ADSP Data Processing
- PI
- Wang, Li-San
- DAR ID
- 10000
- Initial Approval Date
- August 23, 2018
- Current DAR Status
- Active
- PI Institution
- University of Pennsylvania
- PI Institution Country
- United States
- PI Institution Type
- Non-Profit
Requested Datasets (1)
Research Use Statement
NIAGADS is the data coordinating center for ADSP. This request will allow us to access genotype and phenotype data for all ADSP samples and perform data processing and quality assurance, before distributing to the scientific community.
Currently a data deposition plan is being developed by ADSP:
1. Plans for aggregating phenotype, GWAS, and exome chip genotype data are in place, and NIAGADS will work with data contributors to organize and review files before data are distributed to study investigators.
2. As suggested by dbGaP, NIAGADS will work with dbGaP/SRA and the three NHGRI large-scale sequencing centers to develop a plan for reviewing incoming sequencing data. This will be done in parallel with basic quality assurance procedures by dbGaP/SRA before data are promoted to archival status and ready for analysis.
NIA is in discussion with other similar whole-genome and whole-exome sequencing projects. We plan to harmonize these additional datasets with the ADSP WGS/WES data so the community can combine these datasets for analysis. All associated phenotypes are minimized and there is minimal risk to the participants.
Currently a data deposition plan is being developed by ADSP:
1. Plans for aggregating phenotype, GWAS, and exome chip genotype data are in place, and NIAGADS will work with data contributors to organize and review files before data are distributed to study investigators.
2. As suggested by dbGaP, NIAGADS will work with dbGaP/SRA and the three NHGRI large-scale sequencing centers to develop a plan for reviewing incoming sequencing data. This will be done in parallel with basic quality assurance procedures by dbGaP/SRA before data are promoted to archival status and ready for analysis.
NIA is in discussion with other similar whole-genome and whole-exome sequencing projects. We plan to harmonize these additional datasets with the ADSP WGS/WES data so the community can combine these datasets for analysis. All associated phenotypes are minimized and there is minimal risk to the participants.
Non-Technical Summary
NIAGADS is the data coordinating center for ADSP. This request will allow us to access genotype and phenotype data for all ADSP samples and perform data processing and quality assurance, before distributing to the scientific community.
Reported Publications (5)
Publications shown are those reported by investigators through NIAGADS DAR reporting and renewal processes and may not represent a complete list of publications associated with the project.
- Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells. Wang H, et al. Movement disorders : official journal of the Movement Disorder Society. 2025. PMID: 40055946
- Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project. Lee WP, et al. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024. PMID: 39428839
- Human whole-exome genotype data for Alzheimer's disease. Leung YY, et al. Nature communications. 2024. PMID: 38263370
- NIAGADS Alzheimer's GenomicsDB: A resource for exploring Alzheimer's disease genetic and genomic knowledge. Greenfest-Allen E, et al. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024. PMID: 37881831
- VCPA: genomic variant calling pipeline and data management tool for Alzheimer's Disease Sequencing Project. Leung YY, et al. Bioinformatics (Oxford, England). 2019. PMID: 30351394