the NIAGADS database.
  • Data Type: 
    TRA Recombination Reads
    Disease: 
    ADRD
    Open and Controlled Access Data: 
    Open Access
    Last Release Date: September 22, 2023
    Files: 4
    Total size: 4MB
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    Despite the fact that only modest adaptive immune system related approaches to treating Alzheimer’s disease (AD) are available, an immunogenomics approach to the study of Alzheimer’s disease has not yet substantially advanced.  Thus, we characterized T-cell receptor alpha (TRA) complementarity determining region-3...
  • Data Type: 
    Risk Scores
    Disease: 
    AD
    Open and Controlled Access Data: 
    Controlled Access
    Last Release Date: August 22, 2023
    Files: 18
    Total size: 19KB
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    To better capture the polygenic architecture of Alzheimer’s Disease (AD), we developed a joint genetic score, MetaGRS. We incorporated genetic variants for AD and 24 other traits from two independent cohorts, NACC (n = 3,174, training set) and UPitt (n = 2,053,...
  • Data Type: 
    Genotyping SNP ArrayWESWGS
    Disease: 
    Dementia
    Imputation: 
    TOPMed r2
    Platform: 
    Illumina Global Diversity ArrayIllumina NovaSeq 6000
    Last Release Date: September 1, 2022
    Subjects: 81
    Files: 1
    Total size: 906MB
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    This dataset involves whole exome, genome, and genotyping array data (both pre-imputation and post-imputation data) from the University of Alabama at Birmingham (UAB) Alzheimer’s Disease Research Center. Participants are enrolled as either cognitively unimpaired, MCI, or a target of mild dementia and...
  • Data Type: 
    Genotyping SNP Array
    Imputation: 
    TOPMed r2
    Open and Controlled Access Data: 
    Controlled Access
    Platform: 
    Illumina Infinium Global Screening Array-24 Kit
    Last Release Date: June 1, 2023
    Subjects: 4,006
    Files: 8
    Total size: 343GB
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    A dried blood spot (DBS) collection in Round 7 (2017) of NHATS provided the biological material for genotyping. Samples were genotyped at Erasmus Medical Center in Rotterdam, Netherlands on the Illumina Infinium Global Screening Array v3.0. The array contains clinical and rare...
  • Data Type: 
    Summary Statistics
    Disease: 
    AD
    Last Release Date: May 4, 2023
    Files: 3
    Total size: 1KB
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    Resveratrol exhibits a wide range of biological properties, including anti-glycation, antioxidant, anti-inflammation, neuroprotective (including against advanced dementia and Alzheimer’s disease), anti-cancer, and anti-aging activity in experimental models. Unfortunately, this compound exhibits low bioavailability and solubility, requiring large doses that can cause nausea...
  • Data Type: 
    Targeted Genotyping
    Platform: 
    TaqManThermo Hybaid MBS 0.2S
    Last Release Date: April 7, 2023
    Subjects: 19,193
    Files: 2
    Total size: 1MB
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    The APOE and Serotonin Transporter Alleles data product includes data for the APOE isoform, directly genotyped using a TaqMan allelic discrimination SNP assay, where available, or imputed from preexisting genotype array data otherwise. This file also includes human serotonin transporter (5HTTLPR) short...
  • Data Type: 
    QTL Summary Statistics
    Disease: 
    ADRD
    Open and Controlled Access Data: 
    Controlled AccessOpen Access
    Platform: 
    Metabolon HD4
    Last Release Date: August 10, 2023
    Files: 1,414
    Total size: 749GB
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    The majority of metabolite quantitative trait loci (MQTL) were discovered using blood and urine tissues. This data represents the first large-scaled CSF and brain study, which will advance the understanding of genetic regulation in metabolite levels by identifying novel MQTLs. For 440...
  • Data Type: 
    QTL Summary Statistics
    Disease: 
    ADRD
    Open and Controlled Access Data: 
    Controlled AccessOpen Access
    Platform: 
    Somalogic SomaScan
    Last Release Date: July 27, 2023
    Files: 7,034
    Total size: 2TB
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    Quantitative trait locus (QTL) analysis has proven successful in the identification of causal genes at disease loci, but many of these loci still do not clearly link to genes. These QTL studies are either highly specific to plasma (for proteomics) or are...
