- Data Type:WESWGSLast Release Date: March 24, 2022Samples: 44,222Files: 85,698Total size: 619TBThis dataset includes sequencing data from samples sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common workflow called VCPA (Variant Calling Pipeline and data management tool), a functionally equivalent CCDG/TOPMed pipeline....
- Last Release Date: February 4, 2022Samples: 268Files: 9Total size: 73MBThe 90+ Study was initiated in 2003 to study the oldest-old, the fastest growing age group in the United States. The 90+ Study is one of the largest studies of the oldest-old in the world. More than 1,600 people have enrolled. Initial...
- Last Release Date: February 4, 2022Samples: 423Files: 13Total size: 13MBThe identification of genetic risk factors for Alzheimer’s Disease (AD) provides additional to support that multiple pathways contribute to its onset and progression. However, the metabolomic and lipidomic profiles altered among carriers of distinct genetic risk factors is not fully understood. The...
- Last Release Date: February 4, 2022Samples: 413Files: 7Total size: 6GBAlzheimer’s disease (AD) is a multifactorial neurodegenerative disorder with many biological processes, and molecular changes. The etiology of AD is complex and not specific to a single genetic factor. Epigenetic changes could help explain the missing heritability not capture in GWAS chips...
- Last Release Date: January 27, 2022Samples: 19,042Files: 6Total size: 763GBThese data include a total of 18,916 subjects from the Health and Retirement Study genotyped on Illumina HumanOmni2.5-arrays. Data files also include imputed data using the 1000 Genomes and the Haplotype Reference Consortium (HRC) reference panels. Respondents who consented to the saliva...
- Data Type:Single Cell RNA SequencingDisease:ADPlatform:10Xchemistry_v3Last Release Date: November 23, 2021Samples: 44Files: 14Total size: 1TBAlzheimer’s disease (AD) is the most prevalent cause of dementia. While there is no effective treatment for AD, a growing body of evidence points to passive immunotherapy with monoclonal antibodies against amyloid beta (Aβ) as a promising therapeutic strategy. Meningeal lymphatic drainage...
- Data Type:GWASImputation:1000GTOPMedPlatform:GSALast Release Date: September 16, 2021Samples: 993Files: 57Total size: 182GBIn 2018, 960 respondents from LASI-DAD who consented to the blood sample collection have been genotyped using Illumina Infinium genotyping platforms. The datasets being submitted include the original genotype assayed by the genotyping platforms, imputed data to the 1000G reference panel, as...
- Data Type:GWASSingle Cell RNA SequencingPlatform:GSAHi-SeqLast Release Date: July 1, 2021Samples: 108Files: 323Total size: 1TBHuman post-mortem brain samples were obtained from the Netherlands Brain Bank (NBB) and the Neuropathology Brain Bank and Research CoRE at Mount Sinai Hospital. The permission to collect human brain material was obtained from the Ethical Committee of the VU University Medical...