Data Summary

Funded in 2012, NIAGADS became the NIA-designated national data repository to facilitate data sharing for the study of genetics of Alzheimer’s disease and other related dementias (ADRD). The NIAGADS Data Sharing Service (DSS) was developed in 2018 to host and share data generated from the Alzheimer’s Disease Sequencing Project (ADSP) with the research community. See below for information about data hosted in each database (last updated February 2020).

240+ approved Data Access Requests

59
via DSS
165
via dbGaP
53
via NIAGADS

NIAGADS DSS Data Summary

Data Numbers

The ADSP has released whole-genomes for 4,750 subjects which include CRAMs, gVCFs, a quality-controlled project level VCF, and phenotypes as well as whole exomes for 19,705 subjects including CRAMs, gVCFs, and phenotypes. These data are available for qualified researchers to access. More information can be found on the ADSP Umbrella dataset page.
23,868
subjects
50,883
files
195.81 TB
total size

Sample Composition

NIAGADS DSS is currently hosting 4,789 whole genomes and 19,922 whole exomes from the ADSP and other AD and Related Dementia’s studies. A breakdown by affection status and Ethnicity is shown here.

Future Datasets

17K whole-genomes
GCAD is currently processing an additional 13,000 whole-genomes to be joint-called with the first whole-genome dataset, totaling about 17,000 whole-genomes. Joint calling of this dataset will begin in March 2020.

NIAGADS Data Summary

64
Datasets
 
84,220
Samples
 
12
Data Types

Data Availability and Types

All data derived from NIA funded Alzheimer’s Disease (AD) genetic studies are expected to be deposited in NIAGADS or another NIA approved site. As the NIA designated repository, NIAGADS has assisted with the deposition of genomic data of various types. Go to NIAGADS to view available datasets.
Graph updated July 2019