Data Summary
Funded in 2012, NIAGADS became the NIA-designated national data repository to facilitate data sharing for the study of genetics of Alzheimer’s disease and other related dementias (ADRD). The NIAGADS Data Sharing Service (DSS) was developed in 2018 to host and share data generated from the Alzheimer’s Disease Sequencing Project (ADSP) with the research community. See below for information about data hosted in each database (last updated February 2020).
240+ approved Data Access Requests
61
via DSS
Number of approved DARs for ADSP data through the DSS NIAGADS data portal. Go to DARs page to see the full list of approved requests.
165
via dbGaP
NIAGADS manages the submission and review of applications for the ADSP dataset in dbGaP (phs000572). See all approved requests.
53
via NIAGADS
Number of approved DARs through the main NIAGADS database. Go to niagads.org to see the datasets available for access.
NIAGADS DSS Data Summary
Data Numbers
The ADSP has released whole-genomes for 4,750 subjects which include CRAMs, gVCFs, a quality-controlled project level VCF, and phenotypes as well as whole exomes for 19,705 subjects including CRAMs, gVCFs, and phenotypes. These data are available for qualified researchers to access. More information can be found on the ADSP Umbrella dataset page.
23,868
subjects
50,868
files
195.8 TB
total size
Sample Composition
NIAGADS DSS is currently hosting 4,789 whole genomes and 19,922 whole exomes from the ADSP and other AD and Related Dementia’s studies. A breakdown by affection status and Ethnicity is shown here.
Future Datasets
17K whole-genomes
GCAD is currently processing an additional 13,000 whole-genomes to be joint-called with the first whole-genome dataset, totaling about 17,000 whole-genomes. Joint calling of this dataset will begin in March 2020.
NIAGADS Data Summary
64
Datasets
84,220
Samples
12
Data Types
Data Availability and Types
All data derived from NIA funded Alzheimer’s Disease (AD) genetic studies are expected to be deposited in NIAGADS or another NIA approved site. As the NIA designated repository, NIAGADS has assisted with the deposition of genomic data of various types. Go to NIAGADS to view available datasets.
