Data Summary

Funded in 2012, NIAGADS became the NIA-designated national data repository to facilitate data sharing for the study of genetics of Alzheimer’s disease and other related dementias (ADRD). The NIAGADS Data Sharing Service (DSS) was developed in 2018 to host and share data generated from the Alzheimer’s Disease Sequencing Project (ADSP) with the research community. See below for information about data hosted in each database (last updated February 2020).

300+ approved Data Access Requests

via DSS

Number of approved DARs for ADSP data through the DSS NIAGADS data portal. Go to DARs page to see the full list of approved requests.

179

via dbGaP

NIAGADS manages the submission and review of applications for the ADSP dataset in dbGaP (phs000572). See all approved requests.

via NIAGADS

Number of approved DARs through the main NIAGADS database. Go to niagads.org to see the datasets available for access.

NIAGADS DSS Data Summary

Data Numbers

The ADSP has released whole-genomes for 16,780 subjects which include CRAMs, gVCFs, a quality-controlled project level VCF, and phenotypes as well as whole exomes for 20,287 subjects including CRAMs, gVCFs, and phenotypes. These data are available for qualified researchers to access. More information can be found on the ADSP Umbrella dataset page.

35,095

subjects

86,036

files

620.01 TB

total size

Sample Composition

NIAGADS DSS is currently hosting 16,906 whole genomes and 20,503 whole exomes from the ADSP and other AD and Related Dementia’s studies. A breakdown by affection status and Ethnicity is shown here.

NIAGADS Data Summary

Datasets

90,644

Samples

Data Types

Data Availability and Types

All data derived from NIA funded Alzheimer’s Disease (AD) genetic studies are expected to be deposited in NIAGADS or another NIA approved site. As the NIA designated repository, NIAGADS has assisted with the deposition of genomic data of various types. Go to NIAGADS to view available datasets.