  • Data Type: 
    WES
    Disease: 
    AD
    Platform: 
    Illumina NovaSeq 6000
    Last Release Date: March 8, 2023
    Subjects: 170
    Files: 354
    Total size: 930GB
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    This ADSP release, containing 170 whole-exomes includes 1) sequencing read alignments in CRAM (compressed BAM) format for the newly sequenced 170 samples, (2) genomic Variant Call Format (gVCF) files generated by GATK4.1.1 on samples. The pVCF released here is provided as a...
  • Data Type: 
    Proteomic/Metabolomic
    Disease: 
    COVID-19
    Platform: 
    Somalogic SomaScan
    Last Release Date: January 18, 2023
    Subjects: 482
    Files: 8
    Total size: 36MB
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    The goal of WU350 cohort is to address the many complexities of the COVID-19 pandemic. Among the 332 COVID-19 cases, ~90% were symptomatic patients, 93.7% were hospitalized, 46.7% with ICU admission, 24.7% on ventilation, and 19.0% died due to COVID-19 (82 ventilated...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Last Release Date: December 13, 2022
    Subjects: 4,496
    Files: 8
    Total size: 2GB
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    The search for novel risk factors for Alzheimer disease relies on access to accurate and deeply phenotyped datasets. The Memory and Aging Project at the Knight-ADRC (Knight ADRC-MAP) collects plasma, CSF, fibroblast, neuroimaging clinical and cognition data longitudinally and autopsied brain samples....
  • Data Type: 
    Summary StatisticsWESWGS
    Disease: 
    AD
    Open and Controlled Access Data: 
    Controlled AccessOpen Access
    Last Release Date: December 13, 2022
    Files: 12
    Total size: 5GB
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    We performed Whole-exome and Whole-Genome association analyses with Alzheimer’s disease risk in ADSP data (NG00067.v5), focusing on non-Hispanic white individuals of European ancestry. Specifically, we designed novel variant filters that account for variant frequency differences across sequencing centers/platforms in the ADSP data....
  • Data Type: 
    Single-neuron WGS
    Disease: 
    AD
    Platform: 
    Illumina
    Last Release Date: May 12, 2022
    Subjects: 29
    Files: 353
    Total size: 62TB
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    Single-neuron amplified genome libraries were sequenced (WGS) on Illumina instruments and aligned to the human reference genome GRCh37. Linked-read analysis (LiRA) and SCAN-SNV were used to identify single-cell somatic mutations. The single-cell dataset includes a total of 319 single-neuron genome sequences (172...
  • Data Type: 
    Genotyping SNP Array
    Imputation: 
    1000G Phase3v5HRC
    Platform: 
    Illumina HumanOmni2.5-Quad
    Last Release Date: January 27, 2022
    Subjects: 19,042
    Files: 6
    Total size: 763GB
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    These data include a total of 18,916 subjects from the Health and Retirement Study genotyped on Illumina HumanOmni2.5-arrays.  Data files also include imputed data using the 1000 Genomes and the Haplotype Reference Consortium (HRC) reference panels. Respondents who consented to the saliva...
  • Data Type: 
    QTL Summary StatisticsWGS
    Disease: 
    ADPSP
    Platform: 
    Illumina HiSeq X
    Last Release Date: April 24, 2023
    Subjects: 1,369
    Files: 29
    Total size: 2GB
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    Structural variants (SVs) were discovered in 1,760 donors by running a combination of seven different tools to capture the main classes of variation, including deletions (DEL), duplications (DUP), insertions (INS), inversions (INV), mobile element insertions (MEI), and complex rearrangements (CPX). We mapped...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Platform: 
    Illumina Infinium Global Screening Array-24 Kit
    Last Release Date: November 22, 2022
    Subjects: 698
    Files: 9
    Total size: 146MB
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    The NCRAD Families sample set was genotyped at the Children’s Hospital of Philadelphia using the Illumina Infinium GSAMD-24v2-0_20024620_A1 BeadChip which captures genotype data on 759,993 genomic SNPs. These families are not evaluated in person. Family history and demographic data are collected and...
