The Peru Alzheimer’s Disease Initiative (PeADI) is being conducted at several sites in Peru including Lima (Marca-Ysabel et al. 2021). The Mestizo population living in Lima, the capital city, is comprised of ~76% of Amerindian, 11% Southern European, and 3% Northern African ancestries, and a smaller proportion of western central Africa, western central Europe, Finland, northern Siberia and Jewish diaspora. Cases will be clinic based and controls will be clinic and community based.

Participants were ascertained for an AD/ADRD Memory Study, including healthy controls. Eligibility was based on self-reported Peruvian heritage with mestizo and Quechua being the two most frequent self-descriptors. This cohort is an admixed Hispanic/Latino population with substantial Amerindian descent. Most participants were recruited in Lima and surrounding areas to the north (e.g., Huacho).

Participants were ascertained and evaluated through local memory clinics (Instituto Nacional de Ciencias Neurologicas – INCN) and community centers. Some participants were evaluated in their homes. All participants greater than 65 years of age underwent a screening and standard clinical evaluation consisting of a medical and family history interview, neuropsychological testing, behavioral and emotional assessments, and functional measures. Venous blood samples (or saliva samples when needed) were collected on all participants. All assessments were conducted in the preferred language of the participant or knowledgeable informant.