• Data Type: 
    Single-neuron WGS
    Disease: 
    AD
    Platform: 
    Illumina
    Last Release Date: May 12, 2022
    Samples: 29
    Files: 353
    Total size: 62TB
    Single-neuron amplified genome libraries were sequenced (WGS) on Illumina instruments and aligned to the human reference genome GRCh37. Linked-read analysis (LiRA) and SCAN-SNV were used to identify single-cell somatic mutations. The single-cell dataset includes a total of 319 single-neuron genome sequences (172...
  • Data Type: 
    WESWGS
    Last Release Date: March 24, 2022
    Samples: 44,222
    Files: 85,698
    Total size: 619TB
    This dataset includes sequencing data from samples sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common workflow called VCPA (Variant Calling Pipeline and data management tool), a functionally equivalent CCDG/TOPMed pipeline....
  • Data Type: 
    GWAS
    Platform: 
    GSA
    Last Release Date: February 4, 2022
    Samples: 268
    Files: 9
    Total size: 73MB
    The 90+ Study was initiated in 2003 to study the oldest-old, the fastest growing age group in the United States. The 90+ Study is one of the largest studies of the oldest-old in the world. More than 1,600 people have enrolled. Initial...
  • Data Type: 
    Proteomic/Metabolomic
    Disease: 
    AD
    Last Release Date: February 4, 2022
    Samples: 423
    Files: 13
    Total size: 13MB
    The identification of genetic risk factors for Alzheimer’s Disease (AD) provides additional to support that multiple pathways contribute to its onset and progression. However, the metabolomic and lipidomic profiles altered among carriers of distinct genetic risk factors is not fully understood. The...
  • Data Type: 
    Methylation
    Disease: 
    AD
    Last Release Date: February 4, 2022
    Samples: 413
    Files: 7
    Total size: 6GB
    Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder with many biological processes, and molecular changes. The etiology of AD is complex and not specific to a single genetic factor. Epigenetic changes could help explain the missing heritability not capture in GWAS chips...
  • Data Type: 
    GWAS
    Imputation: 
    1000GHRC
    Platform: 
    HumanOmni2.5
    Last Release Date: January 27, 2022
    Samples: 19,042
    Files: 6
    Total size: 763GB
    These data include a total of 18,916 subjects from the Health and Retirement Study genotyped on Illumina HumanOmni2.5-arrays.  Data files also include imputed data using the 1000 Genomes and the Haplotype Reference Consortium (HRC) reference panels. Respondents who consented to the saliva...
  • Data Type: 
    Single Cell RNA Sequencing
    Disease: 
    AD
    Platform: 
    10Xchemistry_v3
    Last Release Date: November 23, 2021
    Samples: 44
    Files: 14
    Total size: 1TB
    Alzheimer’s disease (AD) is the most prevalent cause of dementia. While there is no effective treatment for AD, a growing body of evidence points to passive immunotherapy with monoclonal antibodies against amyloid beta (Aβ) as a promising therapeutic strategy. Meningeal lymphatic drainage...
  • Data Type: 
    GWAS
    Imputation: 
    1000GTOPMed
    Platform: 
    GSA
    Last Release Date: September 16, 2021
    Samples: 993
    Files: 57
    Total size: 182GB
    In 2018, 960 respondents from LASI-DAD who consented to the blood sample collection have been genotyped using Illumina Infinium genotyping platforms. The datasets being submitted include the original genotype assayed by the genotyping platforms, imputed data to the 1000G reference panel, as...
  • Data Type: 
    GWASSingle Cell RNA Sequencing
    Platform: 
    GSAHi-Seq
    Last Release Date: July 1, 2021
    Samples: 108
    Files: 323
    Total size: 1TB
    Human post-mortem brain samples were obtained from the Netherlands Brain Bank (NBB) and the Neuropathology Brain Bank and Research CoRE at Mount Sinai Hospital. The permission to collect human brain material was obtained from the Ethical Committee of the VU University Medical...