Overview
To access this data, please log into DSS and submit an application.
Within the application, add this dataset (accession NG00186) in the “Choose a Dataset” section.
Once approved, you will be able to log in and access the data within the DARM portal.
Description
The AABC (formerly HCP-A) is working to uncover how brain structure and function changes as a normal part of aging by collecting and analyzing multimodal neuroimaging, behavioral, and genetic data. The specific goal of this analyses is to identify genetic variants associated with healthy aging.
Genotyping for these participants were generated through Illumina GSA v3.0 genotyping array and imputed using the TOPMed Reference Panel. Samples were QC’d using PLINK and retained using standard pipelines, resulting in 1,024 samples and 164,824,889 total variants (10,147,726 passing a 1% MAF threshold with a 98% call rate).
No phenotypes are provided with this dataset. Request phenotype data, APOE, and Polygenic Risk Scores via BALSA: https://balsa.wustl.edu/project?project=AABC2. Instructions for getting access can be found at the bottom of this page: https://www.humanconnectome.org/study/hcp-lifespan-aging/data-releases.
Sample Summary per Data Type
| Sample Set | Accession | Data Type | Number of Samples |
|---|---|---|---|
| Genetic Component of the Mapping the Human Connectome During Typical Aging (HCP-A) & Vulnerability and Resiliency in the Aging Adult Brain Connectome (AABC) | snd10137 | Genotyping SNP Array | 1,024 |
Available Filesets
| Name | Accession | Latest Release | Description |
|---|---|---|---|
| AABC GWAS | fsa000162 | NG00186.v1 | TOPMed Imputation |
View the File Manifest for a full list of files released in this dataset.