• In 2018, 960 respondents from LASI-DAD who consented to the blood sample collection have been genotyped using Illumina Infinium genotyping platforms. The datasets being submitted include the original genotype assayed by the genotyping platforms, imputed data to the 1000G reference panel, as well as imputed data to the TOPMed reference...
    Data Type: 
    Samples: 993
    Files: 57
    Total size (MB): 64
  • Human post-mortem brain samples were obtained from the Netherlands Brain Bank (NBB) and the Neuropathology Brain Bank and Research CoRE at Mount Sinai Hospital. The permission to collect human brain material was obtained from the Ethical Committee of the VU University Medical Center, Amsterdam, The Netherlands, and the Mount Sinai...
    Data Type: 
    GWASSingle Cell RNA Sequencing
    Last Release Date: July 1, 2021
    Samples: 108
    Files: 323
    Total size (TB): 1
  • Alzheimer’s disease (AD) is the most prevalent cause of dementia. While there is no effective treatment for AD, a growing body of evidence points to passive immunotherapy with monoclonal antibodies against amyloid beta (Aβ) as a promising therapeutic strategy. Meningeal lymphatic drainage plays an important role in Aβ accumulation in...
    Data Type: 
    Single Cell RNA Sequencing
    Last Release Date: June 1, 2021
    Samples: 44
    Files: 6
    Total size (KB): 526
  • This dataset includes sequencing data from samples sequenced by the Alzhiemer’s Disease Sequencing Project and other AD and Related Dementia’s studies. Samples are processed using a common workflow called VCPA (Variant Calling Pipeline and data management tool), a functionally equivalent CCDG/TOPMed pipeline. Data Releases: The first release (July 30, 2018)...
    Data Type: 
    Last Release Date: July 6, 2021
    Samples: 44,223
    Files: 84,652
    Total size (TB): 568