- Data Type:Risk ScoresDisease:ADOpen and Controlled Access Data:Controlled AccessLast Release Date: August 22, 2023Files: 18Total size: 19KBTo better capture the polygenic architecture of Alzheimer’s Disease (AD), we developed a joint genetic score, MetaGRS. We incorporated genetic variants for AD and 24 other traits from two independent cohorts, NACC (n = 3,174, training set) and UPitt (n = 2,053,...
- Data Type:Genotyping SNP ArrayImputation:TOPMed r2Open and Controlled Access Data:Controlled AccessPlatform:Illumina Infinium Global Screening Array-24 KitLast Release Date: June 1, 2023Subjects: 4,006Files: 8Total size: 343GBA dried blood spot (DBS) collection in Round 7 (2017) of NHATS provided the biological material for genotyping. Samples were genotyped at Erasmus Medical Center in Rotterdam, Netherlands on the Illumina Infinium Global Screening Array v3.0. The array contains clinical and rare...
- Data Type:Summary StatisticsDisease:ADLast Release Date: May 4, 2023Files: 3Total size: 1KBResveratrol exhibits a wide range of biological properties, including anti-glycation, antioxidant, anti-inflammation, neuroprotective (including against advanced dementia and Alzheimer’s disease), anti-cancer, and anti-aging activity in experimental models. Unfortunately, this compound exhibits low bioavailability and solubility, requiring large doses that can cause nausea...
- Data Type:Targeted GenotypingPlatform:TaqManThermo Hybaid MBS 0.2SLast Release Date: April 7, 2023Subjects: 19,193Files: 2Total size: 1MBThe APOE and Serotonin Transporter Alleles data product includes data for the APOE isoform, directly genotyped using a TaqMan allelic discrimination SNP assay, where available, or imputed from preexisting genotype array data otherwise. This file also includes human serotonin transporter (5HTTLPR) short...
- Data Type:QTL Summary StatisticsDisease:ADRDOpen and Controlled Access Data:Controlled AccessOpen AccessPlatform:Metabolon HD4Last Release Date: August 10, 2023Files: 1,414Total size: 749GBThe majority of metabolite quantitative trait loci (MQTL) were discovered using blood and urine tissues. This data represents the first large-scaled CSF and brain study, which will advance the understanding of genetic regulation in metabolite levels by identifying novel MQTLs. For 440...
- Data Type:QTL Summary StatisticsDisease:ADRDOpen and Controlled Access Data:Controlled AccessOpen AccessPlatform:Somalogic SomaScanLast Release Date: July 27, 2023Files: 7,034Total size: 2TBQuantitative trait locus (QTL) analysis has proven successful in the identification of causal genes at disease loci, but many of these loci still do not clearly link to genes. These QTL studies are either highly specific to plasma (for proteomics) or are...
- Data Type:WESDisease:ADPlatform:Illumina NovaSeq 6000Last Release Date: March 8, 2023Subjects: 170Files: 354Total size: 930GBThis ADSP release, containing 170 whole-exomes includes 1) sequencing read alignments in CRAM (compressed BAM) format for the newly sequenced 170 samples, (2) genomic Variant Call Format (gVCF) files generated by GATK4.1.1 on samples. The pVCF released here is provided as a...
- Data Type:Proteomic/MetabolomicDisease:COVID-19Platform:Somalogic SomaScanLast Release Date: January 18, 2023Subjects: 482Files: 8Total size: 36MBThe goal of WU350 cohort is to address the many complexities of the COVID-19 pandemic. Among the 332 COVID-19 cases, ~90% were symptomatic patients, 93.7% were hospitalized, 46.7% with ICU admission, 24.7% on ventilation, and 19.0% died due to COVID-19 (82 ventilated...
- Data Type:Genotyping SNP ArrayDisease:ADLast Release Date: December 13, 2022Subjects: 4,496Files: 8Total size: 2GBThe search for novel risk factors for Alzheimer disease relies on access to accurate and deeply phenotyped datasets. The Memory and Aging Project at the Knight-ADRC (Knight ADRC-MAP) collects plasma, CSF, fibroblast, neuroimaging clinical and cognition data longitudinally and autopsied brain samples....
- Data Type:Summary StatisticsWESWGSDisease:ADOpen and Controlled Access Data:Controlled AccessOpen AccessLast Release Date: December 13, 2022Files: 12Total size: 5GBWe performed Whole-exome and Whole-Genome association analyses with Alzheimer’s disease risk in ADSP data (NG00067.v5), focusing on non-Hispanic white individuals of European ancestry. Specifically, we designed novel variant filters that account for variant frequency differences across sequencing centers/platforms in the ADSP data....