  • Data Type: 
    Methylation
    Disease: 
    ADRD
    Last Release Date: February 4, 2022
    Subjects: 413
    Files: 7
    Total size: 6GB
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    Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder with many biological processes, and molecular changes. The etiology of AD is complex and not specific to a single genetic factor. Epigenetic changes could help explain the missing heritability not capture in GWAS chips...
  • Data Type: 
    Proteomic/Metabolomic
    Disease: 
    ADRD
    Last Release Date: February 4, 2022
    Subjects: 423
    Files: 13
    Total size: 13MB
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    The identification of genetic risk factors for Alzheimer’s Disease (AD) provides additional to support that multiple pathways contribute to its onset and progression. However, the metabolomic and lipidomic profiles altered among carriers of distinct genetic risk factors is not fully understood. The...
  • Data Type: 
    Single Cell RNA Sequencing
    Disease: 
    AD
    Platform: 
    10X Genomics Single Cell Gene Expression v3.1
    Last Release Date: November 23, 2021
    Subjects: 44
    Files: 14
    Total size: 1TB
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    Alzheimer’s disease (AD) is the most prevalent cause of dementia. While there is no effective treatment for AD, a growing body of evidence points to passive immunotherapy with monoclonal antibodies against amyloid beta (Aβ) as a promising therapeutic strategy. Meningeal lymphatic drainage...
  • Data Type: 
    Genotyping SNP Array
    Imputation: 
    1000G Phase3v5TOPMed r2
    Platform: 
    Illumina Infinium Global Screening Array-24 Kit
    Last Release Date: September 16, 2021
    Subjects: 993
    Files: 57
    Total size: 182GB
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    In 2018, 960 respondents from LASI-DAD who consented to the blood sample collection have been genotyped using Illumina Infinium genotyping platforms. The datasets being submitted include the original genotype assayed by the genotyping platforms, imputed data to the 1000G reference panel, as...
  • Data Type: 
    Genotyping SNP ArraySingle Cell RNA Sequencing
    Disease: 
    Neuropsychiatric Brain Disorders
    Platform: 
    Illumina HiSeq 2500Illumina Infinium Global Screening Array-24 Kit
    Last Release Date: July 1, 2021
    Subjects: 108
    Files: 323
    Total size: 1TB
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    Human post-mortem brain samples were obtained from the Netherlands Brain Bank (NBB) and the Neuropathology Brain Bank and Research CoRE at Mount Sinai Hospital. The permission to collect human brain material was obtained from the Ethical Committee of the VU University Medical...
  • Data Type: 
    Genotyping SNP Array
    Disease: 
    AD
    Platform: 
    Illumina Infinium Global Screening Array-24 Kit
    Last Release Date: February 4, 2022
    Subjects: 268
    Files: 9
    Total size: 73MB
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    The 90+ Study was initiated in 2003 to study the oldest-old, the fastest growing age group in the United States. The 90+ Study is one of the largest studies of the oldest-old in the world. More than 1,600 people have enrolled. Initial...
  • Data Type: 
    Proteomic/MetabolomicQTL Summary Statistics
    Disease: 
    AD
    Open and Controlled Access Data: 
    Controlled AccessOpen Access
    Platform: 
    Somalogic SomaScan
    Last Release Date: November 7, 2023
    Subjects: 1,157
    Files: 31
    Total size: 361GB
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    Understanding the tissue-specific genetic controls of protein levels is essential to uncover mechanisms of post-transcriptional gene regulation. We previously generated a genomic atlas of protein levels in three tissues relevant to neurological disorders (brain, cerebrospinal fluid and plasma) by profiling thousands of...
  • Data Type: 
    WESWGS
    Last Release Date: August 15, 2023
    Subjects: 62,479
    Files: 135,725
    Total size: 1347TB
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    This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common workflow called VCPA (Variant Calling Pipeline and data management tool), a functionally...