The Puerto Rican Alzheimer’s Disease Initiative (PRADI) is a NIH NIA study of late-onset Alzheimer disease focused on the Caribbean-Hispanic Puerto Rican population. Participants were ascertained for an AD/ADRD Memory Study, including healthy controls. Eligibility was based on self-reported Puerto Rican heritage. Most participants were recruited in the Island of Puerto Rico with a small fraction being ascertained in South Florida, New York, and Connecticut. 

Participants were ascertained and evaluated through community centers, private memory clinics and adult day care centers. Some participants were evaluated in their homes. All participants greater than 60 years of age underwent a standard clinical evaluation consisting of a medical and family history interview, neuropsychological testing, behavioral and emotional assessments, and functional measures. Venous blood samples (or saliva samples when needed) were collected on all participants. All assessments were conducted in the preferred language of the participant or knowledgeable informant.