- Data Type:Single-neuron WGSDisease:ADPlatform:IlluminaLast Release Date: May 12, 2022Subjects: 29Files: 353Total size: 62TBSingle-neuron amplified genome libraries were sequenced (WGS) on Illumina instruments and aligned to the human reference genome GRCh37. Linked-read analysis (LiRA) and SCAN-SNV were used to identify single-cell somatic mutations. The single-cell dataset includes a total of 319 single-neuron genome sequences (172...
- Data Type:Genotyping SNP ArrayImputation:1000G Phase3v5HRCPlatform:Illumina HumanOmni2.5-QuadLast Release Date: January 27, 2022Subjects: 19,042Files: 6Total size: 763GBThese data include a total of 18,916 subjects from the Health and Retirement Study genotyped on Illumina HumanOmni2.5-arrays. Data files also include imputed data using the 1000 Genomes and the Haplotype Reference Consortium (HRC) reference panels. Respondents who consented to the saliva...
- Data Type:QTL Summary StatisticsWGSDisease:ADPSPPlatform:Illumina HiSeq XLast Release Date: April 24, 2023Subjects: 1,369Files: 29Total size: 2GBStructural variants (SVs) were discovered in 1,760 donors by running a combination of seven different tools to capture the main classes of variation, including deletions (DEL), duplications (DUP), insertions (INS), inversions (INV), mobile element insertions (MEI), and complex rearrangements (CPX). We mapped...
- Data Type:Genotyping SNP ArrayDisease:ADPlatform:Illumina Infinium Global Screening Array-24 KitLast Release Date: November 22, 2022Subjects: 698Files: 9Total size: 146MBThe NCRAD Families sample set was genotyped at the Children’s Hospital of Philadelphia using the Illumina Infinium GSAMD-24v2-0_20024620_A1 BeadChip which captures genotype data on 759,993 genomic SNPs. These families are not evaluated in person. Family history and demographic data are collected and...
- Data Type:MethylationDisease:ADRDLast Release Date: February 4, 2022Subjects: 413Files: 7Total size: 6GBAlzheimer’s disease (AD) is a multifactorial neurodegenerative disorder with many biological processes, and molecular changes. The etiology of AD is complex and not specific to a single genetic factor. Epigenetic changes could help explain the missing heritability not capture in GWAS chips...
- Data Type:Proteomic/MetabolomicDisease:ADRDLast Release Date: February 4, 2022Subjects: 423Files: 13Total size: 13MBThe identification of genetic risk factors for Alzheimer’s Disease (AD) provides additional to support that multiple pathways contribute to its onset and progression. However, the metabolomic and lipidomic profiles altered among carriers of distinct genetic risk factors is not fully understood. The...
- Data Type:Single Cell RNA SequencingDisease:ADPlatform:10X Genomics Single Cell Gene Expression v3.1Last Release Date: November 23, 2021Subjects: 44Files: 14Total size: 1TBAlzheimer’s disease (AD) is the most prevalent cause of dementia. While there is no effective treatment for AD, a growing body of evidence points to passive immunotherapy with monoclonal antibodies against amyloid beta (Aβ) as a promising therapeutic strategy. Meningeal lymphatic drainage...
- Data Type:Genotyping SNP ArrayImputation:1000G Phase3v5TOPMed r2Platform:Illumina Infinium Global Screening Array-24 KitLast Release Date: September 16, 2021Subjects: 993Files: 57Total size: 182GBIn 2018, 960 respondents from LASI-DAD who consented to the blood sample collection have been genotyped using Illumina Infinium genotyping platforms. The datasets being submitted include the original genotype assayed by the genotyping platforms, imputed data to the 1000G reference panel, as...
- Data Type:Genotyping SNP ArraySingle Cell RNA SequencingDisease:Neuropsychiatric Brain DisordersPlatform:Illumina HiSeq 2500Illumina Infinium Global Screening Array-24 KitLast Release Date: July 1, 2021Subjects: 108Files: 323Total size: 1TBHuman post-mortem brain samples were obtained from the Netherlands Brain Bank (NBB) and the Neuropathology Brain Bank and Research CoRE at Mount Sinai Hospital. The permission to collect human brain material was obtained from the Ethical Committee of the VU University Medical...
- Data Type:Genotyping SNP ArrayDisease:ADPlatform:Illumina Infinium Global Screening Array-24 KitLast Release Date: February 4, 2022Subjects: 268Files: 9Total size: 73MBThe 90+ Study was initiated in 2003 to study the oldest-old, the fastest growing age group in the United States. The 90+ Study is one of the largest studies of the oldest-old in the world. More than 1,600 people have enrolled. Initial...
- Data Type:WESWGSLast Release Date: August 15, 2023Subjects: 62,479Files: 135,725Total size: 1347TBThis dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common workflow called VCPA (Variant Calling Pipeline and data management tool), a functionally...