The Cache County Study on Memory Health and Aging (CCS) was initiated in 1994 to investigate the association of APOE genotype and environmental exposures on cognitive function and dementia. This cohort of 5092 Cache County, Utah, residents (90% of those aged 65 years or older in 1994), has been followed continuously for over 15 years, with four triennial waves of data collection and additional clinical assessments for those at high-risk for dementia. DNA samples were obtained from 97.6% of participants. The Cache County population is exceptionally long-lived and ranked number one in life expectancy among all counties in the 1990 US Census. All but one of the members of the CCS have been linked to the UPDB and their extended genealogies are known. This population was the source of most of the Centre d’Etude du Polymorphisme Humain (CEPH) families that have been used to represent Caucasians in many genetic studies worldwide, including the HapMap project. Recent analyses confirm that these data are representative of the general European-American population. For this study, we needed both AD cases and resilient individuals identified in the same pedigrees.” (Ridge, P.G., Karch, C.M., Hsu, S. et al. Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience. Genome Med 9, 100 (2017).