The Wisconsin Registry for Alzheimer’s Prevention (WRAP) is an ongoing longitudinal observational cohort study of individuals age 40-65 at baseline who do not have dementia. Since 2001, WRAP has enrolled more than 1,700 individuals, 73% of whom had a parental history of probable Alzheimer’s disease (AD) dementia. Participants return for a second visit approximately 4 years after baseline, and subsequent visits occur every 2 years. At each visit, a cognitive test battery is administered, self-reported medical and lifestyle histories (e.g., diet, physical and cognitive activity, sleep, and mood) are assessed via questionnaire, and blood is drawn for laboratory tests, metabolomics, and genomics. A subset of participants have also undergone molecular imaging, structural imaging, and cerebrospinal fluid collection for biomarker measurement.

GeneRations Of WRAP (GROW) is an ancillary study to the Wisconsin Registry for Alzheimer’s Prevention (WRAP), a longitudinal cohort study enriched for individuals with a parental history of probable Alzheimer’s disease (AD) dementia. GROW is a family study that recruited extended family members of existing WRAP participants. Genomic data from family members with probable AD dementia were collected via banked brains or saliva. Individuals free of dementia and within the WRAP eligibility age of 40-65 were enrolled in WRAP. At each study visit, a cognitive test battery is administered, self-reported medical and lifestyle histories (e.g., diet, physical and cognitive activity, sleep, and mood) are assessed via questionnaire, and blood is drawn for laboratory tests, metabolomics, and genomics. A subset of participants have also undergone molecular imaging, structural imaging, and cerebrospinal fluid collection for biomarker measurement.