The p-value only files are available in the “Open Access Dataset” tab.
To access the full data, please log into DSS and submit an application.
Within the application, add this dataset (accession NG00179) in the “Choose a Dataset” section.
Once approved, you will be able to log in and access the data within the DARM portal.

Description

This dataset includes summary statistics from AD GWAS in 9,168 subjects of African ancestry (Ncases = 2,903, Ncontrols = 6,265).

Genome-wide single-variant association analyses of common and rare variants were performed individually on each dataset using SNPTEST. Logistic regression was used for case-control datasets and generalized estimating equations (GEE) as implemented in GWAF were used for family-based datasets. Associations with extreme beta coefficients (|β| > 5) were filtered out. Within-study results were subsequently meta-analyzed with METAL employing an inverse-variance based model with genomic control. Variants showing significant heterogeneity between studies (I2 > 75%) were removed.

There are summary statistics for two different models:
Model1: Age, sex, and population stratification (as determined by the first three principal components (PCs) calculated individually on each dataset) were entered as covariates.
Model2: Same covariates as Model 1, but APOEe4 allele dosage (coded as 0,1,2) was entered as an additional covariate.

Available Filesets

NameAccessionLatest ReleaseDescription
AD AA GWAS Ray: Full Summary Statistics (application needed)fsa000143NG00179.v1Full Summary Statistics
AD AA GWAS Ray: P-values only (open access)fsa000144NG00179.v1P-values only

View the File Manifest for a full list of files released in this dataset.